一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> iScience >>article
iScience

iScience

IF: 4.6
Download PDF

Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma

Published:3 July 2025 DOI: 10.1016/j.isci.2025.113053
Shun Deng , Rilin Deng , Jinfeng Wang , Qi Hu , Biaoming Xu , Jinhai Zheng , Mingjing Peng , Wenzhi Tan , Haizhen Zhu , Chaohui Zuo

Abstract

The strong immunosuppression and immune evasion of pancreatic ductal adenocarcinoma (PDAC) result in poor efficacy of immune checkpoint blockade. In this study, the PD-1 level on CD8+ T cells in the peripheral blood of patients with PDAC was significantly greater than that in the peripheral blood of healthy individuals. To enhance the anticancer activity of adoptive CD8+ T cells toward PDAC, interferon-α (IFN-α) and thymosin-α1 (Tα1) plus tislelizumab were preclinically explored. Compared with those of tislelizumab monotherapy, the proliferation and cytokine secretion of CD8+ T cells and the cytotoxic activity toward PDAC cells were significantly greater with the combination treatment of IFN-α and Tα1 plus tislelizumab. Moreover, the growth of PDAC tumors was inhibited by CD8+ T cells with high efficacy under the combination treatment. Thus, IFN-α and Tα1 plus tislelizumab enhance the anticancer activity of CD8+ T cells toward PDAC, representing an alternative strategy for improving cancer immunotherapy.

Similar articles

IF:4.9

Immunoreactive thymosin α1 in human thymus and thymoma

Journal of Thoracic and Cardiovascular Surgery Hiroaki Naruse MD, Takahiko Hashimoto MD,etc Published: 1 December 1993
IF:0

Thymosin α1 and thymosin β4 in serum: Comparison of normal, cord, homosexual and AIDS serum

International journal of immunopharmacology Paul H. Naylor , Alvin Friedman-Kien ,etc Published: 1 January 1986
IF:2.5

Maternal and Fetal Circulating Levels of Thymosin α1 During Parturition

American Journal of Reproductive Immunology ROBERT A. WELCH, MILTON G. MUTCHNICK,etc Published: 1 April 1987
郯城县| 龙里县| 武安市| 应城市| 泸水县| 邢台市| 怀安县| 德令哈市| 浠水县| 微博| 错那县| 汕尾市| 海淀区| 大冶市| 青神县| 德保县| 崇文区| 枣强县| 杭州市| 江油市| 仲巴县| 绥棱县| 贵州省| 西宁市| 嘉荫县| 永修县| 望江县| 乐亭县| 平安县| 中山市| 商都县| 白沙| 永寿县| 宜君县| 洛川县| 甘洛县| 垫江县| 巩留县| 蒙山县| 绥德县| 深州市|