BUTYROLACTONE I
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- CAS-Nr.
- 87414-49-1
- Englisch Name:
- BUTYROLACTONE I
- Synonyma:
- OloMoucin;BUTYROLACTONE I;Butyrolactone I - CAS 87414-49-1;Butyrolactone I, ATP-competitive cyclin-dependent kinase (CDK) inhibitor;2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester;2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-
- CBNumber:
- CB9717987
- Summenformel:
- C24H24O7
- Molgewicht:
- 424.44
- MOL-Datei:
- 87414-49-1.mol
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BUTYROLACTONE I Eigenschaften
- Schmelzpunkt:
- 74℃
- Siedepunkt:
- 660.1±55.0 °C(Predicted)
- Dichte
- 1.353±0.06 g/cm3(Predicted)
- RTECS-Nr.
- LU0221600
- storage temp.
- Store at -20°C
- L?slichkeit
- Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml
- Aggregatzustand
- White solid.
- pka
- 8.59±0.40(Predicted)
- Farbe
- White to off-white
- Sensitive
- Light Sensitive
- InChI
- 1S/C24H24O7/c1-14(2)4-6-17-12-15(5-11-19(17)26)13-30-23(29)24(3)20(21(27)22(28)31-24)16-7-9-18(25)10-8-16/h4-5,7-12,25-27H,6,13H2,1-3H3/t24-/m1/s1
- InChIKey
- FPVUCBMBMUHRDX-XMMPIXPASA-N
BUTYROLACTONE I Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.
Enzyminhibitor
This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.
BUTYROLACTONE I Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
BUTYROLACTONE I Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 43)Lieferanten
87414-49-1()Verwandte Suche:
- BUTYROLACTONE I
- 2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester
- OloMoucin
- 2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-
- Butyrolactone I - CAS 87414-49-1
- Butyrolactone I, ATP-competitive cyclin-dependent kinase (CDK) inhibitor
- 87414-49-1
- Antibiotic
