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JMJD3 antibody

CAS No.
Chemical Name:
JMJD3 antibody
Synonyms
JMJD3 antibody
CBNumber:
CB05648865
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

JMJD3 antibody Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human;Mouse

Background

The methylation state of lysine residues in histone proteins is a major determinant of the formation of active and inactive regions of the genome and is crucial for proper programming of the genome during development. Jumonji C domain-containing proteins represent the largest class of potential histone demethylase proteins. The JmjC domain can catalyze the demethylation of mono-, di-, and tri-methyl lysine residues via an oxidative reaction that requires iron and α-ketoglutarate. Based on homology, both humans and mice contain at least 30 such proteins, which can be divided into 7 separate families. The three members of the UTX/UTY family include the ubiquitously transcribed X chromosome tetratricopeptide repeat protein, the ubiquitously transcribed Y chromosome tetratricopeptide repeat protein, and JmjC domain-containing protein 3. This family of proteins has been shown to demethylate both di- and tri-methyl histone H3 Lys 27. The UTX gene escapes X inactivation in females and is ubiquitously expressed. UTX functions to regulate HOX gene expression during development. JMJD3 functions to regulate gene expression in macrophages responding to various inflammatory stimuli and has been shown to be upregulated in prostate cancer. Both UTX and JMJD3 interact with mixed-lineage leukemia complexes 2 and 3, both of which have been shown to methylate histone H3 at Lys4. The UTY gene is expressed in most tissues in the male mouse.

References

[1] Kubicek, S. et al. (2006) Ernst Schering Res Found Workshop, 1-27.
[2] Lin, W. and Dent, S.Y. (2006) Curr Opin Genet Dev 16, 137-42.
[3] Klose, R.J. et al. (2006) Nat Rev Genet 7, 715-27.
[4] Agger, K. et al. (2007) Nature 449, 731-4.
[5] Lan, F. et al. (2007) Nature 449, 689-94.
[6] Lee, M.G. et al. (2007) Science 318, 447-50.
[7] De Santa, F. et al. (2007) Cell 130, 1083-94.
[8] Xiang, Y. et al. (2007) Cell Res 17, 850-7.
[9] Greenfield, A. et al. (1998) Hum Mol Genet 7, 737-42.
[10] Greenfield, A. et al. (1996) Nat Genet 14, 474-8.

JMJD3 antibody Preparation Products And Raw materials

Raw materials

Preparation Products

JMJD3 antibody Suppliers

Global( 54)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Universal Biotech Co.,Ltd 15921930842 15921930842 yh-wang@univ-bio.com China 25021 58
GeneTex, Inc. 0755-26755892 1-949-553-1900 international@genetex.com China 6092 58
NSJ Bioreagents 858.663.9055 8586639055 NSJBioname@qq.com China 6941 58
Enzo Biochem Inc Enzo Biochem Inc. 13797054060 Enzoname@qq.com China 6174 58
Biosynth Ltd 18886812933 sales@biosynth.com China 6218 58
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Rockland Immunochemicals Inc 1-+1 484.791.3823 14847913823 orders@rockland.com China 4881 58
Abmart Inc 4006-123-828 13162017139 market@ab-mart.com China 6917 58
Signalway Antibody LLC 025-58868422 info@sabbiotech.com China 6243 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 6051 58
JMJD3 antibody
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