Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-C₆-PEG₁-C₃-PEG₁-Butyl Iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Xian confluore Biological Technology Co., Ltd.	+86-15680926068	1924344760@confluore.cn	China	2997	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4142	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1640	58
Changsha Bono New Materials Technology Co., Ltd.	18191076804	asherw9@hotmail.com	China	2373	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	9068	58
Merck KGaA	--	ordercn@merckgroup.com	China	6394	58
TargetMol	400-821-0310 15002144251	xuexiang.shao@tsbiochem.com	China	29118	58

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• Pomalidomide-6-5-6-I
• Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
• Hexanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-6-[[5-[(6-iodohexyl)oxy]pentyl]oxy]-
• Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-6-5-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-6-((5-((6-iodohexyl)oxy)pentyl)oxy)hexanamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
• Pomalidomide-C?-PEG?-C?-PEG?-butyl iodide
• N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-6-({5-[(6-iodohexyl)oxy]pentyl}oxy)hexanamide
• Pomalidomide-C₆-PEG₁-C₃-PEG₁-butyl iodide
• 1835705-76-4
• C30H42IN3O7