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DL-4-Chlorophenylalanine

DL-4-Chlorophenylalanine structure

CAS No.: 7424-00-2

Chemical Name:: DL-4-Chlorophenylalanine

Synonyms: PCP;P-CHLOROPHENYLALANINE;4-CHLORO-DL-PHENYLALANINE;Fenclonine;2-amino-3-(4-chlorophenyl)propanoic acid;H-DL-PHE(4-CL)-OH;2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID;OI13;c-pal;PCOLC

CBNumber:: CB0261841

Molecular Formula:: C9H10ClNO2

Molecular Weight:: 199.63

MDL Number:: MFCD00002601

MOL File:: 7424-00-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:33:43

Product description	Number	Pack Size	Price
4-Chloro-DL-phenylalanine	C6506	5g	$163
4-Chloro-DL-phenylalanine	C6506	25g	$603
4-Chloro-DL-phenylalanine >98.0%(T)	C0253	1g	$22
4-Chloro-DL-phenylalanine >98.0%(T)	C0253	25g	$290
p-chloro Phenylalanine ≥98%	26168	5g	$44
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DL-4-Chlorophenylalanine Properties

Melting point	>240 °C (dec.)(lit.)
Boiling point	339.5±32.0 °C(Predicted)
Density	1.2409 (rough estimate)
refractive index	1.5790 (estimate)
storage temp.	room temp
solubility	Aqueous Acid (Slightly), Methanol (Slightly)
pka	pK1: 2.08(+1);pK2: 8.96(0) (25°C)
form	Powder
color	White to almost white
Water Solubility	slightly soluble
BRN	2805758
InChI	1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChIKey	NIGWMJHCCYYCSF-UHFFFAOYSA-N
SMILES	NC(Cc1ccc(Cl)cc1)C(O)=O
CAS DataBase Reference	7424-00-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	R5J7E3L9SP
EPA Substance Registry System	4-Chlorophenylalanine (7424-00-2)
UNSPSC Code	12352209
NACRES	NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H317

Precautionary statements

P280-P301+P310+P330-P302+P352

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

25-43

Safety Statements

36/37-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

AY4390010

TSCA

TSCA listed

HS Code

29224985

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Skin Sens. 1

Hazardous Substances Data

7424-00-2(Hazardous Substances Data)

NFPA 704

	0
1		0

DL-4-Chlorophenylalanine price More Price(80)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C6506	4-Chloro-DL-phenylalanine	7424-00-2	5g	$163	2026-04-30	Buy
Sigma-Aldrich	C6506	4-Chloro-DL-phenylalanine	7424-00-2	25g	$603	2026-04-30	Buy
TCI Chemical	C0253	4-Chloro-DL-phenylalanine >98.0%(T)	7424-00-2	1g	$22	2026-04-30	Buy
TCI Chemical	C0253	4-Chloro-DL-phenylalanine >98.0%(T)	7424-00-2	25g	$290	2026-04-30	Buy
Cayman Chemical	26168	p-chloro Phenylalanine ≥98%	7424-00-2	5g	$44	2026-04-30	Buy

Product number	Packaging	Price	Buy
C6506	5g	$163	Buy
C6506	25g	$603	Buy
C0253	1g	$22	Buy
C0253	25g	$290	Buy
26168	5g	$44	Buy

DL-4-Chlorophenylalanine Chemical Properties,Uses,Production

Chemical Properties

Crystalline

Uses

4-Chloro-DL-phenylalanine has been used:

as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras⁺ male zebrafish
to induce insomnia in rat models
used to treat embryos to examine its effect on serotonin
for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
to feed flies to explore serotonin effect

Uses

4-Chloro-DL-phenylalanine is an irreversible tryptophan hydroxylase inhibitor that depletes serotonin in the brain.

Uses

An irreversible tryptophan hydroxylase inhibitor.

Definition

ChEBI: 2-amino-3-(4-chlorophenyl)propanoic acid is a phenylalanine derivative.

Biological Activity

4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.

Biochem/physiol Actions

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.

Safety Profile

An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and Cl-.

in vivo

4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway.

storage

Room temperature

DL-4-Chlorophenylalanine synthesis

Synthesis of DL-4-Chlorophenylalanine from 4-Chlorobenzyl chloride

DL-4-Chlorophenylalanine Preparation Products And Raw materials

Raw materials

Glycine, N-[(4-chlorophenyl)methylene]-, ethyl ester Propanedioic acid,2-(acetylamino)-2-[(4-chlorophenyl)methyl]-, 1,3-diethyl ester L-4-Chlorophenylalanine DL-4-CHLOROPHENYLALANINE ETHYL ESTER HYDROCHLORIDE 4-Chlorocinnamic acid

4-Chlorobenzyl chloride 4-Chlorobenzyl bromide 4-Chlorobenzaldehyde

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Preparation Products

4-Chlorophenethylamine

DL-4-Chlorophenylalanine Suppliers

Global( 301)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58
GL Biochem(Binhai) Ltd.	+86-021-61263370 +8615301650015	wuqiuyan@glschina.com	China	2975	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29094	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
GL Biochem (Shanghai) Ltd.	58
GL Biochem(Binhai) Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
BOC Sciences	58

View Lastest Price from DL-4-Chlorophenylalanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	Fenclonine 7424-00-2	$42.00		99.90%	10g	TargetMol Chemicals Inc.
2026-04-22	Fenclonine 7424-00-2	$42.00		99.90%	10g	TargetMol Chemicals Inc.
2021-08-12	DL-4-Chlorophenylalanine 7424-00-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Fenclonine
7424-00-2
$42.00
99.90%
TargetMol Chemicals Inc.

