1-PYRENEBUTYRIC ACID
- CAS No.
- 3443-45-6
- Chemical Name:
- 1-PYRENEBUTYRIC ACID
- Synonyms
- PyBA;Pyrenebutyric acid;NSC 30833;1-pyrenebutyrate;Pyrenebutyric aci;Pyren-1-buttersure;1-PYRENEBUTYRIC ACID;pyrene-1-butyric acid;1-Pyrenylbutyric acid;1-PYRENEBUTANOIC ACID
- CBNumber:
- CB0402161
- Molecular Formula:
- C20H16O2
- Molecular Weight:
- 288.34
- MDL Number:
- MFCD00004141
- MOL File:
- 3443-45-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Pyrenebutyric acid 97% | 257354 | 1g | $110 |
| 1-Pyrenebutyric acid 97% | 257354 | 5g | $338 |
| 4-(1-Pyrenyl)-butyric acid for synthesis | 8.41269 | 1g | $105 |
| 1-Pyrenebutyric Acid >98.0%(GC)(T) | P1213 | 1g | $75 |
| 1-Pyrenebutyric Acid >98.0%(GC)(T) | P1213 | 5g | $225 |
| More product size | |||
| Melting point | 184-186 °C (lit.) |
|---|---|
| Boiling point | 370.57°C (rough estimate) |
| Density | 1.1742 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Crystalline Powder |
| pka | 4.76±0.10(Predicted) |
| color | Pale yellow or yellow-beige |
| Appearance | off white solid |
| Water Solubility | Partially soluble in water. |
| BRN | 2140554 |
| InChI | InChI=1S/C20H16O2/c21-18(22)6-2-3-13-7-8-16-10-9-14-4-1-5-15-11-12-17(13)20(16)19(14)15/h1,4-5,7-12H,2-3,6H2,(H,21,22) |
| InChIKey | QXYRRCOJHNZVDJ-UHFFFAOYSA-N |
| SMILES | C1(CCCC(O)=O)=C2C3=C4C(C=C2)=CC=CC4=CC=C3C=C1 |
| CAS DataBase Reference | 3443-45-6(CAS DataBase Reference) |
| FDA UNII | CT0DC64E8Q |
| EPA Substance Registry System | 1-Pyrenebutanoic acid (3443-45-6) |
| UNSPSC Code | 12352106 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-50 | |||||||||
| Safety Statements | 26-36-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2916 39 90 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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1-PYRENEBUTYRIC ACID price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 257354 | 1-Pyrenebutyric acid 97% | 3443-45-6 | 1g | $110 | 2026-04-30 | Buy |
| Sigma-Aldrich | 257354 | 1-Pyrenebutyric acid 97% | 3443-45-6 | 5g | $338 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.41269 | 4-(1-Pyrenyl)-butyric acid for synthesis | 3443-45-6 | 1g | $105 | 2023-06-20 | Buy |
| TCI Chemical | P1213 | 1-Pyrenebutyric Acid >98.0%(GC)(T) | 3443-45-6 | 1g | $75 | 2026-04-30 | Buy |
| TCI Chemical | P1213 | 1-Pyrenebutyric Acid >98.0%(GC)(T) | 3443-45-6 | 5g | $225 | 2026-04-30 | Buy |
1-PYRENEBUTYRIC ACID Chemical Properties,Uses,Production
Description
Pyrenylbutyric acid is a derivative of pyrene hydrocarbon with a free carboxylic acid function. The reagent is useful as a control for experiments with other reactive pyrene derivatives such as pyrene NHS ester and pyrene azide. Carboxylic acid function can be activated by carbodiimides and other activating reagents.
Chemical Properties
Pale yellow or yellow-beige crystalline powder
Uses
1-Pyrenebutyric Acid is a fluorescent probe used to study proteins, lipids, nucleic acids and other biological systems. The fluorescence lifetime of 1-Pyrenebutyric Acid depends on local oxygen and free radical concentration.
General Description
1-Pyrenebutyric acid (PBA) is a conjugated polymer that has a large π system and a carboxylic group. It is majorly used in surface functionalization. It has a high fluorescence efficiency and stability that make it useful in optoelectronic applications.
