3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
![3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Structure](CAS/GIF/4922-68-3.gif)
- CAS No.
- 4922-68-3
- Chemical Name:
- 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
- Synonyms
- Ponatinib Impurity 9;s-Triazolo[4,3-a]pyridine, 3-bromo-;3-bromo-[1,2,4]triazolo[4,3-a]pyridine;1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO-
- CBNumber:
- CB02456245
- Molecular Formula:
- C6H4BrN3
- Molecular Weight:
- 198.02
- MDL Number:
- MFCD11111699
- MOL File:
- 4922-68-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 264574 | 50mg | $368 |
| 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 264574 | 100mg | $496 |
| 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 264574 | 250mg | $672 |
| 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 264574 | 500mg | $885 |
| 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 264574 | 1g | $1168 |
| Melting point | 165-167 °C |
|---|---|
| Density | 1.89±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 0.97±0.50(Predicted) |
| Appearance | Light brown to brown Solid |
| InChI | InChI=1S/C6H4BrN3/c7-6-9-8-5-3-1-2-4-10(5)6/h1-4H |
| InChIKey | BOKHADJFZUWNSH-UHFFFAOYSA-N |
| SMILES | C12=NN=C(Br)N1C=CC=C2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H310-H302-H315-H319 |
| Precautionary statements | P501-P270-P262-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P312+P330-P302+P352+P310-P405 |
| HS Code | 2933998090 |
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 264574 | 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 4922-68-3 | 50mg | $368 | 2026-06-03 | Buy |
| Usbiological | 264574 | 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 4922-68-3 | 100mg | $496 | 2026-06-03 | Buy |
| Usbiological | 264574 | 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 4922-68-3 | 250mg | $672 | 2026-06-03 | Buy |
| Usbiological | 264574 | 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 4922-68-3 | 500mg | $885 | 2026-06-03 | Buy |
| Usbiological | 264574 | 3-Bromo[1,2,4]triazolo[4,3-a]pyridine Asreported | 4922-68-3 | 1g | $1168 | 2026-06-03 | Buy |
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Chemical Properties,Uses,Production
Uses
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine is an intermediate used to prepare bi-aryl amines as mGluR5 modulators for treating gastrointestinal, urinary tract, and nervous system disorders.
Synthesis
![1,7,8-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene](/CAS/GIF/274-80-6.gif)
274-80-6
![3-Bromo-[1,2,4]triazolo[4,3-a]pyridine](/CAS/GIF/4922-68-3.gif)
4922-68-3
General procedure for the synthesis of 3-bromo-[1,2,4]triazolo[4,3-a]pyridine from [1,2,4]triazolo[4,3-a]pyridine: [1,2,4]triazolo[4,3-a]pyridine (1.26 g) and N-bromosuccinimide (NBS, 1.98 g) were dissolved in chloroform, and the reaction was carried out at reflux for 5 h followed by a 14-h stand at room temperature. Upon completion of the reaction, saturated aqueous potassium carbonate (200 mL) and potassium hydroxide (20 g) were added to the mixture, and the organic layer was separated after sufficient shaking. The aqueous layer was extracted twice with dichloromethane (DCM). All organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) followed by evaporation of the solvent under vacuum to afford the target product 3-bromo-[1,2,4]triazolo[4,3-a]pyridine in 60% yield.
References
[1] Patent: EP2743266, 2014, A2. Location in patent: Page/Page column
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CHANGZHOU HARVECHEM LTD | +86-0519-88784888 13912348604 | inquiry@harvechem.com | China | 311 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 4001 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29793 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1299 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19891622721 | gao490372054@gamil.com | China | 1249 | 58 |
View Lastest Price from 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![3-Bromo-[1,2,4]triazolo[4,3-a]pyridine pictures](/ProductImageEN1/2024-08/Small/24f68623-f41b-4754-bfde-0e925ec73eb7.png) |
2025-12-12 | 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
4922-68-3
|
$1.00-2.10 | 1KG | 99% | 20000KG | Shaanxi Dideu Medichem Co. Ltd | |
![1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO- pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/7e3c2ea3-8742-4175-af0b-f70a7696c321.png) |
2020-01-05 | 1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO-
4922-68-3
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
4922-68-3
- $1.00-2.10
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO-
4922-68-3
- $9.80
- ≥99%
- Career Henan Chemical Co
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