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ChemicalBook >> CAS DataBase List >>Boc-His(Trt)-OH

Boc-His(Trt)-OH

CAS No.
32926-43-5
Chemical Name:
Boc-His(Trt)-OH
Synonyms
BOC-HIS(TRT)-OH;Boc-His(trt);His(Trt)-OH;BOC-L-HIS(TRT)-OH;Boc-L-His(Trt);Impurity HA-1;N-Boc-His(Trt)-OH;(S)-L-Boc-his(trt)-oh;Boc-His(Trt)-OH, >=98%;BOC-N-IM-TRITYL-L-HISTIDINE
CBNumber:
CB0342634
Molecular Formula:
C30H31N3O4
Molecular Weight:
497.59
MDL Number:
MFCD00153307
MOL File:
32926-43-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:38:31
Product description Number Pack Size Price
Boc-His(Trt)-OH Novabiochem? 8.53034 25g $1470
Boc-His(Trt)-OH Novabiochem® 8.53034 100 g $5180
Boc-His(Trt)-OH ≥98.0% (TLC) 15449 1g $47
Boc-His(Trt)-OH Novabiochem® 8.53034 100 g $5180
Boc-His(Trt)-OH TRC-B656218-1G 1g $72
More product size

Boc-His(Trt)-OH Properties

Melting point ~130 °C (dec.)
alpha 12.5 º (C=1% IN MEOH)
Boiling point 667.5±55.0 °C(Predicted)
Density 1.16±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Sparingly)
pka 3.17±0.10(Predicted)
form Solid
color White to Off-White
optical activity [α]20/D +12.5±1.0°, c = 1% in methanol
BRN 732035
Major Application peptide synthesis
InChIKey OYXZPXVCRAAKCM-SANMLTNESA-N
SMILES C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OC(C)(C)C)=O
CAS DataBase Reference 32926-43-5(CAS DataBase Reference)
FDA UNII C9YH4KHR73
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
HS Code  29224999
Storage Class 11 - Combustible Solids

Boc-His(Trt)-OH price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.53034 Boc-His(Trt)-OH Novabiochem? 32926-43-5 25g $1470 2026-04-30 Buy
Sigma-Aldrich 8.53034 Boc-His(Trt)-OH Novabiochem® 32926-43-5 100 g $5180 2026-04-30 Buy
Sigma-Aldrich 15449 Boc-His(Trt)-OH ≥98.0% (TLC) 32926-43-5 1g $47 2026-04-30 Buy
Sigma-Aldrich 8.53034 Boc-His(Trt)-OH Novabiochem® 32926-43-5 100 g $5180 2026-03-19 Buy
TRC TRC-B656218-1G Boc-His(Trt)-OH 32926-43-5 1g $72 2026-06-03 Buy
Product number Packaging Price Buy
8.53034 25g $1470 Buy
8.53034 100 g $5180 Buy
15449 1g $47 Buy
8.53034 100 g $5180 Buy
TRC-B656218-1G 1g $72 Buy

Boc-His(Trt)-OH Chemical Properties,Uses,Production

Chemical Properties

White to off white powder

Uses

Boc-His(Trt)-OH is a histidine derivative. Its a protected histidine derivative for only the critical coupling step. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.

Uses

Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.

Application

N-Boc-N'-Trityl-L-histidine (Boc-His(Trt)-OH) can be used as an intermediate in biochemistry and medicinal chemistry and can be used in the synthesis of peptide drug molecules, vitamins, and molecules with specific biologically active functions. In organic synthesis transformation, the carboxyl group in N-Boc-N'-trityl-L-histidine can undergo corresponding condensation reactions with amine compounds to obtain the corresponding amide products; in addition, in dithionyl chloride Under the action of N-Boc-N'-trityl-L-histidine, intramolecular dehydration cyclization reaction can be performed to obtain cyclic amide derivatives.

