N-P-TOSYLGLYCINE
- CAS No.
- 1080-44-0
- Chemical Name:
- N-P-TOSYLGLYCINE
- Synonyms
- Tos-Gly;TOS-GLY-OH;AURORA 963;N-TOS-Gly-OH;N-TOSYLGLYCINE;N-4-tosylglycine;N-P-TOSYLGLYCINE;N-p-Tosylglycine 97%;Tosylaminoacetic acid;OTAVA-BB BB0123400526
- CBNumber:
- CB0160643
- Molecular Formula:
- C9H11NO4S
- Molecular Weight:
- 229.25
- MDL Number:
- MFCD00045898
- MOL File:
- 1080-44-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-p-Tosylglycine 97% | 403458 | 1g | $31 |
| N-(p-Toluenesulfonyl)glycine >98.0%(HPLC)(T) | T2803 | 5g | $25 |
| N-(p-Toluenesulfonyl)glycine >98.0%(HPLC)(T) | T2803 | 25g | $70 |
| N-Tosylglycine | TRC-T631720-5G | 5g | $133 |
| N-Tosylglycine | TRC-T631720-250MG | 250mg | $65 |
| More product size | |||
| Melting point | 147-149 °C (lit.) |
|---|---|
| Boiling point | 430.0±55.0 °C(Predicted) |
| Density | 1.369±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.41±0.10(Predicted) |
| color | White |
| Major Application | peptide synthesis |
| InChI | 1S/C9H11NO4S/c1-7-2-4-8(5-3-7)15(13,14)10-6-9(11)12/h2-5,10H,6H2,1H3,(H,11,12) |
| InChIKey | VDKFCCZUCXYILI-UHFFFAOYSA-N |
| SMILES | Cc1ccc(cc1)S(=O)(=O)NCC(O)=O |
| CAS DataBase Reference | 1080-44-0(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2935.90.9500 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
N-P-TOSYLGLYCINE price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 403458 | N-p-Tosylglycine 97% | 1080-44-0 | 1g | $31 | 2023-06-20 | Buy |
| TCI Chemical | T2803 | N-(p-Toluenesulfonyl)glycine >98.0%(HPLC)(T) | 1080-44-0 | 5g | $25 | 2026-04-30 | Buy |
| TCI Chemical | T2803 | N-(p-Toluenesulfonyl)glycine >98.0%(HPLC)(T) | 1080-44-0 | 25g | $70 | 2026-04-30 | Buy |
| TRC | TRC-T631720-5G | N-Tosylglycine | 1080-44-0 | 5g | $133 | 2026-06-03 | Buy |
| TRC | TRC-T631720-250MG | N-Tosylglycine | 1080-44-0 | 250mg | $65 | 2026-06-03 | Buy |
N-P-TOSYLGLYCINE Chemical Properties,Uses,Production
Uses
N-Tosylglycine is a sulfonamide derivative used to synthesize metal complexes which potentially displays antibacterial activity.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
98-59-9
56-40-6
1080-44-0
Sodium carbonate (Na2CO3, 1.590 g, 15 mmol) was added to a solution of glycine (12.5 mmol) in water (15 mL) under continuous stirring until completely dissolved. The solution was cooled to -5°C and p-toluenesulfonyl chloride (15 mmol) was added in four batches over 1 hour. The reaction mixture was continued to be stirred at room temperature for about 4 h. The progress of the reaction was monitored using thin layer chromatography (TLC, unfolding agent was MeOH/DCM, 1:9). Upon completion of the reaction, the mixture was acidified with 20% aqueous hydrochloric acid to pH 2. The crystals were collected by diafiltration and washed with pH 2.2 buffer. The pure product 2-(4-methylphenylsulfonamido)acetic acid was dried in a desiccator. The yield was 99.34% (2.8410 g) and the melting point was 88.4-88.6°C. FTIR (KBr, cm-1 ): 3448 (O-H, COOH), 3277 (N-H), 2957 (C-H, aliphatic), 1730 (C=O), 1598, 1440 (C=C), 1354, 1321 (2S=O). 1185 (SO2-NH), 1111, 1094 (C-N, C-O).1H NMR (DMSO-d6) δ: 7.90-7.88 (t, J=6.3 Hz, 1H, NH), 7.65-7.63 (d, J=8.6 Hz, 2H, ArH), 7.34-7.33 (d, J=8.05 Hz, 2H, ArH ), 3.52-3.51 (d, J=5.7 Hz, 2H, CH2), 2.34 (s, 3H, CH3).13C NMR (DMSO-d6) δ: 170.7 (C=O), 143.1, 138.4, 130.0, 127.1 (aryl carbons), 44.3 (CH2), 21.5 (CH3).HRMS-ESI (m/z): 228.0412 ([M-H]-, calculated value: 228.0408).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 349 - 369
[2] PLoS ONE, 2018, vol. 13, # 1,
[3] Journal of the American Chemical Society, 2018, vol. 140, # 17, p. 5834 - 5841
[4] Journal of Molecular Catalysis A: Chemical, 2011, vol. 351, p. 41 - 45
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 31, p. 5618 - 5625
N-P-TOSYLGLYCINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20584 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
View Lastest Price from N-P-TOSYLGLYCINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | N-P-TOSYLGLYCINE
1080-44-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-02 | N-(p-Toluenesulfonyl)glycine
1080-44-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | N-P-TOSYLGLYCINE
1080-44-0
|
$100.00 | 1KG | 99% | Career Henan Chemical Co |
-
- N-P-TOSYLGLYCINE
1080-44-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- N-(p-Toluenesulfonyl)glycine
1080-44-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- N-P-TOSYLGLYCINE
1080-44-0
- $100.00
- 99%
- Career Henan Chemical Co
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