一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Rab Family Antibody Sampler Kit

CAS No.
Chemical Name:
Rab Family Antibody Sampler Kit
Synonyms
Rab Family Antibody Sampler Kit
CBNumber:
CB05677827
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Rab Family Antibody Sampler Kit Chemical Properties,Uses,Production

Description

The Rab Family Antibody Sampler Kit provides an economical means to evaluate the presence and status of Rab proteins in cells. This kit provides enough primary and secondary antibodies to perform two Western blot experiments per primary antibody.

Background

Rab family proteins are GTPases and members of the Ras superfamily of monomeric G proteins. These membrane-associated proteins are involved in many aspects of vesicle-mediated transport, taking part in the initial vesicle formation, transport of vesicles along the cytoskeleton, and eventual fusion of vesicle and target membranes. Rab4 is localized at early endosomes/recycling endosomes and functions as a key regulator for sorting/recycling of membrane and proteins. Both Rab4A and Rab4B isoforms are localized to similar cellular compartments and are believed to have similar functions. Rab4 interacts with several Rab4 effectors in a complex on a special endosome site to promote membrane/protein recycling. Rab5 is localized to the plasma membrane and early endosome and functions as a key regulator of vesicle trafficking during early endocytosis. The conformational change between Rab5-GTP and Rab5-GDP is essential for its biological function as a rate-limiting regulator at multiple steps during endocytosis. Similar to Rab4, Rab5 also interacts with specific Rab5 effectors on a specialized endosomal Rab domain to promote recycling between endosome and the plasma membrane. Both Rab7 and Rab9 are located in late endosomes but exert different functions. Rab7 associates with the RIPL effector protein to control membrane trafficking from early to late endosome and to lysosomes. Rab7 also helps to regulate growth receptor endocytic trafficking and degradation, and maturation of phagosome and autophagic vacuoles. Rab9 interacts with its effector proteins p40 and TIP47 to promote the MPR-associated lysosomal enzyme transport between late endosomes and the trans Golgi network. Rab11 functions as a key regulator in the recycling of perinuclear, plasma membrane and Golgi compartment endosomes. Despite some overlap, distinct differences exist between Rab11a and Rab11b in both their cellular distribution and functional roles. Rab11a is ubiquitously expressed while Rab11b is found mainly in the heart and brain. Like other Rab proteins, Rab11 functions when associated with Rab11 family interacting proteins. The three distinct classes of Rab11 FIPs all share a conserved carboxy-terminal Rab-binding domain that allows Rab-FIP protein interaction. When bound together, these proteins are thought to regulate membrane-associated protein sorting.

References

[1] Zerial, M. and McBride, H. (2001) Nat Rev Mol Cell Biol 2, 107-17.
[2] van der Sluijs, P. et al. (1992) Cell 70, 729-40.
[3] Deneka, M. et al. (2003) EMBO J 22, 2645-57.
[4] Krawczyk, M. et al. (2007) Nucleic Acids Res 35, 595-605.
[5] van der Bliek, A.M. (2005) Nat Cell Biol 7, 548-50.
[6] Haas, A.K. et al. (2005) Nat Cell Biol 7, 887-93.
[7] Feng, Y. et al. (1995) J Cell Biol 131, 1435-52.
[8] Méresse, S. et al. (1995) J Cell Sci 108 ( Pt 11), 3349-58.
[9] Ceresa, B.P. and Bahr, S.J. (2006) J Biol Chem 281, 1099-106.
[10] J?ger, S. et al. (2004) J Cell Sci 117, 4837-48.

Rab Family Antibody Sampler Kit Preparation Products And Raw materials

Raw materials

Preparation Products

Rab Family Antibody Sampler Kit Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Guangzhou Bingheng Biotechnology Co., Ltd. 13631342304 CHINA 6888 58
Rab Family Antibody Sampler Kit
潍坊市| 通州区| 西安市| 淄博市| 宜兴市| 新郑市| 阿坝县| 鱼台县| 咸丰县| 汝城县| 寻乌县| 林口县| 九龙县| 芷江| 固原市| 宁陕县| 舒兰市| 三都| 应城市| 阳曲县| 天峨县| 克拉玛依市| 遂川县| 蒙城县| 枣阳市| 于都县| 武城县| 彭山县| 喀喇| 万源市| 莱西市| 绩溪县| 新源县| 洛扎县| 贵港市| 咸阳市| 浏阳市| 宁河县| 邯郸市| 青岛市| 商洛市|