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ChemicalBook >> CAS DataBase List >>2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE

CAS No.
70298-89-4
Chemical Name:
2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE
Synonyms
N-(4-Pyridyl)pivalamide;4-(pivaloylamino)pyridine;N-(Pyridin-4-yl)pivalamide;N-(4-Pyridyl)pivalamide>2,2-Dimethyl-N-(4-pyridinyl)propanamid;2,2-Dimethyl-N-(4-pyridyl)propionamide;2,2-Dimethyl-N-pyridin-4-ylpropanamide;2,2-DIMETHYL-N-(4-PYRIDINYL)PROPANAMIDE;2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE;Propanamide, 2,2-dimethyl-N-4-pyridinyl-
CBNumber:
CB0404822
Molecular Formula:
C10H14N2O
Molecular Weight:
178.23
MDL Number:
MFCD00996248
MOL File:
70298-89-4.mol
MSDS File:
SDS
Last updated:2026-05-27 21:54:49
Product description Number Pack Size Price
2,2-Dimethyl-N-pyridin-4-yl-propionamide Aldrich MNO000019 1g $68.1
N-(4-Pyridyl)pivalamide >98.0%(GC) P2044 1g $94
N-(4-Pyridyl)pivalamide >98.0%(GC) P2044 5g $277
N-(PYRIDIN-4-YL)PIVALAMIDE 95% AR2618 5G $39
2,2-Dimethyl-N-pyridin-4-yl-propionamide VCA29889 10g $354
More product size

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE Properties

Melting point 73.9-74.0°C
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Methanol
form powder to crystal
color White to Almost white
InChI InChI=1S/C10H14N2O/c1-10(2,3)9(13)12-8-4-6-11-7-5-8/h4-7H,1-3H3,(H,11,12,13)
InChIKey JCMMVFHXRDNILC-UHFFFAOYSA-N
SMILES C(NC1C=CN=CC=1)(=O)C(C)(C)C
CAS DataBase Reference 70298-89-4

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
Hazard Codes  Xi,Xn
Risk Statements  22
HazardClass  IRRITANT
HS Code  29333990
NFPA 704
1
2 0

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich MNO000019 2,2-Dimethyl-N-pyridin-4-yl-propionamide Aldrich 70298-89-4 1g $68.1 2023-01-07 Buy
TCI Chemical P2044 N-(4-Pyridyl)pivalamide >98.0%(GC) 70298-89-4 1g $94 2024-03-01 Buy
TCI Chemical P2044 N-(4-Pyridyl)pivalamide >98.0%(GC) 70298-89-4 5g $277 2024-03-01 Buy
AstaTech AR2618 N-(PYRIDIN-4-YL)PIVALAMIDE 95% 70298-89-4 5G $39 2026-04-30 Buy
Biosynth VCA29889 2,2-Dimethyl-N-pyridin-4-yl-propionamide 70298-89-4 10g $354 2026-06-05 Buy
Product number Packaging Price Buy
MNO000019 1g $68.1 Buy
P2044 1g $94 Buy
P2044 5g $277 Buy
AR2618 5G $39 Buy
VCA29889 10g $354 Buy

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE Chemical Properties,Uses,Production

Chemical Properties

Light yellow solid

Definition

ChEBI: 2,2-Dimethyl-N-(4-pyridinyl)propanamide is a dihydropyridine.

Synthesis

4-Aminopyridine

504-24-5

Pivaloyl chloride

3282-30-2

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE

70298-89-4

a) General procedure for the synthesis of 2,2-dimethyl-N-(pyridin-4-yl)propionamide: 4-Aminopyridine (2 g, 21.3 mmol) was dissolved in dichloromethane (20 ml), to which pentanoyl chloride (3.1 ml, 25.6 mmol) and triethylamine (8.9 ml, 63.9 mmol) were added sequentially dropwise at room temperature. The reaction mixture was stirred at room temperature for 15 h. The reaction was subsequently quenched by addition of water. The organic layer was extracted with ethyl acetate and the combined organic layers were washed with saturated sodium chloride solution (50 ml), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with dichloromethane:methanol (20:1, v/v) as eluent. The fraction containing the target product was collected and concentrated to afford N-(pyridin-4-yl)trimethylacetamide as a white solid (3.6 g, 95% yield).1H-NMR (CDCl3, 300 MHz) data were as follows: δ= 8.47 (d, J = 6.1 Hz, 2H), 7.79 (br s, 1H), 7.52 (d, J = 6.0 Hz, 2H), 7.52 (d, J = 6.0 Hz, 2H). 1.32 (s, 9H).

References

[1] Synthesis, 2009, # 13, p. 2267 - 2277
[2] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 16
[3] Chemistry - A European Journal, 2013, vol. 19, # 20, p. 6435 - 6442
[4] Molecules, 2003, vol. 8, # 9, p. 678 - 686
[5] European Journal of Medicinal Chemistry, 2005, vol. 40, # 1, p. 15 - 23

13534-98-0
70298-89-4
Synthesis of 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE from 4-Amino-3-bromopyridine
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2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE  pictures 2025-11-18 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE
70298-89-4
$1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE pictures 2019-12-26 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE
70298-89-4
$1.00 1KG 99% 200kg Career Henan Chemical Co

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE Spectrum

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE 2,2-DIMETHYL-N-(4-PYRIDINYL)PROPANAMIDE 2,2-Dimethyl-N-pyridin-4-ylpropanamide 2,2-Dimethyl-N-(4-pyridinyl)propanamide ,97% N-(Pyridin-4-yl)pivalamide 4-(2,2,2-TriMethylacetaMido)pyridine, 97% N-(4-Pyridyl)pivalamide 2,2-Dimethyl-N-(4-pyridinyl)propanamid Propanamide, 2,2-dimethyl-N-4-pyridinyl- 2,2-Dimethyl-N-(4-pyridyl)propionamide 2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE ISO 9001:2015 REACH N-(4-Pyridyl)pivalamide> 4-(pivaloylamino)pyridine 2,2-Dimethyl-N-pyridin-4-yl- propionamide, 95% 70298-89-4 Amines Pyridines API intermediates
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