Fenclonine
7424-00-2
$42.00
99.90%
TargetMol Chemicals Inc.

DL-4-Chlorophenylalanine
7424-00-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

DL-4-Chlorophenylalanine Spectrum

DL-4-Chlorophenylalanine(7424-00-2)MS DL-4-Chlorophenylalanine(7424-00-2)¹HNMR DL-4-Chlorophenylalanine(7424-00-2)IR1 DL-4-Chlorophenylalanine(7424-00-2)Raman

7424-00-2(DL-4-Chlorophenylalanine)Related Search:

DL-O-CHLOROPHENYLALANINE DL-P-CHLOROPHENYLALANINE METHYL ESTER*HY,DL-4-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE,DL-P-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE DL-PENICILLAMINE 2-FLUORO-DL-PHENYLALANINE 4-Iodo-DL-phenylalanine

4-BROMO-DL-PHENYLALANINE 3-(3-Hydroxyphenyl)-DL-alanine DL-4-Cyanophenylalanine 2-AMINO-3-(3-METHOXY-PHENYL)-PROPIONIC ACID 2-Bromo-DL-Phenylalanine

DL-3-(4-Fluorophenyl)alanine L-4-Chlorophenylalanine DL-4-CHLOROPHENYLALANINE ETHYL ESTER HYDROCHLORIDE,DL-P-CHLOROPHENYLALANINE ETHYL ESTER HYDROCHLORIDE BOC-DL-4-CHLOROPHENYLALANINE FMOC-DL-2-CHLOROPHENYLALANINE

FMOC-DL-3-CHLOROPHENYLALANINE FMOC-DL-4-CHLOROPHENYLALANINE CBZ-DL-4-CHLOROPHENYLALANINE

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(±)-3-(4-Chlorophenyl)-2-aminopropanoic acid NSC-77370 DL-4-Chloro-phe-OH DL-Phe(4-Cl)-OH 4-Chloro-DL-Phenylalanine H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA 4-Chloro-DL-phenylalanine, 98+% DL-4-Chlorophenylalanine, 98+%, 98+% DL-2-Amino-3-(4-chloro-phenyl)-propionic acid 4-Chloro-DL-phenylalanine (PCPA) Fenchlonine(PCPA) 4-CHLOROPHENYLALANINE DL-4-CHLOROPHENYLALANINE DL-P-CHLOROPHENYLALANINE fenclonin (RS)-2-Amino-3-(4-chlorophenyl)propionic acid 4-Chloro-DL-phenylalanine≥ 99% (HPLC) (+/-)-P-CHLOROPHENYLALANINE, (P-CPA) CAU SES DEPLETION OF S DL-P-CHLOROPHENYLALANINE CRYSTALLINE 4-Chloro-Dl-Phenylalanine,>99% 3-(4-CHLOROPHENYL)ALANINE,DL- DL-Phe(4-Cl)-OH 3-(4-Chlorophenyl)-DL-alanine DL-4-Chlorophenylalanine, 98+% PCP, PCPA (2R)-2-Azaniumyl-3-(4-chlorophenyl)propanoate Alanine, 3-(p-chlorophenyl)- 3-(p-chlorophenyl)-DL-alanine P-chloro benzoic acetate (+-)-p-chlorphenylalanine cp10,188 c-pal LABOTEST-BB LT00453604 H-P-CHLORO-DL-PHE-OH TIMTEC-BB SBB003551 P-CHLORO-DL-PHENYLALANINE fenchlonine (2S)-2-ammonio-3-(4-chlorophenyl)propanoate 4-Chloro-DL-phenylalanine > Chloro DL Phenylalanine, 4-chloro- -4-ChL DL-4-Chlorophenylalanine USP/EP/BP p-Chlorophenylalanin Fenclonine (PCPA 2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID 2-amino-3-(4-chlorophenyl)propanoic acid PCP P-CHLOROPHENYLALANINE 4-Chloro-DL-phenylalanine, ≥ 98.0% Contezolid Impurity 9 Fenclonine, 10 mM in DMSO 4-Chloro-DL-phenylalanine OI13 PCOLC C6506-5G 4-Chloro-DL-phenylalanine[C6506] 4-CHLORO-DL-PHENYLALANINE Fenclonine

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DL-4-Chlorophenylalanine

DL-4-Chlorophenylalanine Properties

SAFETY

Risk and Safety Statements

DL-4-Chlorophenylalanine price More Price(80)

DL-4-Chlorophenylalanine Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Uses

Definition

Biological Activity

Biochem/physiol Actions

Safety Profile

in vivo

storage

DL-4-Chlorophenylalanine synthesis

DL-4-Chlorophenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

DL-4-Chlorophenylalanine Suppliers

View Lastest Price from DL-4-Chlorophenylalanine manufacturers

DL-4-Chlorophenylalanine Spectrum

7424-00-2(DL-4-Chlorophenylalanine)Related Search: