ANTI-PHOSPHO-LCK (PTYR505) Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

A working concentration of 0.1-1.0 μg/mL is recommended for detection of human Lck protein by immunoblotting.

Allgemeine Beschreibung

The signalling in T cells is mediated by receptor and non-receptor protein tyrosine kinases (PTK). Among the family of non-receptors PTK, Lck is a lymphoid-specific cytosolic PTK essential for T-cell development and function. Lck is essential for selection and maturation of developing T cells in the thymus. It plays a significant role in T-cell receptors mediated signalling by constitutive association with CD4 and CD8 receptors. In addition, Lck undergoes phosphorylation and activation by association with CD2 molecule. Lck also plays a role in T-cell proliferation in response to IL-2 receptor pathway. The activity of Lck is known to be regulated by phosphorylation of two conserved tyrosine residues, tyrosine 505 (equivalent to tyrosine 529 in c-Src) and tyrosine 394 (equivalent to tyrosine 418 in c-Src). Phosphorylation at Tyr505 stabillizes Lck and renders it biologically inactive.
Anti-phospho Lck (pTyr⁵⁰⁵) specifically recognizes human Lck (pTyr⁵⁰⁵). Mouse (100% homology) and chicken (91.7% homology) are expected to react.

ANTI-PHOSPHO-LCK (PTYR505) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ANTI-PHOSPHO-LCK (PTYR505) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Riedel-de Haen AG	--		United States	6773	87
SIGMA-RBI	--		Switzerland	6896	91

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• Anti-phospho-Lck (pTyr505) antibody produced in rabbit
• Anti-lymphocyte-specific protein tyrosine kinase antibody produced in rabbit
• Anti-p56lck antibody produced in rabbit
• Anti-pp58lck antibody produced in rabbit
• Anti-YT16 antibody produced in rabbit
• ANTI-PHOSPHO-LCK (PTYR505)
• LAntibodies for Kinase/Phosphatase Biology
• Lymphocyte Specific Kinase (Lck)
• Alphabetical Index
• Antibodies
• Non-Receptor Tyrosine Kinase Antibodies