AMG 9810
- CAS No.
- 545395-94-6
- Chemical Name:
- AMG 9810
- Synonyms
- 9810;CS-2548;AMG 9810;AMG-9810 ，S6934;AMG 9810;AMG-9810;AMG9810, 10 mM in DMSO;AMG 9810 >=98% (HPLC), powder;(2E)-N-(2，3-Dihydro-1，4-benzodi;AMG 9810, TRPV1 receptor antagonist;3-[4-(TERT-BUTYL)PHENYL]-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ACRYLAMIDE
- CBNumber:
- CB0306302
- Molecular Formula:
- C21H23NO3
- Molecular Weight:
- 337.41
- MDL Number:
- MFCD00955103
- MOL File:
- 545395-94-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| AMG 9810 ≥98% (HPLC), powder | A2731 | 10mg | $250 |
| AMG 9810 ≥98% (HPLC), powder | A2731 | 50mg | $985 |
| AMG 9810 ≥98% | 14715 | 5mg | $63 |
| AMG 9810 ≥98% | 14715 | 10mg | $105 |
| AMG 9810 ≥98% | 14715 | 25mg | $242 |
| More product size | |||
| Boiling point | 512.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.175±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >5mg/mL |
| pka | 12.22±0.20(Predicted) |
| form | powder |
| color | white to beige |
| InChI | 1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+ |
| InChIKey | GZTFUVZVLYUPRG-IZZDOVSWSA-N |
| SMILES | CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1 |
| FDA UNII | 182HIJ2D7F |
| UNSPSC Code | 12352203 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H413 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 4 |
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| NFPA 704 |
|
AMG 9810 price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A2731 | AMG 9810 ≥98% (HPLC), powder | 545395-94-6 | 10mg | $250 | 2026-04-30 | Buy |
| Sigma-Aldrich | A2731 | AMG 9810 ≥98% (HPLC), powder | 545395-94-6 | 50mg | $985 | 2026-04-30 | Buy |
| Cayman Chemical | 14715 | AMG 9810 ≥98% | 545395-94-6 | 5mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 14715 | AMG 9810 ≥98% | 545395-94-6 | 10mg | $105 | 2026-04-30 | Buy |
| Cayman Chemical | 14715 | AMG 9810 ≥98% | 545395-94-6 | 25mg | $242 | 2026-04-30 | Buy |
AMG 9810 Chemical Properties,Uses,Production
In vivo
AMG9810 is effective at preventing capsaicin-induced eye wiping in a dose-dependent manner, and it reverses thermal and mechanical hyperalgesia in a model of inflammatory pain induced by intraplantar injection of complete Freund's adjuvant. At effective doses, AMG9810 does not show any significant effects on motor function. AMG9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain. AMG9810, promotes mouse skin tumor development. The topical application of AMG9810 results in a significant increase in the expression level of the epidermal growth factor receptor (EGFR) and its downstream Akt/mammalian target of rapamycin (mTOR)-signaling pathway.
Description
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-
Uses
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia.[Cayman Chemical]
Definition
ChEBI: 3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.
Biological Activity
AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC 50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.
Biochem/physiol Actions
AMG 9810is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties.
storage
+4°C (desiccate)
References
[1]. gavva nr, tamir r, qu y, et al. amg 9810 [(e)-3-(4-t-butylphenyl)-n-(2, 3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (trpv1) antagonist with antihyperalgesic properties. j pharmacol exp ther, 2005, 313(1):474-84.
AMG 9810 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
View Lastest Price from AMG 9810 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![(2E)-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-PROPENAMIDE pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/666cff23-51c7-49f5-a336-a34eda87aa4b.png) |
2020-01-14 | (2E)-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-PROPENAMIDE
545395-94-6
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- (2E)-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-PROPENAMIDE
545395-94-6
- $9.80
- ≥99%
- Career Henan Chemical Co
