Zofenopril calcium
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- CAS-Nr.
- 81938-43-4
- Englisch Name:
- Zofenopril calcium
- Synonyma:
- ZOFENOPRIL CALCIUM SALT;Bifril;Zofenil;SQ26991;Zoprace;Bifril-d5;Zofenil-d5;SQ26991;ZOPRACE;ZOFENOPRIL CALCIUM;Zofenopril Calciun Salt
- CBNumber:
- CB9789184
- Summenformel:
- C22H25CaNO4S2
- Molgewicht:
- 471.64
- MOL-Datei:
- 81938-43-4.mol
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Zofenopril calcium Eigenschaften
- Schmelzpunkt:
- >250°C
- alpha
- D23 -67.6° (c = 1 in methanol/HCl)
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- DMSO: >5mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- CAS Datenbank
- 81938-43-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
N |
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| R-S?tze: |
50/53 |
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| S-S?tze: |
60-61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| HS Code |
2933.99.5300 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
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P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Zofenopril calcium Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Zofenopril calcium was introduced as a second-generation angiotensinconverting
enzyme (ACE) inhibitor for the treatment of acute myocardial infarction.
Zofenopril, rapidly hydrolyzed by cardiac esterase, is actually a S-benzoyl prodrug of the
active component zofenopril-sulfhydryl (zofenoprilat), the latter being the ACE inhibitor
responsible for the improvement of postischemic contractile function and for the reduction
of cardiac cell death. It was suggested that ACE inhibition alone was not sufficient to
explain the cardioprotective effects; the antioxidant properties demonstrated in vitro and in
viva could partly explain the strong anti-ischemic effects. In rats with CHF after myocardial
infarction, zofenopril attenuated ventricular enlargement and cardiac hypertrophy. It was
also shown in isolated globally ischemic rat hearts that the cardioprotective effect of
zofenopril was stereoselective. Clinical studies in healthy volunteers comparing zofenopril
with enalapril demonstrated that the rate of hydrolysis of the former was faster; at 30 or 60
mg, ACE was completely inhibited in most volunteers until 12h after administration. In
patients with anterior acute myocardial infarction, a g-week treatment with zofenopril
significantly reduced the incidence of death or severe CHF and also improved the chance
of surviving the next year.
Chemische Eigenschaften
Off-White to Light Yellow Crystalline Solid
Verwenden
Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat
Definition
ChEBI: An organic calcium salt that is the hemicalcium salt of zofenopril. A prodrug for zofenoprilat.
Zofenopril calcium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Zofenopril calcium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 188)Lieferanten
81938-43-4()Verwandte Suche:
- L-Proline,1-[(2S)-3-(benzoylthio)-2-Methyl-1-oxopropyl]-4-(phenylthio)-, calciuM salt(2:1), (4S)-
- Zofenopril calcium, >=98.5%
- (4S)-1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline calcium salt
- ZOFENOPRIL CALCIUM
- [1(S),4(S)]-1-(3-Mercapto-2-methyl-1-oxopropyl)-4-phenyl-thio-L-proline-S-benzoyl Ester Calcium Salt
- Bifril
- Zofenil
- (4s)-n-[3-(benzoylsulfanyl)-2(s)-methylpropionyl]-4-(phenylsulfanyl)-l-proline calcium salt
- [(4S)-(2S)-3-(benzoylthio)-2-methylpro-pionyl-4-(phenylthio)-L-prolinelcalcium
- ZOFENOPRILCALCIUMSALT(FORRESEARCHONLY)
- Zofenopril Calciun Salt
- (4S)-(2S)-3-(BENZOYLTHIO)-2-METHYLPRO-PIONYL-4 -(PHENYLTHIO)-L-PROLINEL CALCIUM SALT
- Bifril-d5
- [1(S),4(S)]-1-(3-Mercapto-2-Methyl-1-oxopropyl)-4-phenyl-thio-L-proline-S-benzoyl-d5 Ester CalciuM Salt
- Zofenil-d5
- SQ26991
- SQ26991;ZOPRACE
- Zoprace
- Zofenopril calcium USP/EP/BP
- Zofenopril calcium Impurities
- Zofenopril calciumQ: What is
Zofenopril calcium Q: What is the CAS Number of
Zofenopril calcium Q: What is the storage condition of
Zofenopril calcium Q: What are the applications of
Zofenopril calcium
- Calcium (2S,4S)-1-((S)-3-(benzoylthio)-2-methylpropanoyl)-4-(phenylthio)pyrrolidine-2-carboxylate
- Zofenopril calcium, 10 mM in DMSO
- ZOFENOPRIL CALCIUM SALT
- 81938-43-4
- C44H44CaN2O8S4
- C22H22NO4S205Ca
- C22H22NO4S2Ca
- 2C22H22NO4S2Ca
- C22H22NO4S212Ca
- All Inhibitors
- Inhibitors
- Intermediates & Fine Chemicals
- MTS & Sulfhydryl Active Reagents
- Pharmaceuticals
- API
