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PIP4K2A (D83C1) Rabbit mAb

CAS No.
Chemical Name:
PIP4K2A (D83C1) Rabbit mAb
Synonyms
PIP4K2A (D83C1) Rabbit mAb
CBNumber:
CB06277705
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

PIP4K2A (D83C1) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Bovine;Pig;Human;Mouse;Rat;Monkey

Background

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, is one of three known members of the type II PIP kinase family, consisting of PIP4K2A, PIP4K2B, and PIP4K2C. Each catalyzes the phosphorylation of phosphatidylinositol 5-monophosphate to form phosphatidylinositol 4,5-bisphosphate. Originally thought to be a PI 4-P 5-Kinase, PIP4K2A was subsequently shown to phosphorylate the 4-position of PI 5-P, thus defining a new family of lipid kinases. Ubiquitously expressed with highest levels in the brain, mutations in PIP4K2A have been described in patients with Schizophrenia and other neuronal disorders.The levels of PI 5-P change significantly in response to physiological and pathological stimuli, as well as cell transformation with nucleophosmin anaplastic lymphoma tyrosine kinase. In contrast, hypoosmotic shock and histamine decrease cellular levels of PI 5-P. PIP4K2A has been hypothesized to play a role in suppressing mitogen-dependent increases in PI 5-P in response to DNA damage and cellular stress. PIP4K2A regulates the levels of PI 5-P in the nucleus by converting the PI 5-P to PI 4,5-P2, thus preventing PI 5-P from interacting with and regulating the ability of ING2 to activate p53 and p53-dependent apoptotic pathways. PIP4K2A has been shown to form a heterodimer with PIP4K2B resulting in its recruitment to the nucleus. Interestingly, PIP4K2A is 2000-fold more active than PIP4K2B in this context, suggesting that the two lipid kinases act in tandem, with PIP4K2B acting as the targeting subunit and PIP4K2A the catalytic component. PIP4Ks may also play a role in lipid vesicle formation and/or Golgi homeostasis.

References

[1] Divecha, N. et al. (1995) Biochem J 309 ( Pt 3), 715-9.
[2] Boronenkov, I.V. and Anderson, R.A. (1995) J Biol Chem 270, 2881-4.
[3] Rameh, L.E. et al. (1997) Nature 390, 192-6.
[4] Stopkova, P. et al. (2003) Am J Med Genet B Neuropsychiatr Genet 123B, 50-8.
[5] Schwab, S.G. et al. (2006) Mol Psychiatry 11, 837-46.
[6] Bakker, S.C. et al. (2007) Genes Brain Behav 6, 113-9.
[7] Fedorenko, O. et al. (2008) Psychopharmacology (Berl) 199, 47-54.
[8] Salazar, G. et al. (2009) J Biol Chem 284, 1790-802.
[9] Morris, J.B. et al. (2000) FEBS Lett 475, 57-60.
[10] Sbrissa, D. et al. (2004) Endocrinology 145, 4853-65.

PIP4K2A (D83C1) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

PIP4K2A (D83C1) Rabbit mAb Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Guangzhou Keda Heng New Technology Co., Ltd. 17328662120 CHINA 6139 58
Shanghai Haoye Biotechnology Co., Ltd. 15121098156 CHINA 6534 58
PIP4K2A (D83C1) Rabbit mAb
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