1-(2-METHOXY-5-METHYLPHENYL)ETHANONE
- CAS No.
- 20628-07-3
- Chemical Name:
- 1-(2-METHOXY-5-METHYLPHENYL)ETHANONE
- Synonyms
- 2'-METHOXY-5'-METHYLACETOPHENONE;2’-Methoxy-5’-methylacetophenone;Ethanone, 1-(2-methoxy-5-methylphenyl)-;1-(2-methoxy-5-methylphenyl)ethan-1-one;JR-8524, 1-(2-Methoxy-5-methylphenyl)ethanone, 97%;Butanoicacid,2-amino-4-bromo-,(2S)-,hydrobromide(1:3)
- CBNumber:
- CB01490624
- Molecular Formula:
- C10H12O2
- Molecular Weight:
- 164.2
- MDL Number:
- MFCD00156674
- MOL File:
- 20628-07-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2''-METHOXY-5''-METHYLACETOPHENONE AldrichCPR | S883360 | 50MG | $32.7 |
| 1-(2-Methoxy-5-methylphenyl)ethanone | VAA62807 | 5g | $413 |
| 1-(2-Methoxy-5-methylphenyl)ethanone 95% | AS117031 | 1g | $99 |
| 1-(2-Methoxy-5-methylphenyl)ethanone 95% | AS117031 | 5g | $360 |
| 1-(2-Methoxy-5-methylphenyl)ethanone 95% | M52812 | 100mg | $42 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1-(2-METHOXY-5-METHYLPHENYL)ETHANONE price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S883360 | 2''-METHOXY-5''-METHYLACETOPHENONE AldrichCPR | 20628-07-3 | 50MG | $32.7 | 2026-04-30 | Buy |
| Biosynth | VAA62807 | 1-(2-Methoxy-5-methylphenyl)ethanone | 20628-07-3 | 5g | $413 | 2026-06-05 | Buy |
| Activate Scientific | AS117031 | 1-(2-Methoxy-5-methylphenyl)ethanone 95% | 20628-07-3 | 1g | $99 | 2026-06-04 | Buy |
| Activate Scientific | AS117031 | 1-(2-Methoxy-5-methylphenyl)ethanone 95% | 20628-07-3 | 5g | $360 | 2026-06-04 | Buy |
| Synthonix | M52812 | 1-(2-Methoxy-5-methylphenyl)ethanone 95% | 20628-07-3 | 100mg | $42 | 2026-05-06 | Buy |
1-(2-METHOXY-5-METHYLPHENYL)ETHANONE Chemical Properties,Uses,Production
Preparation
Preparation by reaction of acetic acid with 4-methylanisole in the presence of trifluoromethyl-sulfonic anhydride (Tf2O) for 3 min at r.t. (97%).
Synthesis
104-93-8
75-36-5
20628-07-3
General procedure for the synthesis of 1-(2-methoxy-5-methylphenyl)ethanone from p-toluene methyl ether and acetyl chloride: 1. An ethanolic solution of acetyl chloride (6.79 mL, 95.1 mmol) was slowly added dropwise to a 50 mL suspension in dichloromethane containing aluminum chloride (12.69 g, 95.1 mmol) at 0 °C. 2. Subsequently, a solution of 1-methoxy-4-methylbenzene (intermediate LXXXVII) (9.69 g, 79.4 mmol) in 50 mL of dichloromethane was slowly added dropwise to the above reaction mixture.3. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 3 h. 4. Upon completion of the reaction, the reaction was quenched with 1.5 N hydrochloric acid solution and the reaction mixture was extracted with dichloromethane.5. The organic extract was combined and washed sequentially with water and The organic extracts were combined, washed sequentially with water and brine, and then dried over anhydrous sodium sulfate.6 After evaporation of the solvent, the crude product was purified by column chromatography (silica gel 100-200 mesh, eluent ratio 15:85 ethyl acetate:hexane) to afford 1-(2-methoxy-5-methylphenyl)ethanone in 69% yield.7 The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.528 (s, 1H), 7.247 (bs, 1H), 6.852-6.873 (d, 1H, J = 8.4 Hz), 3.881 (s, 3H), 2.601 (s, 3H), 2.299 (s, 3H).
References
[1] Patent: WO2012/90219, 2012, A2. Location in patent: Page/Page column 86
[2] Chemische Berichte, 1928, vol. 61, p. 1999
[3] Vikram, 1959, vol. 3, # 1, p. 1,3
1-(2-METHOXY-5-METHYLPHENYL)ETHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-METHOXY-5-METHYLPHENYL)ETHANONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
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| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15082 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13482353728 | sales@fdc-chemical.com | China | 10000 | 58 |
| Shanghai Maruhua Science and Technology Co. Ltd. | 021-57171708 18721745940 | sales@api-chem.com | China | 1962 | 58 |
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19778 | 58 | |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 3905209149@qq.com | China | 9836 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49312 | 58 |