Synthesis
7499-60-7
3443-45-6
General procedure for the synthesis of 1-pyrenylbutyric acid from 4-oxo-4-(pyren-1-yl)butyric acid: 1 g (2.78 mmol) of 4-oxo-4-(pyren-1-yl)butyric acid was dissolved in 30 mL of diethylene glycol, to which were added 0.59 g (10 mmol) of hydrazine hydrate and 0.56 g (10 mmol) of KOH.The reaction mixture was heated and refluxed for 2 h. The reaction mixture was subsequently poured into ice hydrochloric acid (25%) to produce a yellow precipitate. The solid was collected by filtration and recrystallized from ethanol to give 570 mg (71% yield) of 4-(pyrene-1-yl)butanoic acid. Molecular formula C20H16O2, molecular weight 288 g/mol. EI-MS: m/z (%) = 289 (16) [MH+], 288 (62) [M], 216 (20), 215 (100), 213 (11). High-resolution EI-MS (C20H16O2): calculated value 288.1150; measured value 288.1150.1H-NMR ([D6]-DMSO): δ (ppm) = 8.50-7.92 (9H, m, CHarom), 3.36 (2H, m, CH2C16H9), 2.41 (2H, m, CH2CO2H), 2.04 (2H, m, CH2CO2H), 2.04 (2H, m, CH2CO2H). 2.04 (2H, m, CH2).1H-NMR (CDCl3): δ (ppm) = 8.32-7.86 (9H, m, CHarom), 3.42 (2H, t, CH2C16H9, 3JHH = 7.57 Hz), 2.51 (2H, t, CH2CO2H, 3JHH = 7.00 Hz), 2.23 (2H, m, CH2, 3JHH = 7.00 Hz), 2.23 (2H, m, CH2, 3JHH = 3JHH). m, CH2, 3JHH = 7.57Hz, 3JHH = 7.00Hz).13C-NMR ([D6]-DMSO): δ (ppm) = 174.74 (1CO), 136.39-123.39 (9 CHarom, 7 Carom), 33.64-26.98 (1CH2CO2H, 2CH2).13C- NMR (CDCl3): δ (ppm) = 177.48 (1CO), 135.25-123.04 (9 CHarom, 7 Carom), 33.21-26.46 (1CH2CO2H, 2CH2).IR (KBr): ν (cm-1) = 3447w, 3037w, 2950m, 2934w, 2874w, 1695s, ν (cm-1) 2874w, 1695s, 1431w, 1275m, 1206m, 918w, 846s, 711w.
Purification Methods
Crystallise the butyric acid from *benzene, EtOH, EtOH/water (7:3 v/v) or *C6H6/AcOH. Dry it over P2O5. [Chu & Thomas J Am Chem Soc 108 6270 1986, Beilstein 9 IV 2731.]
References
[1] Patent: US7301043, 2007, B2. Location in patent: Page/Page column 7-8
[2] ACS Catalysis, 2016, vol. 6, # 11, p. 7398 - 7408
[3] New Journal of Chemistry, 2008, vol. 32, # 8, p. 1438 - 1448
[4] Journal of the American Chemical Society, 1941, vol. 63, p. 1682,1684
[5] Justus Liebigs Annalen der Chemie, 1937, vol. 531, p. 1,128
Abs/Em Maxima
343; 326; 313; 276; 265; 242; 234/377; 397 nm
1-PYRENEBUTYRIC ACID Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3958 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16511 | 58 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9052 | 58 |
View Lastest Price from 1-PYRENEBUTYRIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-15 | 1-PYRENEBUTYRIC ACID
3443-45-6
|
$2860.00 | 1KG | 98% | 1-10mt | Baoji Guokang Healthchem Co., Ltd. | |
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2026-07-10 | 1-PYRENEBUTYRIC ACID
3443-45-6
|
1kg | 98 | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-07-02 | 1-Pyrenebutyric Acid
3443-45-6
|
$2.20-8.80 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- 1-PYRENEBUTYRIC ACID
3443-45-6
- $2860.00
- 98%
- Baoji Guokang Healthchem Co., Ltd.
-
- 1-PYRENEBUTYRIC ACID
3443-45-6
- $0.00
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-Pyrenebutyric Acid
3443-45-6
- $2.20-8.80
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
