SIRT2 Inhibitor II, AK-1
- CAS No.
- 330461-64-8
- Chemical Name:
- SIRT2 Inhibitor II, AK-1
- Synonyms
- CS-923;AK 1, >=98%;AK-1;AK1;AK 1;AK-1 >=98% (HPLC);AK-1, 10 mM in DMSO;AK-1, SIRT2 inhibitor;SIRT2 Inhibitor II, AK-1;inhibit,AK-1,AK 1,AK1,Inhibitor,Sirtuin;Benzamide, 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-;3-(azepane-1-sulfonyl)-N-(3-nitro-phenyl)-benzamide SIRT2 Inhibitor II, AK-1
- CBNumber:
- CB02684460
- Molecular Formula:
- C19H21N3O5S
- Molecular Weight:
- 403.45
- MDL Number:
- MOL File:
- 330461-64-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SIRT2 Inhibitor II, AK-1 The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications. | 566331 | 10 mg | $161 |
| AK-1 ≥90% | 21276 | 5mg | $63 |
| AK-1 ≥90% | 21276 | 10mg | $98 |
| AK-1 ≥90% | 21276 | 25mg | $229 |
| AK-1 | 21276 | 5mg | $57 |
| More product size | |||
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 10 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 0.3 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
| InChI | 1S/C19H21N3O5S/c23-19(20-16-8-6-9-17(14-16)22(24)25)15-7-5-10-18(13-15)28(26,27)21-11-3-1-2-4-12-21/h5-10,13-14H,1-4,11-12H2,(H,20,23) |
| InChIKey | HAYBKCHPEBZNGW-UHFFFAOYSA-N |
| SMILES | O=S(N1CCCCCC1)(C2=CC(C(NC3=CC=CC([N+]([O-])=O)=C3)=O)=CC=C2)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SIRT2 Inhibitor II, AK-1 price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 566331 | SIRT2 Inhibitor II, AK-1 The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications. | 330461-64-8 | 10 mg | $161 | 2026-04-30 | Buy |
| Cayman Chemical | 21276 | AK-1 ≥90% | 330461-64-8 | 5mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 21276 | AK-1 ≥90% | 330461-64-8 | 10mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 21276 | AK-1 ≥90% | 330461-64-8 | 25mg | $229 | 2026-04-30 | Buy |
| Cayman Chemical | 21276 | AK-1 | 330461-64-8 | 5mg | $57 | 2024-03-01 | Buy |
SIRT2 Inhibitor II, AK-1 Chemical Properties,Uses,Production
Description
AK-1 is a SIRT2 Inhibitor II that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.
Uses
AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.
IC 50
SIRT2: 12.5 μM (IC50)
References
[1] Ruth Luthi-Carter, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32. DOI:10.1073/pnas.1002924107
[2] Lee SD, et al. AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia. Cancer Lett. 2016 Apr 1;373(1):138-45. DOI:10.1016/j.canlet.2016.01.031
[3] Luthi-Carter R, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32.
[4] David M. Taylor, et al. A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase. ACS Chem Biol. 2011 Jun 17;6(6):540-6. DOI:10.1021/cb100376q
[5] Cheon MG, et al. AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. Cancer Lett. 2015 Jan 28;356(2 Pt B):637-45. DOI:10.1016/j.canlet.2014.10.012
SIRT2 Inhibitor II, AK-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1876 | 55 |
View Lastest Price from SIRT2 Inhibitor II, AK-1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | AK-1
330461-64-8
|
$32.00-117.00 | 98.32% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-22 | SIRT2 Inhibitor II, AK-1
330461-64-8
|
1KG | 95%-99% | 1kg; 5kg; 10kg | Career Henan Chemica Co |
-
- AK-1
330461-64-8
- $32.00-117.00
- 98.32%
- TargetMol Chemicals Inc.
-
- SIRT2 Inhibitor II, AK-1
330461-64-8
- $0.01
- 95%-99%
- Career Henan Chemica Co
