2-Fluoroadenine
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- CAS-Nr.
- 700-49-2
- Englisch Name:
- 2-Fluoroadenine
- Synonyma:
- 2-Fluoro-9H-purin-6-amine;2-fluoro-7H-purin-6-aMine;2-fad;nsc27364;uoroadenine;TCMDC-124283;2-fluoro-adenin;2-FLUOROADENINE;BUTTPARK 25\01-01;2-Fluoroadenine>
- CBNumber:
- CB9854134
- Summenformel:
- C5H4FN5
- Molgewicht:
- 153.12
- MOL-Datei:
- 700-49-2.mol
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2-Fluoroadenine Eigenschaften
- Schmelzpunkt:
- >350 °C(lit.)
- Siedepunkt:
- 239.6±50.0 °C(Predicted)
- Dichte
- 2.05±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Sparingly, Sonicated, Heated), Methanol (Slightly, Heated)
- Aggregatzustand
- Solid
- pka
- 6.84±0.20(Predicted)
- Farbe
- White to Light Yellow
- InChI
- InChI=1S/C5H4FN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)
- InChIKey
- WKMPTBDYDNUJLF-UHFFFAOYSA-N
- SMILES
- N1C2C(=NC(F)=NC=2N)NC=1
- CAS Datenbank
- 700-49-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi,Xn |
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| R-S?tze: |
36/37/38-22 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
AU6264700 |
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| Hazard Note |
Irritant |
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| HazardClass |
IRRITANT, IRRITANT-HARMFUL |
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| HS Code |
29335990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2-Fluoroadenine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2-Fluoroadenine is a purine nucleoside analog which has been investigated for suicide gene therapy for human malignancy. It has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro. It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 μM.
Chemische Eigenschaften
white to light yellow crystal powder
Verwenden
2-Fluoroadenine is a fluorinated heterocyclic 2-ring compound. It is the base moiety for many carbocyclic and acyclic nucleoside analogues, which may be used in antineoplastic studies. 2-Fluoroadenine has been used as an intermediate for antineoplastic drugs such as fludarabine. fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia.
Definition
ChEBI: 2-fluoroadenine is an organofluorine compound that is adenine in which the hydrogen at position 2 (the carbon between the two nitrogens of the pyrimidine ring) is replaced by a fluorine. It has a role as an antineoplastic agent. It is an organofluorine compound and a member of purines.
2-Fluoroadenine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Fluoroadenine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 389)Lieferanten
700-49-2()Verwandte Suche:
- 2-fluoro-1h-purin-6-amin
- 2-fluoro-1h-purin-6-amine
- 2-fluoro-adenin
- 6-amino-2-fluoro-purin
- nsc27364
- 6-Amino-2-fluoro-1H-purine
- BUTTPARK 25\01-01
- 2-FLUORO-6-AMINOPURINE
- 2-FLUOROADENINE
- 2-FLUORO-7(9)H-PURIN-6-YLAMINE
- 6-AMINO-2-FLUOROPURINE
- 2-Fluoro-9H-purin-6-amine, 2-Fluoroadenine
- 6-Amino-2-fluoro-9H-purine
- 2-fad
- Fludarabine Phosphate EP Impurity D
- Fludarabine Phosphate Impurity 4
- uoroadenine
- Fludarabine Phosphate impurity 4/Fludarabine Phosphate EP Impurity D/2-fluoroadenine
- Fludarabine EP impurity D (2-Fluoroadenine )
- Fludarabine EP impurity D
- Fludarabine Phosphate Impurity 4（Fludarabine Phosphate EP Impurity D）
- 2-Fluoroadenine>
- 9H-Purin-6-amine, 2-fluoro-
- 2-Fluoroadenine USP/EP/BP
- 2-Fluoroadenine(700-49-2)
- Fludarabine Impurity 5
- 2-fluoro-7H-purin-6-aMine
- TCMDC-124283
- 2-Fluoro-7H-purin-6-amine (2-Fluoroadenine)
- 2-Fluoroadenine, 10 mM in DMSO
- 2-Fluoro-9H-purin-6-amine
- 700-49-2
- C5H4FN5
- C5H4N5F
- Purines
- Heterocyclic Building Blocks
- Building Blocks
- Biochemistry
- Nucleobases and their analogs
- Nucleosides, Nucleotides & Related Reagents
- Purine
- Chemical Amines
- Purines
- Bases & Related Reagents
- Heterocycles
- Nucleotides
- Fused Ring Systems
- Miscellaneous
- Amines
- bc0001
