Conivaptan impurity
- CAS No.
- 1129433-63-1
- Chemical Name:
- Conivaptan impurity
- Synonyms
- Conivaptan-d4;N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl-d4]-[1,1'-biphenyl]-2-carboxamide
- CBNumber:
- CB03144862
- Molecular Formula:
- C32H26N4O2
- Molecular Weight:
- 498.59
- MDL Number:
- MOL File:
- 1129433-63-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Conivaptan-d4 ≥99%deuteratedforms(d1-d4) | 26455 | 500μg | $214 |
| Conivaptan-d4 ≥99%deuteratedforms(d1-d4) | 26455 | 1mg | $406 |
| Conivaptan-d4 | 26455 | 500μg | $194 |
| Conivaptan-d4 | 26455 | 1mg | $369 |
| Conivaptan-d4 ≥99%deuteratedforms(d1-d4) | AA01EQAW | 1mg | $406 |
Conivaptan impurity price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26455 | Conivaptan-d4 ≥99%deuteratedforms(d1-d4) | 1129433-63-1 | 500μg | $214 | 2026-04-30 | Buy |
| Cayman Chemical | 26455 | Conivaptan-d4 ≥99%deuteratedforms(d1-d4) | 1129433-63-1 | 1mg | $406 | 2026-04-30 | Buy |
| Cayman Chemical | 26455 | Conivaptan-d4 | 1129433-63-1 | 500μg | $194 | 2024-03-01 | Buy |
| Cayman Chemical | 26455 | Conivaptan-d4 | 1129433-63-1 | 1mg | $369 | 2024-03-01 | Buy |
| aablocks | AA01EQAW | Conivaptan-d4 ≥99%deuteratedforms(d1-d4) | 1129433-63-1 | 1mg | $406 | 2026-05-30 | Buy |
Conivaptan impurity Chemical Properties,Uses,Production
Uses
Conivaptan-d4 is deuterium labeled Conivaptan-d4.
Biological Activity
Conivaptan-d4 is intended for use as an internal standard for the quantification of conivaptan by GC- or LC-MS. Conivaptan is an antagonist of the arginine vasopressin (AVP) receptors V1A and V2 (Kis = 0.48 and 3.04 nM for rat liver V1A and kidney V2, respectively).1 It also competitively inhibits oxytocin binding to rat uterine oxytocin receptors (Ki = 44 nM) but has no effect on AVP binding to anterior pituitary V1B receptors at concentrations up to 100 μM in a radioligand binding assay. Conivaptan suppresses AVP-induced increases in intracellular calcium in vascular smooth muscle cells (VSMCs) in vitro and the pressor response in pithed rats. Conivaptan (0.01-0.3 mg/kg, i.v.) increases urine output and decreases urine osmolality in dehydrated conscious rats in a dose-dependent manner. It also reduces brain edema and blood-brain barrier disruption in a mouse experimental stroke model.2
References
1.Tahara, A., Tomura, Y., Wada, K.-I., et al.Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivoJ. Pharmacol. Exp. Ther.282(1)301-308(1997) 2.Zeynalov, E., Jones, S.M., Seo, J.W., et al.Arginine-vasopressin receptor blocker conivaptan reduces brain edema and blood-brain barrier disruption after experimental stroke in micePLoS One10(8)e0136121(2015)
Conivaptan impurity Preparation Products And Raw materials
Raw materials
Preparation Products
Conivaptan impurity Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4724 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11972 | 58 |
| Hubei Moco Chemical Co., Ltd. | 18627753421; 18627756402 | 3001051413@qq.com | China | 20018 | 58 |
| BePure (Beijing) Biotechnology Co. | -- | 7993601name@qq.com | CHINA | 6620 | 58 |
| Cayman Chemical Company | -- | sales@caymanchem.com | China | 6838 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235 | chinasales04@tlcstandards.com.cn | China | 8291 | 58 |
| Guangzhou Qiansheng Biotechnology Co., Ltd. | -- | CHINA | 6411 | 58 |
