N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE
![N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Structure](CAS/GIF/1083326-75-3.gif)
- CAS No.
- 1083326-75-3
- Chemical Name:
- N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE
- Synonyms
- 6-Methoxy-5-(methylsulfonamido)pyridine-3-boronic acid pinacol ester;N-(2-Methoxy-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)MethanesulfonaMide;N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE;Methanesulfonamide, N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-;N-[2-(Methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]methanesulfonamide
- CBNumber:
- CB02640677
- Molecular Formula:
- C13H21BN2O5S
- Molecular Weight:
- 328.19
- MDL Number:
- MFCD12964555
- MOL File:
- 1083326-75-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide | 185399 | 100.00mg | $83 |
| N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide | 185399 | 250.00mg | $145 |
| N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide | 185399 | 1.00g | $381 |
| N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide 95+% | M57221 | 100mg | $90 |
| N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide 95+% | M57221 | 250mg | $220 |
N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Properties
| Boiling point | 452.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 6.62±0.50(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C13H21BN2O5S/c1-12(2)13(3,4)21-14(20-12)9-7-10(16-22(6,17)18)11(19-5)15-8-9/h7-8,16H,1-6H3 |
| InChIKey | NLKPUGUGRJNIMU-UHFFFAOYSA-N |
| SMILES | CS(NC1=CC(B2OC(C)(C)C(C)(C)O2)=CN=C1OC)(=O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H225 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405 |
N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 185399 | N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide | 1083326-75-3 | 100.00mg | $83 | 2026-05-18 | Buy |
| Matrix Scientific | 185399 | N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide | 1083326-75-3 | 250.00mg | $145 | 2026-05-18 | Buy |
| Matrix Scientific | 185399 | N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide | 1083326-75-3 | 1.00g | $381 | 2026-05-18 | Buy |
| Synthonix | M57221 | N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide 95+% | 1083326-75-3 | 100mg | $90 | 2026-05-06 | Buy |
| Synthonix | M57221 | N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide 95+% | 1083326-75-3 | 250mg | $220 | 2026-05-06 | Buy |
N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Chemical Properties,Uses,Production
Synthesis
1083327-58-5
73183-34-3
![N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE](/CAS/GIF/1083326-75-3.gif)
1083326-75-3
GENERAL STEPS: N-(5-bromo-2-methoxypyridin-3-yl)methanesulfonamide (3.35 g, 11.9 mmol) and pinacol ester of bisboronic acid (4.24 g, 16.7 mmol) were suspended in toluene (100 mL), degassed and displaced three times with nitrogen. Tris(dibenzylideneacetone)dipalladium (616 mg, 0.595 mmol) and triphenylphosphine (243 mg, 0.892 mmol) were then added. The mixture was heated to 45 °C and stirred for 45 min, then potassium acetate (3.74 g, 23.8 mmol) was added. The reaction mixture was heated to reflux and stirring was continued for 3 hours. After completion of the reaction, it was cooled to room temperature, diluted with ethyl acetate (100 mL) and filtered through diatomaceous earth. The filtrate was washed sequentially with water (70 mL x 3) and saturated brine (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate, v/v=2/1) to afford N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methane sulfonamide as a white solid (2.90 g, 74%). Mass spectrum (ESI, cation mode) m/z: 328.9 [M + H]+; 1H NMR (600 MHz, CDCl3): δ 8.32 (d, J=1.4 Hz, 1H), 8.06 (d, J=1.3 Hz, 1H), 6.66 (br s, 1H), 4.05 (s, 3H), 3.02 (s, 3H), 1.33 (s. 12H).
References
[1] Organic Process Research and Development, 2018, vol. 22, # 3, p. 368 - 376
[2] Patent: US2014/134133, 2014, A1. Location in patent: Paragraph 0441
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 3, p. 637 - 646
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6087 - 6109
[5] European Journal of Medicinal Chemistry, 2018, vol. 146, p. 460 - 470
N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Preparation Products And Raw materials
N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Spectrum
1083326-75-3(N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE)Related Search:
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