GOITRINE
- CAS No.
- 1072-93-1
- Chemical Name:
- GOITRINE
- Synonyms
- Epigoitrin;GOITRINE;R-GOITRIN;D-Goitrin;Epigotrin;BA-51-090278;R、Sepigoitrin;Goitrine Epigoitrin;Epigoitrin/(R,S)-goitrin;5-VINYL-2-THIOOXAZOLIDONE
- CBNumber:
- CB01410433
- Molecular Formula:
- C5H7NOS
- Molecular Weight:
- 129.18
- MDL Number:
- MFCD01709801
- MOL File:
- 1072-93-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Epigoitrin ≥98% | 35620 | 5mg | $55 |
| Epigoitrin ≥98% | 35620 | 10mg | $98 |
| Epigoitrin ≥98% | 35620 | 25mg | $218 |
| Epigoitrin ≥99% | 300225 | 20mg | $446 |
| Epigoitrin | Q-100044 | 0.025g | $333.62 |
| More product size | |||
| Melting point | 47.5°C |
|---|---|
| Boiling point | 150.6±43.0 °C(Predicted) |
| Density | 1.170 (estimate) |
| refractive index | 1.5480 (estimate) |
| storage temp. | Amber Vial, -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | solid |
| pka | 13.34±0.40(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C5H7NOS/c1-2-4-3-6-5(8)7-4/h2,4H,1,3H2,(H,6,8)/t4-/m1/s1 |
| InChIKey | UZQVYLOFLQICCT-SCSAIBSYSA-N |
| SMILES | O1[C@H](C=C)CNC1=S |
| FDA UNII | 2N815D740R |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | WGK 3 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | mouse,LD50,unreported,1260mg/kg (1260mg/kg),Journal of Agricultural and Food Chemistry. Vol. 17, Pg. 483, 1969. |
GOITRINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 35620 | Epigoitrin ≥98% | 1072-93-1 | 5mg | $55 | 2026-04-30 | Buy |
| Cayman Chemical | 35620 | Epigoitrin ≥98% | 1072-93-1 | 10mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 35620 | Epigoitrin ≥98% | 1072-93-1 | 25mg | $218 | 2026-04-30 | Buy |
| Usbiological | 300225 | Epigoitrin ≥99% | 1072-93-1 | 20mg | $446 | 2026-06-03 | Buy |
| Biosynth | Q-100044 | Epigoitrin | 1072-93-1 | 0.025g | $333.62 | 2026-06-04 | Buy |
GOITRINE Chemical Properties,Uses,Production
Chemical Properties
Derived from the root of Isatis indigotica Fort.
Uses
Goitrine is a cyclic thiocarbamate that is seen reducing production of thyroid hormones.
Definition
ChEBI: (R)-goitrin is a 5-ethenyl-1,3-oxazolidine-2-thione that has R-configuration. It is a constituent of a traditional Chinese herbal medicine, Radix isatidis. It has a role as an antiviral agent and a plant metabolite. It is an enantiomer of a (S)-goitrin.
Biological Activity
Epigoitrin is a sulfur containing alkaloid isolated from Isatis indigotica (Ban Lan Gen) th at exhibits antiviral, anticancer, and antithyroid activities. Epigoitrin significantly decreases the susceptibility of restraint mice to H1N1 influenza virus. Epigoitrin and goitrin appear to show virucidal effect on influenza virus A (H1N1) in vitro and in ovo.
in vivo
Epigoitrin (88-176 mg/kg/d; oral administration; once daily; for 7 consecutive days) reduces the susceptibility of mice to influenza virus in a restraint - stress - induced H1N1 virus - infected mouse model, manifested as reduced mortality, attenuated inflammation, and decreased viral replication in the lungs[1].
Epigoitrin (50-100 mg/kg; added to the feed; for 12 weeks) reduces fat deposition, improves glucose tolerance and insulin sensitivity, and increases energy expenditure in a high-fat diet-induced obese mouse model[3].
| Animal Model: | Five-week-old male C57BL/6J mice were fed a high-fat diet to establish an obesity model[3]. |
| Dosage: | 50 mg/kg, 100 mg/kg |
| Administration: | Added to the feed, continuously administered for 12 weeks |
| Result: | Reduced fat deposition in HFD mice. Reduced adipocyte hypertrophy. Alleviated hepatic steatosis, as shown by reduced liver lipid droplets and lower liver and serum TG and TC levels. Had no effect on food intake. |
| Animal Model: | Specific-pathogen-free male Kunming mice (4 weeks of age; 12-15 g) loaded with restraint stress[1] |
| Dosage: | 88 mg/kg, 176 mg/kg |
| Administration: | Oral administration, once daily, for 7 days |
| Result: | Increased the survival rate, prolonged the mean day to death, and reduced the morbidity sign. Significantly decreased the virus titer in the lungs, reduced the infiltration of inflammatory cells in the lungs, and lowered the levels of TNF-α and IL-1β in bronchoalveolar lavage fluid. Increased the protein expressions of MAVS, IFN-β, and IFITM3 in the lung tissue, and decreased the protein level of MFN2 and virus nucleoprotein (NP) in stressed mice. |
target
Influenza virus
GOITRINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3992 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 4616 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
View Lastest Price from GOITRINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Epigoitrin
1072-93-1
|
$31.00-89.00 | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-24 | GOITRINE
1072-93-1
|
1KG | 98.0% | 10 | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2023-02-24 | Epigoitrin
1072-93-1
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Epigoitrin
1072-93-1
- $31.00-89.00
- 99.98%
- TargetMol Chemicals Inc.
-
- GOITRINE
1072-93-1
- $0.10
- 98.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Epigoitrin
1072-93-1
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
