1-BOC-4-BROMO-1H-INDAZOLE
- CAS No.
- 926922-37-4
- Chemical Name:
- 1-BOC-4-BROMO-1H-INDAZOLE
- Synonyms
- tert-butyl 4-bromo-1H-indazole-1-carboxylate;1-BOC-4-BROMO-1H-INDAZOLE;4-Bromoindazole-1-carboxylic;4-Bromo-1H-indazole, N1-BOC protected;tert-butyl 4-bromoindazole-1-carboxylate;4-Bromoindazole-1-carboxylic acid tert-butyl ester;1,1-Dimethylethyl 4-bromo-1H-indazole-1-carboxylate;4-Bromo-1H-indazole-1-carboxylic acid tert-butyl ester;1H-INDAZOLE-1-CARBOXYLIC ACID,4-BROMO-,1,1-DIMETHYLETHYL ESTER
- CBNumber:
- CB02456063
- Molecular Formula:
- C12H13BrN2O2
- Molecular Weight:
- 297.15
- MDL Number:
- MFCD11110271
- MOL File:
- 926922-37-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Boc-4-bromo-1H-indazole Asreported | 266168 | 50mg | $343 |
| 1-Boc-4-bromo-1H-indazole Asreported | 266168 | 100mg | $472 |
| 1-Boc-4-bromo-1H-indazole Asreported | 266168 | 250mg | $569 |
| 1-Boc-4-bromo-1H-indazole Asreported | 266168 | 500mg | $751 |
| 1-Boc-4-bromo-1H-indazole Asreported | 266168 | 1g | $1117 |
| More product size | |||
| Boiling point | 377.4±34.0 °C(Predicted) |
|---|---|
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -2.73±0.30(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C12H13BrN2O2/c1-12(2,3)17-11(16)15-10-6-4-5-9(13)8(10)7-14-15/h4-7H,1-3H3 |
| InChIKey | OFVPGIHEBLOESV-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)C2=C(C(Br)=CC=C2)C=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| HS Code | 2933998090 |
1-BOC-4-BROMO-1H-INDAZOLE price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 266168 | 1-Boc-4-bromo-1H-indazole Asreported | 926922-37-4 | 50mg | $343 | 2026-06-03 | Buy |
| Usbiological | 266168 | 1-Boc-4-bromo-1H-indazole Asreported | 926922-37-4 | 100mg | $472 | 2026-06-03 | Buy |
| Usbiological | 266168 | 1-Boc-4-bromo-1H-indazole Asreported | 926922-37-4 | 250mg | $569 | 2026-06-03 | Buy |
| Usbiological | 266168 | 1-Boc-4-bromo-1H-indazole Asreported | 926922-37-4 | 500mg | $751 | 2026-06-03 | Buy |
| Usbiological | 266168 | 1-Boc-4-bromo-1H-indazole Asreported | 926922-37-4 | 1g | $1117 | 2026-06-03 | Buy |
1-BOC-4-BROMO-1H-INDAZOLE Chemical Properties,Uses,Production
Synthesis
24424-99-5
186407-74-9
926922-37-4
At room temperature, 4-bromo-1H-indazole (1.0 g, 5.07 mmol) was dissolved in dichloromethane (DCM, 20 mL), followed by sequential addition of triethylamine (TEA, 0.85 mL, 6.1 mmol) and 4-dimethylaminopyridine (DMAP, 0.062 g, 0.50 mmol). Di-tert-butyl dicarbonate (Boc anhydride, 1.28 mL, 5.58 mmol) was added slowly and dropwise to the reaction mixture under continuous stirring. The reaction mixture was continued to be stirred at room temperature for 2.5 hours. Upon completion of the reaction, the mixture was poured into water (30 mL) and extracted with dichloromethane (2 x 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: hexane solution of 15-20% ethyl acetate) to afford the target compound tert-butyl 4-bromo-1H-indazole-1-carboxylate (1.5 g, 5.06 mmol). The product was analyzed by LCMS (Method C) showing a retention time of 2.601 min and a mass spectrum (MS: ES+) m/z of 297.19; NMR hydrogen spectrum (400 MHz, DMSO-d6) δ ppm: 8.20 (s, 1H), 8.15 (d, J = 8.0 Hz, 1H), 7.47 (dd, J = 0.8 Hz, 7.6 Hz. 1H), 7.37-7.41 (m, 1H), 1.74 (s, 9H).
References
[1] Patent: WO2007/21937, 2007, A2. Location in patent: Page/Page column 42
[2] Patent: WO2017/109488, 2017, A1. Location in patent: Page/Page column 43
1-BOC-4-BROMO-1H-INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Hangzhou Dingxin Biotechnology Co., Ltd. | 0571-88194596 15558156576 | sales@disynchem.com | China | 94 | 55 |
