Alalevonadifloxacin
- CAS No.
- 706809-20-3
- Chemical Name:
- Alalevonadifloxacin
- Synonyms
- WCK-2349;Alalevonadifloxacin;L-Alanine, 1-[(5S)-2-carboxy-9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizin-8-yl]-4-piperidinyl ester;(S)-8-[4-[[(S)-2-Aminopropanoyl]oxy]-1-piperidyl]-9-fluoro-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic Acid
- CBNumber:
- CB04919764
- Molecular Formula:
- C22H26FN3O5
- Molecular Weight:
- 431.46
- MDL Number:
- MOL File:
- 706809-20-3.mol
| Product description | Number | Pack Size | Price |
| Alalevonadifloxacin 95% | A2665482 | 1mg | $91 |
| Alalevonadifloxacin 95% | A2665482 | 5mg | $226 |
| Alalevonadifloxacin 95% | A2665482 | 10mg | $329 |
| Alalevonadifloxacin 95% | A2665482 | 25mg | $509 |
| Alalevonadifloxacin 95% | A2665482 | 50mg | $684 |
| FDA UNII | 57B7E1D1TG |
|---|
Alalevonadifloxacin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Ambeed | A2665482 | Alalevonadifloxacin 95% | 706809-20-3 | 1mg | $91 | 2026-06-05 | Buy |
| Ambeed | A2665482 | Alalevonadifloxacin 95% | 706809-20-3 | 5mg | $226 | 2026-06-05 | Buy |
| Ambeed | A2665482 | Alalevonadifloxacin 95% | 706809-20-3 | 10mg | $329 | 2026-06-05 | Buy |
| Ambeed | A2665482 | Alalevonadifloxacin 95% | 706809-20-3 | 25mg | $509 | 2026-06-05 | Buy |
| Ambeed | A2665482 | Alalevonadifloxacin 95% | 706809-20-3 | 50mg | $684 | 2026-06-05 | Buy |
Alalevonadifloxacin Chemical Properties,Uses,Production
Description
Alalevonadifloxacin(Emrok O) is a structurally similar prodrug of Levonadifloxacin developed by Wockhardt that can be administered orally, providing an alternative route of administration for the same indication.
Uses
Emrok O is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI), including diabetic foot infections, and methicillin-resistant Staphylococcus aureus (MRSA) infections.
Mechanism of action
Emrok O belongs to the fluoroquinolone antibiotic class and works by inhibiting bacterial DNA gyrase.
Synthesis
Starting from 2-bromo-4,5-difluoroacetylaniline, it was reacted with crotonaldehyde under Skraup-Doeber-VonMiller reaction conditions to generate quinoline 2 in 67% yield. Pd-on-carbon catalytic hydrogenation was used to reduce the carbon-bromine bond in 2, and the catalyst was removed by filtration. Platinum-on-carbon was added to the reaction mixture and the hydrogenation conditions were again applied to give tetrahydroquinoline 3 in 97% yield. Tetrahydroquinoline 3 was reacted with 2,3-di-O-benzyl-L-tartaric acid (L-DBTA) and subsequently recrystallized from 60% methanol-water solution to give S-isomer 4 in 35% yield and 100% enantiomeric excess. The recovered R-isomer could be racemized by treatment with methanesulfonic acid. Compound 4 was reacted with diethylethoxymethylvinylmalonate in polyphosphoric acid and subsequently treated with hydrochloric acid to give tricyclic acid 5 in 88% yield. The tricyclic acid 5 chelates with the in situ generated borotriacetate to form the cyclic boronic ester complex 6. The cyclic boronic ester complex 6 is reacted with 4-hydroxypiperidine to afford levonadifloxacin 8 in good yield in a two-step reaction.Levonadifloxacin 8 was coupled with Boc-alanine, followed by removal of the Boc protecting group and salt formation with methanesulfonic acid to afford alalevonadifloxacin (I) in 95% yield.
Alalevonadifloxacin Preparation Products And Raw materials
Raw materials
Preparation Products
Alalevonadifloxacin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | hanfangpharma@126.com 18017580634 | hanfangpharma@126.com | China | 25800 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | 58 |
