CBR-5884
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- CAS-Nr.
- 681159-27-3
- Englisch Name:
- CBR-5884
- Synonyma:
- CBR-5884;CBR 5884;CBR5884;CBR-5884, 10 mM in DMSO;CBR 5884,inhibit,CBR-5884,Inhibitor,CBR5884;ethyl 4-(cyanosulfanyl)-5-(furan-2-amido)-3-methylthiophene-2-carboxylate;Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate;Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate;2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester
- CBNumber:
- CB93128968
- Summenformel:
- C14H12N2O4S2
- Molgewicht:
- 336.39
- MOL-Datei:
- 681159-27-3.mol
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CBR-5884 Eigenschaften
- Siedepunkt:
- 378.1±42.0 °C(Predicted)
- Dichte
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO (up to 50 mg/ml) or in DMF (up to 50 mg/ml).
- pka
- 11.25±0.70(Predicted)
- Aggregatzustand
- paste
- Farbe
- white to beige
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months.
- InChI
- 1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17)
- InChIKey
- QBVIRPJBDIZKBC-UHFFFAOYSA-N
- SMILES
- CC1=C(C(OCC)=O)SC(NC(C2=CC=CO2)=O)=C1SC#N
CBR-5884 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.
Biochem/physiol Actions
CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) that inhibits proliferation of melanoma and breast cancer lines. CBR-5884 inhibits de novo serine synthesis in in cancer cells.
CBR-5884 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CBR-5884 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 93)Lieferanten
681159-27-3()Verwandte Suche:
- CBR-5884
- Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
- CBR 5884;CBR5884
- ethyl 4-(cyanosulfanyl)-5-(furan-2-amido)-3-methylthiophene-2-carboxylate
- 2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester
- CBR 5884,inhibit,CBR-5884,Inhibitor,CBR5884
- Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate
- CBR-5884, 10 mM in DMSO
- 681159-27-3
