(R)-2-PHENYLPIPERIDINE
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- CAS-Nr.
- 58613-54-0
- Englisch Name:
- (R)-2-PHENYLPIPERIDINE
- Synonyma:
- (R)-2-PHENYLPIPERIDINE;(2R)-2-phenylpiperidine;(R)-(+)-6-phenylpiperidine;(R)-2-Phenylpiperidine 95%;Piperidine, 2-phenyl-, (2R)-;(R)-2-Phenylpiperidine;N-methyl-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide
- CBNumber:
- CB9407604
- Summenformel:
- C11H15N
- Molgewicht:
- 161.24
- MOL-Datei:
- Mol file
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(R)-2-PHENYLPIPERIDINE Eigenschaften
- Siedepunkt:
- 257.3±19.0 °C(Predicted)
- Dichte
- 0.967±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.74±0.10(Predicted)
- Aggregatzustand
- liquid
- Aussehen
- Colorless to light yellow Liquid
- InChI
- 1S/C11H15N/c1-2-6-10(7-3-1)11-8-4-5-9-12-11/h1-3,6-7,11-12H,4-5,8-9H2/t11-/m1/s1
- InChIKey
- WGIAUTGOUJDVEI-LLVKDONJSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| HS Code |
2933399990 |
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| Speicherklasse |
10 - Combustible liquids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(R)-2-PHENYLPIPERIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
(R)-2-Phenylpiperidine is an alkene that has been used in the desymmetrization of secondary amides to produce enantiopure products. It has been shown to be stereoselective. It could prepared from δ-Amino β-keto esters 3. The kinetic resolution of this compound is due to the formation of an enamine, which undergoes a 1,4-addition reaction with an aldoxime or piperidone.
Verwenden
Chiral building block developed using Liverpool ChiroChem-patented technology.
Synthese
In a 10 mL one-necked round-bottomed flask equipped with a magnetic stir bar, rubber septum, and argon balloon was placed 0.033 g (0.19 mmol, 1 equiv.) of (R)-(+)-6-Phenylpiperidin-2-one and THF (1.2 mL). Lithium aluminum hydride (0.95 mL, 1.0 M solution in THF, 0.95 mmol) was added slowly via syringe and the reaction mixture was stirred at rt for 8 h. The solution was cooled to 0 °C, sat. Na2SO4 (0.17 mL) was added, stirred for 0.5 h at rt and the reaction mixture was filtered through Celite. The organic phases were concentrated and flash chromatography (7% MeOH/CH2Cl2) gave 0.025 g (82%) of (R)-2-phenylpiperidine as volatile oil.
(R)-2-PHENYLPIPERIDINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(R)-2-PHENYLPIPERIDINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 60)Lieferanten
- (R)-2-PHENYLPIPERIDINE
- (R)-(+)-6-phenylpiperidine
- Piperidine, 2-phenyl-, (2R)-
- (R)-2-Phenylpiperidine 95%
- (2R)-2-phenylpiperidine
- (R)-2-Phenylpiperidine
- N-methyl-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide
- 58613-54-0
