PRE-084 Hydrochloride
- CAS No.
- 138847-85-5
- Chemical Name:
- PRE-084 Hydrochloride
- Synonyms
- PRE-084;I-AMB;J000280;BIMI1803;J-000280;4-MeO-PBP;BIMI-1803;PRE-084HCl;ZXAFC000547;PRE-084 HCI
- CBNumber:
- CB0211068
- Molecular Formula:
- C19H27NO3
- Molecular Weight:
- 317.42
- MDL Number:
- MFCD00673883
- MOL File:
- 138847-85-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| PRE-084 solid | P2607 | 10MG | $188 |
| PRE-084 solid | P2607 | 50MG | $798 |
| PRE-084 hydrochloride Asreported | 256320 | 10mg | $403 |
| PRE-084 hydrochloride Asreported | 256320 | 50mg | $1018 |
| 2-Morpholinoethyl 1-phenylcyclohexanecarboxylate 97% | AA0019MH | 10mg | $66 |
| More product size | |||
| Boiling point | 446.6±40.0 °C(Predicted) |
|---|---|
| Density | 1.103±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | H2O: ≤24 mg/mL |
| pka | 5.99±0.10(Predicted) |
| form | solid |
| color | White |
| Water Solubility | H2O: ≤24mg/mL |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| InChI | 1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H |
| InChIKey | QUJWFJNHTBKCLU-UHFFFAOYSA-N |
| SMILES | Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3 |
| FDA UNII | 74BW8WG2MQ |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
PRE-084 Hydrochloride price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P2607 | PRE-084 solid | 138847-85-5 | 10MG | $188 | 2026-04-30 | Buy |
| Sigma-Aldrich | P2607 | PRE-084 solid | 138847-85-5 | 50MG | $798 | 2026-04-30 | Buy |
| Usbiological | 256320 | PRE-084 hydrochloride Asreported | 138847-85-5 | 10mg | $403 | 2026-06-03 | Buy |
| Usbiological | 256320 | PRE-084 hydrochloride Asreported | 138847-85-5 | 50mg | $1018 | 2026-06-03 | Buy |
| aablocks | AA0019MH | 2-Morpholinoethyl 1-phenylcyclohexanecarboxylate 97% | 138847-85-5 | 10mg | $66 | 2026-05-28 | Buy |
PRE-084 Hydrochloride Chemical Properties,Uses,Production
Description
PRE084 (138847-85-8) is an agonist of the σ receptor with selectivity for the σ1 subtype(IC50’s: σ1 = 2.2nM, σ2 = 13091nM).1PRE-084 has demonstrated neuroprotective/restorative effects in brain injury2,3and neurodegenerative conditions4-7.
Definition
ChEBI: 1-phenyl-1-cyclohexanecarboxylic acid 2-(4-morpholinyl)ethyl ester is a member of morpholines.
Biological Activity
High affinity, selective σ 1 agonist (K i values are 2.2 and 13091 nM for σ 1 and σ 2 receptors respectively). Selective over PCP receptors (IC 50 > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo .
Biochem/physiol Actions
PRE-084 is a potent and highly selective σ1 opioid receptor agonist. It offers neuroprotection upon embolic stroke.
storage
Store at RT
References
[1] T P SU. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand.[J]. Journal of Pharmacology and Experimental Therapeutics, 1991, 259 2: 543-550.
[2] E. GRIESMAIER . Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice[J]. Experimental Neurology, 2012, 237 2: Pages 388-395. DOI:10.1016/j.expneurol.2012.06.030
[3] HUI DONG. Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury.[J]. Cellular and Molecular Neurobiology, 2016, 36 5: 639-645. DOI:10.1007/s10571-015-0244-0
[4] M.-S. GUZMáN-LENIS C. C X Navarro. Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons[J]. Neuroscience, 2009, 162 1: Pages 31-38. DOI:10.1016/j.neuroscience.2009.03.067
[5] A HYRSKYLUOTO. Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway[J]. Cell Death & Disease, 2013, 4 5: e646-e646. DOI:10.1038/cddis.2013.170
[6] VERONICA FRANCARDO. Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism.[J]. Brain, 2014, 137 Pt 7: 1998-2014. DOI:10.1093/brain/awu107
[7] RENZO MANCUSO . Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice[J]. Neurotherapeutics, 2012, 9 4: Pages 814-826. DOI:10.1007/s13311-012-0140-y
PRE-084 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9948 | 58 |
138847-85-5(PRE-084 Hydrochloride)Related Search:
1of4
