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2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate

2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate structure

CAS No.: 134877-42-2

Chemical Name:: 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate

Synonyms: T8;2-Deoxy-2,2-difluoro-alpha-D-erythro-pentofuranose 3,5-dibenzoate 1-Methanesulfonate;Gemcitabine impurity 2/2-Deoxy-2,2-difluoro-3,5-dibenzoate-1-methanesulfonate α-D-erythro-Pentofuranose;Ly-2;Ly-B;Lyt2;Ly-35;Lyt-2;-3-(Benzoyloxy);((2R,3R,5R)-3-(benzoyloxy)-

CBNumber:: CB01075243

Molecular Formula:: C20H18F2O8S

Molecular Weight:: 456.41

MDL Number:: MFCD09842850

MOL File:: 134877-42-2.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:42

Product description	Number	Pack Size	Price
3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 75% alpha purity	MD71568	50g	$150
3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 75% alpha purity	MD71568	25g	$150
3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 75% alpha purity	MD71568	100g	$155
3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 98% alpha purity	MD08302	5g	$172.35
3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 75% alpha purity	MD71568	250g	$310
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2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate Properties

Boiling point	588.4±50.0 °C(Predicted)
Density	1.46
storage temp.	2-8°C
Appearance	White to off-white Solid

2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	MD71568	3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 75% alpha purity	134877-42-2	50g	$150	2026-06-04	Buy
Biosynth	MD71568	3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 75% alpha purity	134877-42-2	25g	$150	2026-06-04	Buy
Biosynth	MD71568	3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 75% alpha purity	134877-42-2	100g	$155	2026-06-04	Buy
Biosynth	MD08302	3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 98% alpha purity	134877-42-2	5g	$172.35	2026-06-04	Buy
Biosynth	MD71568	3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 75% alpha purity	134877-42-2	250g	$310	2026-06-04	Buy

Product number	Packaging	Price	Buy
MD71568	50g	$150	Buy
MD71568	25g	$150	Buy
MD71568	100g	$155	Buy
MD08302	5g	$172.35	Buy
MD71568	250g	$310	Buy

2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate Chemical Properties,Uses,Production

Uses

2-Deoxy-2,2-difluoro-3,5-dibenzoate-1-methanesulfonate α-D-erythro-Pentofuranose is an impurity of Gemcitabine (G305028), a potential anticancer agent.

Synthesis

124-63-0

2-deoxy-2,2-difluoro-D-erythro-Pentofuranose-3,5-dibenzoate

1173824-58-2

2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate

134877-42-2

((2R,3R)-3-(Benzoyloxy)-4,4-difluoro-5-hydroxytetrahydrofuran-2-yl)methyl benzoate (4.14 g, 10.9 mmol) was dissolved in anhydrous dichloromethane (52 mL), anhydrous triethylamine (2.4 mL) was added and the solution was cooled to 0 °C. Methylsulfonyl chloride (1.23 mL, 15.8 mmol) was added slowly and dropwise with stirring. The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the mixture was transferred to a partition funnel and partitioned with methylene chloride (140 mL) and saturated sodium bicarbonate solution (56 mL). The organic phase was separated, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give an oily product as a mixture of isoheads (5.03 g, quantitative yield). The chemical shifts were analyzed by 19F NMR (CDCl3, 471 MHz) and were δ -107.770, -108.22, -120.65, -121.17, -122.21, -122.73, -123.76, -124.45.1H NMR (CDCl3, 500 MHz) data of the main isocaprolite (60%): δ 8.13-8.04 (m, 4H, benzoyl), 7.65-7.54 (m, 2H, benzoyl), 7.50-7.41 (m, 4H, benzoyl), 6.17 (d, J=5.6 Hz, 1H, H-1), 5.62 (dd, J1=4.2 Hz, J2=16.4 Hz, 1H, H-3), 4.91 (q, J= 3.9 Hz, 1H, H-4), 4.81-4.61 (m, 2H, H-5), 3.17 (s, 3H, CH3). 1H NMR (CDCl3, 500MHz) data of the minor isohead (40%): δ 8.13-8.04 (4H, m, benzoyl), 7.65-7.54 (m, 2H, benzoyl), 7.50-7.41 (m, 4H, benzoyl), 6.09 (d, J=6.4Hz, 1H, H-1), 5.98 (dt, J1 = 7.3 Hz, J2=15.0 Hz, 1H, H-3), 4.81-4.61 (m, 3H, H-4, H-5), 3.03 (s, 3H, CH3).13C NMR (CDCl3, 126 MHz) data: δ 40.09, 40.20 (CH3), 62.52, 63.08 (C-5), 69.61 (dd ), 71.04 (dd, J1C-F=15.7 Hz, J2C-F=26.0 Hz, C-3), 79.68, 79.75, 82.59 (C-4), 98.81 (dd, J1C-F=25.0 Hz, J2C-F=41.8 Hz, C-1), 99.52 (dd, J1C-F=25.0 Hz, J2C-F=41.8 Hz, C-1), 99.52 (dd, J1C-F=25.0 Hz, J2C-F=41.8 Hz C-1), 99.52 (dd, J1C-F=24.5Hz, J2C-F=46.3Hz, C-1), 120.61 (dd, J1C-F=253.5Hz, J2C-F=269.8Hz, C-2), 120.91 (dd, J1C-F=249.3Hz, J2C-F=276.3Hz, C-2) , 128.42, 128.58, 128.63, 128.70, 128.76, 128.79 (benzene ring), 129.18, 129.25 ('ipso' benzene ring), 129.76, 130.07, 130.14, 133.51, 133.63, 134.19, 134.26 (benzene ring), 164.89 , 165.03, 165.81, 165.90 (carbonyl).

