ζ-Stat
- CAS No.
- 3316-02-7
- Chemical Name:
- ζ-Stat
- Synonyms
- ζ-Stat;NSC37044;ZETA-STAT;ζ-Stat (NSC37044);NVP-LCQ195 ，E2404;ζ-Stat (ZETA-STAT);6-naphthalenetrisulfonicacid,8-hydroxy-3;3,6-Naphthalenetrisulfonicacid,8-hydroxy-1;8-hydroxy-1,3,6-naphthalenetrisulfonic acid;8-hydroxynaphthalene-1,3,6-trisulfonic acid
- CBNumber:
- CB0860691
- Molecular Formula:
- C10H8O10S3
- Molecular Weight:
- 384.35952
- MDL Number:
- MFCD00036006
- MOL File:
- 3316-02-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Zeta-stat | DAA31602 | 10mg | $853.8 |
| Zeta-stat | DAA31602 | 25mg | $1392 |
| Zeta-stat | DAA31602 | 50mg | $2227 |
| ζ-Stat 98.98% | CS-0088118 | 5mg | $390 |
| ζ-Stat 98.98% | CS-0088118 | 10mg | $617 |
| More product size | |||
| storage temp. | Store at -20°C |
|---|---|
| form | Solid |
| color | Light brown to brown |
| Water Solubility | Water : 62.5 mg/mL (162.61 mM; Need ultrasonic) |
| FDA UNII | 995HWE6PJS |
| EPA Substance Registry System | 1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy- (3316-02-7) |
ζ-Stat price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DAA31602 | Zeta-stat | 3316-02-7 | 10mg | $853.8 | 2026-06-04 | Buy |
| Biosynth | DAA31602 | Zeta-stat | 3316-02-7 | 25mg | $1392 | 2026-06-04 | Buy |
| Biosynth | DAA31602 | Zeta-stat | 3316-02-7 | 50mg | $2227 | 2026-06-04 | Buy |
| ChemScene | CS-0088118 | ζ-Stat 98.98% | 3316-02-7 | 5mg | $390 | 2026-06-04 | Buy |
| ChemScene | CS-0088118 | ζ-Stat 98.98% | 3316-02-7 | 10mg | $617 | 2026-06-04 | Buy |
ζ-Stat Chemical Properties,Uses,Production
Chemical Properties
1-Hydroxynaphthalene-3,6,8-trisulfonic acid [3316-02-7]. (8-hydroxynaphthalene-1,3,6-trisulfonic acid), oxy Koch acid, C10H8O10S3, Mr 384.3, and its alkali-metal salts are readily soluble in water. Amination at 170℃ gives 1-aminonaphthalene-3,6,8-trisulfonic acid. Diazo coupling takes place in the 2-position.
Production Methods
1-Aminonaphthalene-3,6,8-trisulfonic acid is heated with dilute sulfuric acid at 180℃ under pressure for 20 h. After the mixture is run into excess sodium hydroxide solution, ammonia is removed by heating and the total liquor is used directly for the production of chromotropic acid by caustic fusion.
Biological Activity
ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor with IC50 of 5 μM. ζ-Stat reduces proliferation and induces apoptosis in melanoma cell lines, with antitumor activity in vitro.
in vitro
ζ-Stat (0.1-20 μM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level.
target
| aPKC-ζ < span> 5 μM (IC 50 ) |
ζ-Stat Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 4000 | 55 |
| Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. | 027-65388397 18164111589 | 3321478047@qq.com | China | 2005 | 55 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| DC Chemicals | 021-58447131 13564518121 | doncunbiosci@gmail.com | China | 591 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
