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Meclozindihydrochlorid

Meclizine dihydrochloride Struktur
1104-22-9
CAS-Nr.
1104-22-9
Bezeichnung:
Meclozindihydrochlorid
Englisch Name:
Meclizine dihydrochloride
Synonyma:
Meclozine Hcl;diadril;bonamine;NSC 28728;Navidoxine;)-4-(3-methyL;Meclizine 2HCl;Meclizine diHCl;Meclozine ,Bonamine;ancolandihydrochloride
CBNumber:
CB9362486
Summenformel:
C25H29Cl3N2
Molgewicht:
463.87
MOL-Datei:
1104-22-9.mol

Meclozindihydrochlorid Eigenschaften

Schmelzpunkt:
210.0 to 214.0 °C
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble5mg/mL, clear (warmed)
Aggregatzustand
powder
Farbe
white to beige
InChI
1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H
InChIKey
VCTHNOIYJIXQLV-UHFFFAOYSA-N
SMILES
[Cl-].[Cl-].Clc1ccc(cc1)C(N3CCN(CC3)Cc4cc(ccc4)C)c2ccccc2.[H+].[H+]
CAS Datenbank
1104-22-9(CAS DataBase Reference)
EPA chemische Informationen
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-63
S-S?tze: 22-36
WGK Germany  3
RTECS-Nr. TL2005000
TSCA  TSCA listed
HS Code  2933.59.8000
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Repr. 2
Toxizit?t LD50 oral in mouse: 1600mg/kg
Bildanzeige (GHS) Exclamation Mark (GHS07)Health Hazard (GHS08)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Meclozindihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.

Chemische Eigenschaften

White or yellowish-white, slightly hygroscopic, crystalline powder.

Verwenden

Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.

Sicherheitsprofil

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.

Solubility in organics

Meclizine dihydrochloride is readily soluble in chloroform and pyridine, slightly soluble in dilute acids and ethanol, and insoluble in water or ether.

Meclozindihydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Meclozindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 308)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29640 60
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 742 58
Shanghai Longyu Biotechnology Co., Ltd.

info@longyupharma.com China 2421 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29792 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
+8613580539051
joe@yuhengpharm.com CHINA 21142 58
SIMAGCHEM CORP
+86-5922680277 +86-13806087780
sale@simagchem.com China 17346 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30225 58

1104-22-9(Meclozindihydrochlorid)Verwandte Suche:


  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride
  • 1-((4-Chlorophenyl)(phenyl)Methyl)-4-(3-Methylbenzyl)piperazine dihydrochloride
  • Meclizine 2HCl
  • Piperazine,1-[(4-chlorophenyl)phenylMethyl]-4-[(3-Methylphenyl)Methyl]-, hydrochloride(1:2)
  • 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazine,hydrochloride (1:2)
  • 1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-piperazine dihydrochloride
  • 1-p-chlorbenzhydryl-m-methylbenzylpiperazinedihydrochloride
  • ancolandihydrochloride
  • bonamine
  • diadril
  • MECLIZINE DIHYDROCHLORIDE
  • 1-([4-CHLOROPHENYL]PHENYLMETHYL)-4-([3-METHYLPHENYL]-METHYL)PIPERAZINE DIHYDROCHLORIDE
  • 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-piperazindih
  • 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-piperazindihydrochlorid
  • 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazindihyd
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (9CI)
  • Postafene dihydrochloride
  • Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride
  • meclozinedihydrochloride
  • parachloraminedihydrochloride
  • Meclozine dihydrochloride monohydrate
  • Meclizine diHCl
  • 1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride
  • mecilizine hydrochloride
  • Navidoxine
  • NSC 28728
  • Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride (6CI, 8CI)
  • 1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)p
  • Meclozine ,Bonamine
  • MeclizineDihydrochloride>
  • Meclozine dihydrochloride CRS
  • )piperazine dihydrochL
  • )-4-(3-methyL
  • 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine Dihydrochloride
  • Meclizine dihydrochloride USP/EP/BP
  • Meclizine dihydrochloride, 10 mM in DMSO
  • MECLIZINE HYDROCHLORIDE USP
  • Meclozine Hcl
  • 1104-22-9
  • C25H27Cl2N22HCl
  • C25H27ClN22ClH
  • C25H29Cl3N2
  • C25H27ClN22HCl
  • PROVOCHOLINE
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