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4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid

Sotalol hydrochloride Struktur
959-24-0
CAS-Nr.
959-24-0
Bezeichnung:
4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid
Englisch Name:
Sotalol hydrochloride
Synonyma:
SOTALOL HCL;DAROB;SOTALEX;SOTACOR;MJ-1999;BETAPACE;DL-MJ 1999;SOLATOL HCL;Betapace AF;meadjohnson1999
CBNumber:
CB9712098
Summenformel:
C12H20N2O3S.ClH
Molgewicht:
308.83
MOL-Datei:
959-24-0.mol

4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid Eigenschaften

Schmelzpunkt:
218-220°C
storage temp. 
2-8°C
L?slichkeit
H2O: 20 mg/mL
Aggregatzustand
powder
Farbe
white to off-white
Wasserl?slichkeit
Soluble in phosphate buffered saline, DMSO, ethanol, water, and methanol.
Major Application
pharmaceutical small molecule
InChI
InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChIKey
VIDRYROWYFWGSY-UHFFFAOYSA-N
SMILES
C(C1C=CC(=CC=1)NS(=O)(=O)C)(O)CNC(C)C.Cl
CAS Datenbank
959-24-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
WGK Germany  3
RTECS-Nr. PB0826000
HS Code  2935904000
Speicherklasse 11 - Combustible Solids
Toxizit?t LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish)
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).

Chemische Eigenschaften

White Crystalline Solid

Verwenden

Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.

Definition

ChEBI: A hydrochloride salt that is the monohydrochloride of sotalol. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.

Biologische Aktivit?t

A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™ .

4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 265)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20122 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
Hebei Jimi Trading Co., Ltd.
+86 319 5273535
bestoneforyou@sina.com CHINA 287 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8615060885618
sales@amoychem.com China 6366 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9996 58

959-24-0(4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid)Verwandte Suche:


  • 4-(2-isopropylamino-1-hydroxyaethyl)methanesulfonailidhydrochlorid
  • 4’-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilidemonohydrochloride
  • 4’-(1-hydroxy-2-(isopropylamino)ethyl)-methanesulfonanilidmonohydrochlorid
  • isopropylaminohydroxyethylmethanesulfonanilidehydrochloride
  • meadjohnson1999
  • n-isopropyl-beta-(4-methanesulfonamidophenyl)ethanolaminehydrochloride
  • SOTACOR
  • SOTALEX
  • (+/-)-SOTALOL HYDROCHLORIDE
  • SOTALOL HYDROCHLORIDE
  • MJ-1999
  • N-[4-[1-HYDROXY-2-[(1-METHYLETHYL)AMINO]ETHYL]PHENYL]METHANESULFONAMIDE HYDROCHLORIDE
  • N-[4-(1-HYDROXY-2-[ISOPROPYLAMINO]ETHYL)-PHENYL]METHANESULFONAMIDE HYDROCHLORIDE
  • D,L-Sotalol, Hydrochloride
  • MJ-1999, Betapace, Darob, Sotacor, Sotalex
  • 4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide hydrochloride
  • 4'-[2-(Isopropylamino)-1-hydroxyethyl]methanesulfonanilide monohydrochloride
  • DL-MJ 1999
  • Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-, monohydrochloride (9CI)
  • N-Isopropyl-b-(4-methanesulfonamidophenyl)ethanolamine hydrochloride
  • METHANESULPHONANILIDE41HYDROXY2ISOPROPYLAMINOETHYLMONOHYDROCHLORIDE
  • 4'-(1-hydroxy-2-isopropylaminoethyl)methanesulphonanilide hydrochloride
  • BETAPACE
  • DAROB
  • SOLATOL HCL
  • (-N-[4-[1-Hydroxy-2-[(1-Methyl Ethyl) Amino]-ethyl]phenyl]methanesulfonamide
  • SOTALOL HYDROCHLORIDE BP
  • N-4-[1-Hydroxy-2-(isopropylamino)ethyl]methane sulfonanilide hydrochloride
  • Beta-cardone hydrochloride
  • Sotalol Hydrochloride (300 mg)
  • Sotalol hydrochlorid
  • Sotalol (Betapace)
  • Sotalol hydrochloride COS
  • Berlex Laboratories
  • Betapace AF
  • (±)-Sotalol hydrochloride,N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride
  • MethanesulfonaMide,N-[4-[1-hydroxy-2-[(1-Methylethyl)aMino]ethyl]phenyl]-, hydrochloride (1:1)
  • N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-methanesulfonamide,hydrochloride (1:1)
  • Sotalol hydrochloride CRS
  • N-[4-[(1RS)-1-Hydroxy-2-[(1-methylethyl)amino]ethyl]- phenyl]methanesulfonamide hydrochloride
  • (+)-sotalol hydrochloride
  • Sotalol hydrochloride USP/EP/BP
  • Sotalol HCl (MJ 1999)
  • Sotalol HydrochlorideQ: What is Sotalol Hydrochloride Q: What is the CAS Number of Sotalol Hydrochloride Q: What is the storage condition of Sotalol Hydrochloride Q: What are the applications of Sotalol Hydrochloride
  • Sotalol Hydrochloride (1617408)
  • Sotalol hydrochloride in methanol
  • C16972630 SotaloLhydrochloride
  • Sotalol HCl - Bio-X ?
  • Sotalol hydrochloride 100 μg/mL in Acetonitrile
  • Sotalol Hydrochloride 1.0 mg/ml in Methanol (as free base)
  • SOTALOL HCL
  • 959-24-0
  • C21H21ClN2O3S
  • C12H20N2O3SxHCl
  • C12H20N2O3SClH
  • C12H21ClN2O3S
  • C12H20N2O3SHCl
  • EXCENEL
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