Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Nuclear protein localization protein 4 was originally identified as a yeast nuclear transport protein that was later recognized as a critical component of the endoplasmic reticulum-associated degradation pathway. Mammalian NPL4 protein has an amino-terminal ubiquitin-like domain containing a p97 binding site, and a conserved carboxy-terminal zinc finger motif responsible for binding ubiquitinated target proteins. NPL4 binds ubiquitin fusion degradation protein 1 to form a heterodimer that associates with the p97 AAA-ATPase, creating a protein complex that mediates delivery of ubiquitinated ER proteins to the proteasome.

References

[1] Corbett, A. et al. (1996) Exp Cell Res 229, 212-6.
[2] Meyer, H.H. et al. (2002) EMBO J 21, 5645-52.
[3] Bebeacua, C. et al. (2012) Proc Natl Acad Sci U S A 109, 1098-103.
[4] Stolz, A. et al. (2011) Trends Biochem Sci 36, 515-23.
[5] Meyer, H.H. et al. (2000) EMBO J 19, 2181-92.

Raw materials

Preparation Products