Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey;Bovine

Background

TAK1 is a mitogen-activated protein kinase kinase kinase that can be activated by TGF-β, bone morphogenetic protein, and other cytokines, including IL-1. In vivo activation of TAK1 requires association with TAK1 binding protein 1, which triggers phosphorylation of TAK1. Another adaptor protein, TAB2, links TAK1 with TRAF6 and mediates TAK1 activation upon IL-1 stimulation. Once activated, TAK1 phosphorylates MAPK kinases MKK4 and MKK3/6, which activate p38 MAPK and JNK, respectively. In addition, TAK1 activates the NF-κB pathway by interacting with TRAF6 and phosphorylating the NF-κB inducing kinase.

References

[1] Yamaguchi, K. et al. (1995) Science 270, 2008-11.
[2] Ninomiya-Tsuji, J. et al. (1999) Nature 398, 252-6.
[3] Shibuya, H. et al. (1996) Science 272, 1179-82.
[4] Sakurai, H. et al. (2000) FEBS Lett 474, 141-5.
[5] Takaesu, G. et al. (2000) Mol Cell 5, 649-58.
[6] Onodera, Y. et al. (2015) FEBS Open Bio 5, 492-501.

Raw materials

Preparation Products