Loteprednol etabonate
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- CAS-Nr.
- 82034-46-6
- Englisch Name:
- Loteprednol etabonate
- Synonyma:
- Etabonate;Alrex;HGP 1;P 5604;Lotemax;CDDD 5604;On carboclofen;Etocloteprednol;Lotemax|||Alrex;LOTEPREDNOL ETABONATE
- CBNumber:
- CB9396463
- Summenformel:
- C24H31ClO7
- Molgewicht:
- 466.95
- MOL-Datei:
- 82034-46-6.mol
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Loteprednol etabonate Eigenschaften
- Schmelzpunkt:
- 220.5-223.5
- Siedepunkt:
- 600.1±55.0 °C(Predicted)
- Dichte
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble5mg/mL, clear (warmed)
- Aggregatzustand
- powder
- pka
- 14.06±0.70(Predicted)
- Farbe
- white to beige
- Wasserl?slichkeit
- <1mg/L(23 ºC)
- Stabilit?t:
- Hygroscopic
- InChIKey
- DMKSVUSAATWOCU-ICASLIHPSA-N
- SMILES
- O([C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@@]4([C@@]3([H])[C@H](C[C@]12C)O)C)=O)C(=O)OCCl)C(=O)OCC
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
2937.22.0000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Loteprednol etabonate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Loteprednol etabonate was introduced in the US as Lotemax
(opththalmic suspension at 0.5%) for the treatment of steroid-responsive
inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and
anterior segment of the ocular globe, and as Alrex (opththalmic suspension at
0.2%) for the symptomatic treatment of seasonal allergic conjunctivitis.
Loteprednol etabonate is a novel soft corticosteroid with a superior efficacy and
an improved safety profile compared to prior ophthalmic steroids due to its
metabolic lability and a fast enzymatic transformation to inactive metabolite. A
combination of Lotemax with the antibiotic Tobramycin is currently under
development.
Chemische Eigenschaften
Loteprednol etabonate is a micronized sterile white to off-white crystalline powder. It is practically insoluble in water and sparingly soluble in alcohol.
Verwenden
Loteprednol etabonate is an anti-inflammatory corticosteroid used in ophthalmology. It is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides.
Allgemeine Beschreibung
Loteprednol etabonate,chloromethyl 17α-[(ethoxycarbonyl)oxy]-11β-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (Alrex,Lotemax), has a modified carboxylate at the C17 positionrather than the typical ketone functionality. This modificationmaintains affinity for the GR but allows facile metabolismto inactive metabolites. This limits the systemic actionof the drug. Loteprednol etabonate is used as anophthalmic suspension that has greatly reduced systemicaction because of rapid metabolism to the inactive carboxylate.
Loteprednol etabonate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Loteprednol etabonate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 388)Lieferanten
82034-46-6()Verwandte Suche:
- LOTEPREDNOL ETABONATE
- Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11b,17a)-
- Lotemax
- 17α-(Ethoxycarbonyloxy)-11β-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid chloromethyl ester
- 17α-(Ethoxycarbonyloxy)-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid chloromethyl ester
- 3-Oxo-11β-hydroxy-17α-(ethoxycarbonyloxy)androsta-1,4-diene-17-carboxylic acid chloromethyl ester
- Lotoprednol etabonate
- CDDD-5604, HGP-1, P-5604, Alrex, Lotemax
- Androsta-1,4-diene-17-carboxylicacid,17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-,chloromethylester,
- chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-17-carboxylate
- (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-androsta-1,4-diene-17-carboxylic Acid ChloroMethyl Ester
- (11b,17a)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-Androsta-1,4-diene-17-carboxylic acid chloromethyl ester
- CDDD 5604
- HGP 1
- P 5604
- (11β,17α)-7-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-androsta-1,4-diene-17-carboxylic acid chloromethyl ester
- Loteprednol etabonate, >=99%
- Loteprednol etabonate WS
- 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester
- Loteprednol Impurity 10
- Loteprednol Etabonate| Etabonate
- Loteprednol etabonate,100ppm
- Loteprednol etabonate,HGP 1
- Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11β,17α)-
- Loteprednol etabonate Solution, 100μg/mL
- (8S,9S,10R,11S,13S,14S,17S)-Chloromethyl 17-((ethoxycarbonyl)oxy)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
- (11beta,17alpha)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid Chloromethyl Ester
- Chloromethyl (11beta,17alpha)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate
- Loteprednol Etabonate(Micronized)
- Loteprednol etabonate USP/EP/BP
- Loteprednol EtabonateQ: What is
Loteprednol Etabonate Q: What is the CAS Number of
Loteprednol Etabonate Q: What is the storage condition of
Loteprednol Etabonate
- Etocloteprednol
- (8S,9S,10R,11S,13S,14S,17R)-chloromethyl 17-((ethoxycarbonyl)oxy)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
- Lotemax|||Alrex
- Loteprednol etabonate, 10 mM in DMSO
- Loteprednol etabonate - Bio-X ?
- Loteprednol Impurity 40
- On carboclofen
- Loteprednol etabonate (Standard)
- Alrex
- Etabonate
- 82034-46-6
- 82304-46-6
- 36435-29-3
- C24H31ClO7
- C24H31O7CL
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- Alrex, Lotemax
- Hormone Drugs
- APIs
- Steroid and Hormone
- API
- 82034-46-6
