4-(3-fluoro-benzyloxy)-benzaldehyde
- CAS No.
- 66742-57-2
- Chemical Name:
- 4-(3-fluoro-benzyloxy)-benzaldehyde
- Synonyms
- Safinamide Intermediate 1;4-(3-Fluorbenzyloxy)benzaldehyd;Safinamide mesylate Intermediate;Safinamide mesylate Intermediate 1;4-(3-Fluorobenzyloxy)benzaldehyde >4-[(3-fluorophenyl)methoxy]-Benzaldehyde;Benzaldehyde, 4-[(3 -fluorophenyl)Methoxy]-;4-(3-FLUORO-BENZYLOXY)-BENZALDEHYDE Intermediate 1;4-(3-FLUORO-BENZYLOXY)-BENZALDEHYDE ISO 9001：2015 REACH;4-(3-Fluoro-benzyloxy)benzaldehyde, 4-(3-Fluoro- benzyloxy)benzaldehyde
- CBNumber:
- CB01010457
- Molecular Formula:
- C14H11FO2
- Molecular Weight:
- 230.23
- MDL Number:
- MFCD02605317
- MOL File:
- 66742-57-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-(3-Fluorobenzyloxy)benzaldehyde >98.0%(GC) | F0943 | 1g | $89 |
| 4-(3-Fluorobenzyloxy)benzaldehyde >98.0%(GC) | F0943 | 5g | $314 |
| 4-((3-Fluorobenzyl)oxy)benzaldehyde 98% | AS57469 | 1g | $25 |
| 4-((3-Fluorobenzyl)oxy)benzaldehyde 98% | AS57469 | 5g | $53 |
| 4-((3-Fluorobenzyl)oxy)benzaldehyde 98% | AS57469 | 25g | $169 |
| More product size | |||
| Melting point | 46.0 to 50.0 °C |
|---|---|
| Boiling point | 265°C/3mmHg(lit.) |
| Density | 1.211±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | Solid:crystalline |
| color | White to Almost white |
| InChI | InChI=1S/C14H11FO2/c15-13-3-1-2-12(8-13)10-17-14-6-4-11(9-16)5-7-14/h1-9H,10H2 |
| InChIKey | DNKSIIHRKWTIRH-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC=C(OCC2=CC=CC(F)=C2)C=C1 |
| CAS DataBase Reference | 66742-57-2 |
| FDA UNII | F835Z6XML4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2913.00.4000 |
| HazardClass | IRRITANT |
| REACH Registrations | Active |
4-(3-fluoro-benzyloxy)-benzaldehyde price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0943 | 4-(3-Fluorobenzyloxy)benzaldehyde >98.0%(GC) | 66742-57-2 | 1g | $89 | 2026-04-30 | Buy |
| TCI Chemical | F0943 | 4-(3-Fluorobenzyloxy)benzaldehyde >98.0%(GC) | 66742-57-2 | 5g | $314 | 2026-04-30 | Buy |
| Activate Scientific | AS57469 | 4-((3-Fluorobenzyl)oxy)benzaldehyde 98% | 66742-57-2 | 1g | $25 | 2026-06-04 | Buy |
| Activate Scientific | AS57469 | 4-((3-Fluorobenzyl)oxy)benzaldehyde 98% | 66742-57-2 | 5g | $53 | 2026-06-04 | Buy |
| Activate Scientific | AS57469 | 4-((3-Fluorobenzyl)oxy)benzaldehyde 98% | 66742-57-2 | 25g | $169 | 2026-06-04 | Buy |
4-(3-fluoro-benzyloxy)-benzaldehyde Chemical Properties,Uses,Production
Chemical Properties
4-(3-fluorobenzyloxy)benzaldehyde is white to off-white solid at room temperature and pressure, it is a benzaldehyde derivative, and it is easy to be oxidized by air to produce the corresponding benzoic acid compounds when stored for a long time at room temperature, therefore, it is generally required to be stored under low temperature (2 to 8 degrees).
Uses
4-(3-Fluorobenzyloxy)benzaldehyde is useful for organic reactions and synthesis.
Synthesis
4-(3-fluoro-benzyloxy)-benzaldehyde is synthesized by the reaction of 4-Hydroxybenzaldehyde with 3-fluorobenzyl bromide. 4-Hydroxybenzaldehyde, 3-fluorobenzyl bromide, potassium carbonate, and acetone were sequentially added to a single-neck round bottom flask. Reaction at 60 ° C for 5 h. Cool to room temperature, filter, and collect the filtrate.Purification by direct column chromatography. 4-(3-fluoro-benzyloxy)-benzaldehyde was obtained as a white solid (1.78 g, 94.4%).
References
[1] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 80-81
[2] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 81
[3] Patent: WO2007/147491, 2007, A1. Location in patent: Page/Page column 44-45
[4] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 57-58
[5] Patent: CN106220525, 2016, A. Location in patent: Paragraph 0013; 0014; 0019
4-(3-fluoro-benzyloxy)-benzaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 4-(3-fluoro-benzyloxy)-benzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-15 | 4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2
|
1kg | ＞98% by HPLC | 200kg/month | Zison Pharmaceutical (Shandong) Co., Ltd. | ||
 |
2025-04-04 | 4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2022-02-25 | 4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2
|
1KG | 98% | 100kg | Jinan Ande Pharmaceutical Co.,Ltd. |
-
- 4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2
- ＞98% by HPLC
- Zison Pharmaceutical (Shandong) Co., Ltd.
-
- 4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2
- $0.00
- 98%
- Jinan Ande Pharmaceutical Co.,Ltd.
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