N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE
![N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE Structure](StructureFile/ChemBookStructure21/GIF/CB0804585.gif)
- CAS No.
- Chemical Name:
- N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE
- Synonyms
- PNU-282987 HYDRATE;N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE
- CBNumber:
- CB0804585
- Molecular Formula:
- C14H20Cl2N2O2
- Molecular Weight:
- 319.2268
- MDL Number:
- MFCD09039099
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| PNU-282987 hydrate solid, ≥98% (HPLC) | P6499 | 10mg | $224 |
| PNU-282987 hydrate solid, ≥98% (HPLC) | P6499 | 50mg | $788 |
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: >10mg/mL |
| form | solid |
| InChI | 1S/C14H17ClN2O.ClH.H2O/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17;;/h1-4,10,13H,5-9H2,(H,16,18);1H;1H2/t13-;;/m0../s1 |
| InChIKey | OCWLMMBVXIESNP-GXKRWWSZSA-N |
| SMILES | Cl[H].[H]O[H].Clc1ccc(cc1)C(=O)N[C@H]2CN3CCC2CC3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE price More Price(2)
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE Chemical Properties,Uses,Production
Uses
PNU-282987 hydrate has been used to check its activity in wound repair by inhibiting AGE (advanced glycation end products)-mediated tumor necrosis factor-α (TNF-α) production in a streptozotocin (STZ)-induced diabetic mouse model. It has also been used to evaluate the effects of nicotinic α-7 acetylcholine receptor (nAChRα7) activation on non-diabetic wound healing.
Biochem/physiol Actions
Decreased expression of a homomeric alpha7 nicotinic acetylcholine receptor (nAChR) is connected with inability to process sensory information in schizophrenia. PNU-282987 is a novel selective agonist of the alpha7 nAChR that evoked whole-cell currents from cultured rat hippocampal neurons that were sensitive to the selective alpha7 nAChR antagonist methyllycaconitine (MLA) and enhanced GABAergic synaptic activity. The alpha7 nAChR agonist PNU-282987 improves auditory gating and enhances hippocampal oscillatory activity. These results provide further support for the concept that drugs that selectively activate alpha7 nAChRs may offer a novel, potential pharmacotherapy in treatment of schizophrenia.
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6394 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6594 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| Merck KGaA | 58 |
| Santa Cruz Biotechnology Inc | 58 |
