5'-DEOXY-5'-METHYLTHIOADENOSINE
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- CAS-Nr.
- 2457-80-9
- Englisch Name:
- 5'-DEOXY-5'-METHYLTHIOADENOSINE
- Synonyma:
- MTA;Methylthioadenosine;5'-S-Methyl-5'-thioadenosine;5'-Methylthioadenosine;Adenylthiomethylpentose;(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol;MESADO;5’-methylthioadenosine;Adenosyl Methionine Impurity 1;beta-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-
- CBNumber:
- CB9392566
- Summenformel:
- C11H15N5O3S
- Molgewicht:
- 297.33
- MOL-Datei:
- 2457-80-9.mol
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5'-DEOXY-5'-METHYLTHIOADENOSINE Eigenschaften
- Schmelzpunkt:
- 210-213 °C (dec.)
- Siedepunkt:
- 642.7±65.0 °C(Predicted)
- Dichte
- 1.85±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMF (Sparingly), DMSO (Slightly), Methanol (Slightly)
- pka
- 13.10±0.70(Predicted)
- Aggregatzustand
- White solid
- Farbe
- White to Off-White
- Biologische Quelle
- synthetic (organic)
- BRN
- 42420
- Kosmetik-Inhaltsstoffe Funktionen
- SKIN CONDITIONING
- InChI
- InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
- InChIKey
- WUUGFSXJNOTRMR-IOSLPCCCSA-N
- SMILES
- S(C)C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
22-24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
AU7410000 |
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| F |
10-21 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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5'-DEOXY-5'-METHYLTHIOADENOSINE Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
5′-Deoxy-5′-(methylthio)adenosine has been used as a protein methylation inhibitor to reduce E2F transcription factor 1 (E2F1) protein abundance in hepatocellular carcinoma (HCC) cells. It has also been used to inhibit histone methylation modification and study its role in hypoxia inducible factor-1 (Hif-1) nuclear transport.
Definition
ChEBI: Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group.
l?uterung methode
Recrystallise it from H2O and sublime it at 200o/0.004mm. [v.Euler & Myrb.ck Hoppe Seyler's Z physiol Chem 177 237 1928, Weygand & Trauth Chem Ber 84 633 1951, Baddiley et al. J Chem Soc 2662 1953.] The hydrochloride has m 161-162o [Kuhn & Henkel Hoppe Seyler's Z Physiol Chem 269 41 1941]. The picrate has m 183o(dec) (from H2O). [Beilstein 26 III/IV 3675.]
5'-DEOXY-5'-METHYLTHIOADENOSINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5'-DEOXY-5'-METHYLTHIOADENOSINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 183)Lieferanten
2457-80-9()Verwandte Suche:
- 2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol
- 7-(5-Methylthio-5-deoxy-D-ribofuranosyl)-7H-purine-6-amine
- 7-[Tetrahydro-3α,4α-dihydroxy-5β-(methylthiomethyl)furan-2-yl]-7H-purin-6-amine
- 5'-S-Methyl-5'-thioadesine
- 5'-Deoxy-5'-(methylthio)adenosine ,98%
- 1-(6-AMino-9H-purin
- 5'-Deoxy(Methylthio)adenosine
- NSC 335422
- Adenosine, 5'-S-Methyl-5'-thio-
- 5'-Methylthioadenosine (VitaMin L2)
- 5'-(Methylthio)-5'-deoxyadenosine
- 5’-(methylthio)adenosine
- 5’-s-methyl-5’-thio-adenosin
- 5’-s-methylthioadenosine
- vitaminl(sub2)
- 5'-DEOXY-5'-METHYLTHIOADENOSINE
- 2,3-Dihydro-2-thioxo-9H-purin-6(1H)-one
- 5-Deoxy-5-methylthioadenosine - CAS 2457-80-9 - Calbiochem
- ′-S-Methyl-5′-thioadenosine
- Ademetionine 1,4-Butanedisulfonate Impurity 3
- Methylthioadenosine reference substance
- 5'-DEOXY-5'-METHYLTHIOADENOSINE USP/EP/BP
- SKL060
- beta-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-
- MESADO
- Adenylthiomethylpentose
- Adenosyl Methionine Impurity 1
- 13C5]-5'-deoxy-5'-methylthioadenosine
- 13C5]-5'-Deoxy-5'-methylthioadenosine([13C5]-MTA)
- Methioadenosine
- 5''-Deoxy-5''-methylthioadenosine (Methylthioadenosine), Adenosine A1 receptor agonist
- 5''-Methylthioadenosine
- 5'-Deoxy-5'-methylthioadenosine (Methylthioadenosine), Adenosine A1 receptor agonist
- 5'-Deoxy-5'-methylthioadenosine (Methylthioadenosine), Adenosine A1 receptor agonist
- (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol - [A71712]
- Methylthiamine
- (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol
- 5’-methylthioadenosine
- 5'-S-Methyl-5'-thioadenosine
- 5'-Methylthioadenosine
- Methylthioadenosine
- MTA
- 2457-80-9
- C11H15N5O3S
- C11H15N5O3S1
- Nucleoside Analogs
- Nucleosides, Nucleotides, Oligonucleotides
- Biochemicals and Reagents
- BioChemical
- Biochemicals and Reagents
- Nucleoside Analogs
- Nucleosides, Nucleotides, Oligonucleotides