References

[1] Synthesis, 1992, # 6, p. 565 - 570
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 14, p. 4338 - 4345
[3] Patent: WO2009/61781, 2009, A1. Location in patent: Page/Page column 102-103
[4] Biochemistry, 2010, vol. 49, # 7, p. 1404 - 1417
[5] Patent: WO2005/95430, 2005, A1. Location in patent: Page/Page column 18

2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate Preparation Products And Raw materials

Raw materials

Methanesulfonyl chloride 2-deoxy-2,2-difluoro-D-erythro-Pentofuranose-3,5-dibenzoate Dichloromethane Triethylamine

Preparation Products

4-Amino-1-3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate

2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate Suppliers

Global( 118)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4017	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20581	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9539	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Lianyungang happen teng technology co., LTD	58
career henan chemical co	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58

View Lastest Price from 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-30	2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate 134877-42-2	$7.00	1KG	99%	100KG	Career Henan Chemical Co

2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate
134877-42-2
$7.00
99%
Career Henan Chemical Co

134877-42-2(2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate)Related Search:

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DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* methanesulfonate 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate

1of4

((2R,3R,5S)-3-(Benzoyloxy)-4,4-difluoro-5-((methyl-sulfonyl)oxy)tetrahydrofuran-2-yl)methyl benzo -3-(Benzoyloxy) -4,4-difluoro-5-((methylsulfonyl) ((2R,3R,5S)-3-(Benzoyloxy)-4,4-difluoro-5-((methyl-sulfonyl)oxy)tetrahydrofuran-2-yl)methyl be 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate ((2R,3R,5R)-3-(Benzoyloxy)-4,4-difluoro-5-((Methylsulfonyl)oxy)tetrahydrofuran-2-yl)Methyl benzoate ((2R,3R,5S)-3-(benzoyloxy)-4,4-difluoro-5-((Methylsulfonyl)oxy)tetrahydrofuran-2-yl)Methyl benzoate ((2R,3R,5R)-3-(benzoyloxy)- 3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 75% alpha purity 3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-a-D-ribofuranoside - 98% alpha purity 3,5-Bis(benzoyl)-1-methanesulfonyloxy-2-deoxy-2,2-difluororibose(α-form) 2-Deoxy-2,2-difluoro-3,5-dibenzoate-1-methanesulfonate α-D-erythro-Pentofuranose 3,5-Bis(benzoyl)-1-methanesulfonyloxy-2-deoxy-2,2-difluorori... 134877-42-2 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate 2-Deoxy-2,2-difluoro-alpha-D-erythro-pentofuranose 3,5-dibenzoate 1-Methanesulfonate Gemcitabine impurity 2/2-Deoxy-2,2-difluoro-3,5-dibenzoate-1-methanesulfonate α-D-erythro-Pentofuranose α-D-erythro-Pentofuranose, 2-deoxy-2,2-difluoro-, 3,5-dibenzoate 1-methanesulfonate alpha-2-deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-α-D-ribofuranoside 2-Deoxy-2,2-difluoro-D-ribofuranosyl-3,5-dibenzoyl-1-methanesulfonate Ly-2 Ly-35 Ly-B Lyt2 Lyt-2 T8 134877-42-2 1211-11-9 122-11-9 C20H18O8SF2 Antineoplastic drug, difluorine nucleoside analog

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