ARV110

2222112-77-6

CAS-Nr.: 2222112-77-6

Englisch Name:: ARV110

Synonyma:: ARV-110;Bavdegalutamide;Bavdegalutamide (ARV-110);Bavdegalutamide (ARV-110) ，S6965;3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]...;prostate,castration-resistant prostate cancer,receptor,ARV 110,androgen,Bavdegalutamide,Androgen Receptor,inhibit,cancer,ARV110,Inhibitor,metastatic;N-(trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide;N-((1R,4R)-4-(3-chloro-4-cyanophenox y)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopip eridin-3-yl)-6-fluoro-1,3-dioxoisoindoli n-5-yl)piperazin-1-yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide;3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-

CBNumber:: CB98715291

Summenformel:: C41H43ClFN9O6

Molgewicht:: 812.29

MOL-Datei:: 2222112-77-6.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 96

ARV110 Eigenschaften

Siedepunkt:: 1074.1±65.0 °C(Predicted)

Dichte: 1.49±0.1 g/cm3(Predicted)

storage temp.: Store at-20°C, away from moisture

L?slichkeit: DMSO : 26.67 mg/mL (32.83 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C)

pka: 10.59±0.40(Predicted)

Aggregatzustand: Solid

Farbe: Light yellow to yellow

InChIKey: CLCTZVRHDOAUGJ-SYVGMNBRSA-N

SMILES: C1(C(N[C@@H]2CC[C@@H](OC3=CC=C(C#N)C(Cl)=C3)CC2)=O)=NN=C(N2CCC(CN3CCN(C4C(F)=CC5=C(C=4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)C=C1

Sicherheit

ARV110 Chemische Eigenschaften,Einsatz,Produktion Methoden

Charakteristisch

ARV-110 is a PROteolysis TArgeting Chimera (PROTAC) protein degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the polyubiquitination and subsequent proteasomal degradation of AR. It selectively degrades wild-type AR and most clinically relevant mutants with low nanomolar potency.

ARV110 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ARV110 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 96)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Xi an Biohorlden Industry Trade Co Ltd	+86-18829283179 +86-13636819721	sales@horlden.com	China	334	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	9947	58
Sichuan Biosynce Pharmatech Co., Ltd.	+8619950309693	diane@biosynce.com	China	4871	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58

3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-
N-((1R,4R)-4-(3-chloro-4-cyanophenox y)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopip eridin-3-yl)-6-fluoro-1,3-dioxoisoindoli n-5-yl)piperazin-1-yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide
N-(trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide
Bavdegalutamide (ARV-110)
3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]...
prostate,castration-resistant prostate cancer,receptor,ARV 110,androgen,Bavdegalutamide,Androgen Receptor,inhibit,cancer,ARV110,Inhibitor,metastatic
Bavdegalutamide (ARV-110) ，S6965
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide
ARV-110
Bavdegalutamide
2222112-77-6
C41H43ClFN9O6

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