3-BROMO-2,4-DIMETHYLPYRIDINE
- CAS No.
- 27063-93-0
- Chemical Name:
- 3-BROMO-2,4-DIMETHYLPYRIDINE
- Synonyms
- 3-BroMo-2,4-lutidine;3-BROMO-2,4-DIMETHYLPYRIDINE;3-Bromo-2,4-Dimethylpiperidine;PYRIDINE, 3-BROMO-2,4-DIMETHYL
- CBNumber:
- CB02451679
- Molecular Formula:
- C7H8BrN
- Molecular Weight:
- 186.05
- MDL Number:
- MFCD09842453
- MOL File:
- 27063-93-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Bromo-2,4-dimethylpyridine 96% | OR938365 | 100mg | $43 |
| 3-Bromo-2,4-dimethylpyridine 96% | OR938365 | 250mg | $51 |
| 3-Bromo-2,4-dimethylpyridine 96% | OR938365 | 1g | $175 |
| 3-Bromo-2,4-dimethylpyridine 96% | OR938365 | 5g | $755 |
| 3-Bromo-2,4-dimethylpyridine 96% | OR938365 | 100mg | $43 |
| More product size | |||
| Boiling point | 28-29 °C(Press: 40 Torr) |
|---|---|
| Density | 1.415±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 4.25±0.18(Predicted) |
| Appearance | Off-white to light brown Solid-Liquid Mixture |
| CAS DataBase Reference | 27063-93-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3-BROMO-2,4-DIMETHYLPYRIDINE price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR938365 | 3-Bromo-2,4-dimethylpyridine 96% | 27063-93-0 | 100mg | $43 | 2026-06-04 | Buy |
| Apolloscientific | OR938365 | 3-Bromo-2,4-dimethylpyridine 96% | 27063-93-0 | 250mg | $51 | 2026-06-04 | Buy |
| Apolloscientific | OR938365 | 3-Bromo-2,4-dimethylpyridine 96% | 27063-93-0 | 1g | $175 | 2026-06-04 | Buy |
| Apolloscientific | OR938365 | 3-Bromo-2,4-dimethylpyridine 96% | 27063-93-0 | 5g | $755 | 2026-06-04 | Buy |
| Apolloscientific | OR938365 | 3-Bromo-2,4-dimethylpyridine 96% | 27063-93-0 | 100mg | $43 | 2026-06-04 | Buy |
3-BROMO-2,4-DIMETHYLPYRIDINE Chemical Properties,Uses,Production
Application
3-Bromo-2,4-dimethylpiperidine is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.
Synthesis
108-47-4
27063-92-9
29976-20-3
27063-93-0
Under stirring, 2,4-dimethylpyridine (5.39 mL, 46.7 mmol, 1 equiv.) was dissolved in bromide (50 mL) containing 20% free SO3, keeping the reaction temperature at 0 °C. An efficient reflux condenser was installed and the reaction mixture was heated to 165 °C in an oil bath. Bromine (4.30 mL, 83.4 mmol, 0.9 eq.) was added slowly in 0.5 mL portions over a period of 5 hours and stirring was continued at 155-175 °C for 20 hours. After completion of the reaction, the solution was cooled to room temperature, poured onto crushed ice (200 g) and stirred for 1 hour. The resulting orange solution was neutralized by careful addition of solid Na2CO3, diluted with water and extracted with EtOAc (2 x 250 mL). The organic layers were combined, dried with Na2SO4 and concentrated in vacuum. The crude product was purified by automated fast column chromatography (Biotage KP-Sil.TM.SNAP 340g column, 0-15% EtOAc/hexane) and dried under vacuum to give three bromo products: 3,5-dibromo-2,4-dimethylpyridine (8), 5-bromo-2,4-dimethylpyridine (9) and 3-bromo-2,4-dimethylpyridine (10). 3,5-Dibromo-2,4-dimethylpyridine (8) is a white solid (1.48 g, 12%) with a melting point of 28-30 °C; 1H NMR (400 MHz, CDCl3) δ 2.54 (s, 3H, CH3), 2.61 (s, 3H, CH3), 8.41 (s, 1H, pyHortho); 13C NMR (100 MHz, CDCl3) δ 23.8 (CH3), 25.7 (CH3), 120.3 (ArC), 124.4 (ArC), 146.4 (ArC), 148.5 (ArCH), 156.5 (ArC); IR νmax (film)/cm1 3045, 2998, 2956, 2921, 1558, 1433, 1376, 1349, 1232, 1376, 1349, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232 1376, 1349, 1232, 1049, 993, 928, 783; HRMS (ESI+) m/z calcd for C7H8Br2N [M+H]+ 263.9018, found 263.9027. 5-Bromo-2,4-dimethylpyridine (9) was a colorless oil (1.89 g, 22%); 1H NMR (400 MHz, CDCl3) δ 2.32 (s, 3H, CH3), 2.44 (s, 3H, CH3), 7.00 (s, 1H, pyHortho), 8.47 (s, 1H, pyHmeta); 13C NMR ( 100 MHz, CDCl3) δ 22.1 (CH3), 23.6 (CH3), 120.4 (ArC), 125.5 (ArCH), 146.7 (ArC), 150.5 (ArCH), 157.0 (ArC); IR νmax (film)/cm1 2985, 2957, 2924, 2854, 1592, 1461, 1377 1592, 1461, 1377, 1353, 1289, 1177, 1032; HRMS (ESI+) m/z calcd for C7H9BrN [M+H]+ 185.9913, found 185.9918. 3-Bromo-2,4-dimethylpyridine (10) was a colorless oil (3.04 g, 35%); 1H NMR (400 MHz, CDCl3) δ 2.33 (s, 3H, CH3), 2.61 (s, 3H, CH3), 6.91 (d, J = 5.0 Hz, 1H, pyHmeta), 8.18 (d, J = 5.0 Hz, 1H, 2995, 2958, 2922, 1585, 1437, 1389, 1123, 1024, 916, 825; HRMS (ESI+) m/z calcd for C7H9BrN [M+H]+ 185.9913, found 185.9917.
References
[1] Zeitschrift fuer Chemie (Stuttgart, Germany), 1988, vol. 28, # 2, p. 59 - 60
[2] Patent: WO2010/43866, 2010, A2. Location in patent: Page/Page column 48; 87-88
[3] Organic and Biomolecular Chemistry, 2011, vol. 9, # 1, p. 127 - 135
3-BROMO-2,4-DIMETHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 |
View Lastest Price from 3-BROMO-2,4-DIMETHYLPYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-04 | 3-BROMO-2,4-DIMETHYLPYRIDINE
27063-93-0
|
$6.00 | 2KG | 98% | 1KG,50KG,100KG | Career Henan Chemical Co |
-
- 3-BROMO-2,4-DIMETHYLPYRIDINE
27063-93-0
- $6.00
- 98%
- Career Henan Chemical Co
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