2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide
- CAS No.
- 280773-17-3
- Chemical Name:
- 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide
- Synonyms
- N-(5-chloro-pyridin-2-yl)-5-Methoxy-2-aMinobenzaMide;N-(5-chloropyridin-2-yl)-2-yl)-5-methoxy-2-aminobenzamide;-5-methoxybenzamide;Betrixaban Impurity 4;Betrixaban 2-Amino Impurity;2-Amino-N-(5-chloropyridin-2-yl);2-Amino-N-(5-chloro-2-pyridyl)-5-methoxybenzamide;2-AMino-N-(5-chloro-2-pyridinyl)-5-MethoxybenzaMide;2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide;Benzamide, 2-amino-N-(5-chloro-2-pyridinyl)-5-methoxy-
- CBNumber:
- CB02616913
- Molecular Formula:
- C13H12ClN3O2
- Molecular Weight:
- 277.71
- MDL Number:
- MFCD12841614
- MOL File:
- 280773-17-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | A56756 | 250mg | $68 |
| 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | A56756 | 1g | $76 |
| 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | A56756 | 5g | $78 |
| 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | A56756 | 10g | $80 |
| 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | A56756 | 25g | $170 |
| More product size | |||
| Boiling point | 396.9±42.0 °C(Predicted) |
|---|---|
| Density | 1.390 |
| storage temp. | 2-8°C(protect from light) |
| pka | 11.19±0.70(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C13H12ClN3O2/c1-19-9-3-4-11(15)10(6-9)13(18)17-12-5-2-8(14)7-16-12/h2-7H,15H2,1H3,(H,16,17,18) |
| InChIKey | GCCIHZVIPXGAPR-UHFFFAOYSA-N |
| SMILES | C(NC1=NC=C(Cl)C=C1)(=O)C1=CC(OC)=CC=C1N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H371 |
| Precautionary statements | P260-P264-P270-P309+P311-P405-P501 |
| REACH Registrations | Active |
2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | A56756 | 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | 280773-17-3 | 250mg | $68 | 2026-05-06 | Buy |
| Synthonix | A56756 | 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | 280773-17-3 | 1g | $76 | 2026-05-06 | Buy |
| Synthonix | A56756 | 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | 280773-17-3 | 5g | $78 | 2026-05-06 | Buy |
| Synthonix | A56756 | 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | 280773-17-3 | 10g | $80 | 2026-05-06 | Buy |
| Synthonix | A56756 | 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 98% | 280773-17-3 | 25g | $170 | 2026-05-06 | Buy |
2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide Chemical Properties,Uses,Production
Synthesis
280773-16-2
280773-17-3
General procedure for the synthesis of N-(5-chloro-2-pyridinyl)-5-methoxy-2-nitrobenzamide from N-(5-chloro-2-pyridinyl)-5-methoxy-2-aminobenzamide: N-(5-chloro-2-pyridinyl)-5-methoxy-2-nitrobenzamide (30 g, 1.0 eq.) was suspended in methanol (300 ml, 10 v/v) and added with ferric chloride (1.58 g, 0.1 eq.) and heated to reflux. Subsequently, hydrazine hydrate (80%, 24.4 g, 4.0 eq.) was slowly added dropwise and the reaction was kept under reflux conditions for 6 hours. The reaction was monitored by HPLC until the peak area of the feedstock was less than 0.3%. After completion of the reaction, most of the solvent was removed by concentration under reduced pressure and cooled to room temperature. Ethyl acetate was added and stirred for 1 hour. The organic phase was washed sequentially with water and saturated brine, separated and dried over anhydrous sodium sulfate. Finally, concentrated to dryness under reduced pressure to obtain a light yellow solid product. The purity of the product was greater than 98% and the yield was 93%.
References
[1] Patent: CN108586325, 2018, A. Location in patent: Paragraph 0021; 0030-0036
[2] Patent: US2007/112039, 2007, A1. Location in patent: Page/Page column 10-11
[3] Patent: WO2008/57972, 2008, A1. Location in patent: Page/Page column 32-33; 45-46
[4] Patent: US2008/153876, 2008, A1. Location in patent: Page/Page column 24-25
[5] Patent: WO2011/84519, 2011, A1. Location in patent: Page/Page column 38-39
2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1796 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3004 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14320 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 951 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15058 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
View Lastest Price from 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide
280773-17-3
|
$100.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
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- 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide
280773-17-3
- $100.00
- 98%
- Career Henan Chemical Co