Preparation

The benzyl 2-tert-butoxycarbonylamino-3-(1-trimethylimidazol-4-yl)propionate was dissolved in methanol (20 mL), and potassium hydroxide was added to the reaction system. The reaction system was stirred for 1 h after THF was added to the reaction system. The solvent is removed under vacuum depressurization, and the mixture is then extracted with water and Et2O. Separate the two phases and acidify the aqueous layer with dilute HCl, extract it with Et2O, combine all the ether organic layer and wash it with water and saline, dry the organic layer with anhydrous magnesium sulfate, filter to remove the solvent, and concentrate the filtrate under vacuum under reduced pressure to obtain Boc-His(Trt)-OH.

reaction suitability

Reaction type: Boc solid-phase peptide synthesis

Boc-His(Trt)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 278)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co.,Ltd. 		+86-0512-68071238 +86-13771819922 june@highfine.com China 491 58
Chengdu ZY Biochemical Technology Co., Ltd.
+86-86-2888626688 18328376625 xuehaiying@zybiochem.com China 177 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20120 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14025 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Accela ChemBio Inc. 		+1-858-6993322 +86-18019713315 info@accelachem.com United States 21193 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6366 58

View Lastest Price from Boc-His(Trt)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-L-His(trt)-OH pictures 2026-08-05 Boc-L-His(trt)-OH
32926-43-5
 1kg 98%;99% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Boc-His(Trt)-OH pictures 2026-07-09 Boc-His(Trt)-OH
32926-43-5
 $6.00-8.00 1kg 99% Henan Fengda Chemical Co., Ltd
N-Boc-N'-trityl-L-histidine pictures 2025-04-04 N-Boc-N'-trityl-L-histidine
32926-43-5
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

Boc-His(Trt)-OH Spectrum

(S)-2-(tert-butoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid N-Boc-His(Trt)-OH (S)-2-(Boc-aMino)-3-(1-trityl-4-iMidazolyl)propionic acid, 95% Boc-His(Trt)-OH >=98.0% (TLC) Boc-His(Trt)-OH, >=98% (S)-L-Boc-his(trt)-oh BOC-N-IM-TRITYL-L-HISTIDINE N-T-BUTOXYCARBONYL-N-TAU-TRITYL-L-HISTIDINE N-ALPHA-TERT-BUTYLOXYCARBONYL-N-IM-TERT-TRITYL-L-HISTIDINE N-ALPHA-T-BOC-N-IM-TRITYL-L-HISTIDINE N-ALPHA-BOC-N-(IM)-TRITYL-L-HISTIDINE N-ALPHA-T-BUTYLOXYCARBONYL-N-IM-T-TRITY-L-HISTIDINE L-HISTIDINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-1-(TRIPHENYLMETHYL)- Nα-Boc-Nim-trityl-L-histidine≥ 99.7% (HPLC, Chiral purity) N-Boc-N'-trityl-L-histidine (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid Nα-(tert-butyloxy)carbonyl-Nim-triphenylmethyl-L-histidine (Tert-Butoxy)Carbonyl His(Trt)-OH 2-((TERT-BUTOXYCARBONYL)AMINO)-3-(1-TRITYL-1H-IMIDAZOL-4-YL)PROPANOIC ACID N-Boc-N'-trityl-L-histidine USP/EP/BP Nα-Boc-Nim-trityl-L-histidine N-[(1,1-Dimethylethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(1-tritylimidazol-4-yl)propanoic acid BOC-HIS(TRT)-OH Nα-Boc-N(im)-trityl-L-histidine N-Boc N '- Triphenylmethyl L-histidine Na-(tert-butoxycarbonyl)-N-trityl-L-histidine N-Boc-N'-triphenylmethyl-L-histidine Impurity HA-1 N-Boc-N'-trityl-L-histidine, 98% Boc-L-His(Trt) Boc-His(trt) BOC-L-HIS(TRT)-OH His(Trt)-OH 32926-43-5 32925-43-5 32626-43-5 C30H31N3O4 Amino Acid Derivatives Histidine Peptide Synthesis Specialty Synthesis Boc-Amino Acids and Derivative Boc-Amino acid series
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