Methysergid Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Methysergide (Methylergonovine EP Impurity G) is a serotonergic receptor antagonist.
Clinical Use
Methysergide (Sansert), which is structurally identical to methylergonovine except for the addition of a methyl group to the indole nitrogen, has far less of the uterine
stimulatory properties of the other agents and, instead, is used exclusively for treatment of migraine headache as a serotonin antagonist at 5-HT1/5-HT2 receptors.Methysergide is a potent peripheral inhibitor of 5-HT receptors in the blood vessel, which inhibits vessel-wall permeability. Methysergide also inhibits the release of
histamine from mast cells and stabilizes platelets against the release of 5-HT, which may be responsible for the onset of the migraine attack. In contrast to its
peripheral effects, methysergide appears to be a central 5-HT1 agonist, resulting in alleviation of the central hyperalgesia effect that occurs in patients with migraine.
Methysergid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
