Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Flotillins belong to a family of lipid raft-associated integral membrane proteins that carry an evolutionarily conserved domain called the prohibitin homology domain. Flotillin members are ubiquitously expressed and located in noncaveolar microdomains on the plasma membrane where they support signal transduction and regulate lipid raft motility and localization. Two flotillin members have been described, flotillin-1 and flotillin-2. In addition to its colocalization with lipid rafts on the plasma membrane, flotillin-1 also has been found in compartments of the endocytic and autophagosomal pathways, such as recycling/late endosomes, the Golgi complex, and the nucleus. Flotillin-2 is mainly localized to the plasma membrane and is prevalent in cell-cell contact sites. However, overexpressed flotillin-2 has also been found in the late endosome. Both flotillin-1 and flotillin-2 are commonly used as lipid raft-associated markers.

References

[1] Morrow, I.C. and Parton, R.G. (2005) Traffic 6, 725-40.
[2] Langhorst, M.F. et al. (2005) Cell Mol Life Sci 62, 2228-40.
[3] Stuermer, C.A. and Plattner, H. (2005) Biochem Soc Symp , 109-18.
[4] Fernow, I. et al. (2007) Eur J Cell Biol 86, 345-52.
[5] Neumann-Giesen, C. et al. (2007) J Cell Sci 120, 395-406.
[6] Liu, J. et al. (2005) J Biol Chem 280, 16125-134.
[7] Santamaría, A. et al. (2005) Mol Cell Biol 25, 1900-11.
[8] Solomon, S. et al. (2002) Immunobiology 205, 108-19.
[9] Neumann-Giesen, C. et al. (2004) Biochem J 378, 509-518.

Raw materials

Preparation Products