2-(Di-tert-butylphosphino)biphenyl
- CAS No.
- 224311-51-7
- Chemical Name:
- 2-(Di-tert-butylphosphino)biphenyl
- Synonyms
- JohnPhos;2-(DI-T-BUTYLPHOSPHINO)BIPHENYL;ditert-butyl-(2-phenylphenyl)phosphane;(2-biphenyl)di-tert-butylphosphine;JnhnPhos;BIPHENYL-2-YL-DI-TERT-BUTYL-PHOSPHANE;2-(Di-tert-butylphosphino)-1,1'-biphenyl;98% JohnPhos;JohnPhos 97%;2-(Di-t-butyL
- CBNumber:
- CB1108350
- Molecular Formula:
- C20H27P
- Molecular Weight:
- 298.4
- MDL Number:
- MFCD01862440
- MOL File:
- 224311-51-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| JohnPhos 97% | 638439 | 1g | $67.3 |
| JohnPhos 97% | 638439 | 5g | $320 |
| 2-(Di-tert-butylphosphino)biphenyl >98.0%(GC) | D3387 | 1g | $62 |
| 2-(Di-tert-butylphosphino)biphenyl >98.0%(GC) | D3387 | 5g | $256 |
| 2-(Di-t-butylphosphino))-1,1'-biphenyl, 99% JohnPhos 99% | 15-1045 | 500mg | $32 |
| More product size | |||
| Melting point | 86-88 °C (lit.) |
|---|---|
| Boiling point | 405.5±24.0 °C(Predicted) |
| Density | 1 g/cm3 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated, Sonicated) |
| form | Crystals or Crystalline Powder |
| color | White |
| Water Solubility | Insoluble |
| BRN | 8322131 |
| Stability | Air Sensitive |
| InChI | InChI=1S/C20H27P/c1-19(2,3)21(20(4,5)6)18-15-11-10-14-17(18)16-12-8-7-9-13-16/h7-15H,1-6H3 |
| InChIKey | CNXMDTWQWLGCPE-UHFFFAOYSA-N |
| SMILES | P(C1=CC=CC=C1C1=CC=CC=C1)(C(C)(C)C)C(C)(C)C |
| CAS DataBase Reference | 224311-51-7(CAS DataBase Reference) |
| FDA UNII | 5Y743P380H |
| UNSPSC Code | 12352002 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H413 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 36/37/39-26-22 |
| WGK Germany | 3 |
| F | 10-23 |
| TSCA | No |
| HazardClass | AIR SENSITIVE |
| HS Code | 29029090 |
| Storage Class | 11 - Combustible Solids |
2-(Di-tert-butylphosphino)biphenyl price More Price(102)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 638439 | JohnPhos 97% | 224311-51-7 | 1g | $67.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 638439 | JohnPhos 97% | 224311-51-7 | 5g | $320 | 2026-04-30 | Buy |
| TCI Chemical | D3387 | 2-(Di-tert-butylphosphino)biphenyl >98.0%(GC) | 224311-51-7 | 1g | $62 | 2026-04-30 | Buy |
| TCI Chemical | D3387 | 2-(Di-tert-butylphosphino)biphenyl >98.0%(GC) | 224311-51-7 | 5g | $256 | 2026-04-30 | Buy |
| Strem Chemicals | 15-1045 | 2-(Di-t-butylphosphino))-1,1'-biphenyl, 99% JohnPhos 99% | 224311-51-7 | 500mg | $32 | 2026-04-30 | Buy |
2-(Di-tert-butylphosphino)biphenyl Chemical Properties,Uses,Production
Reactions
- Ligand used in the palladium-catalyzed synthesis of aromatic amines from aryl chlorides, bromides and triflates.
- Ligand employed in a very active and general catalyst for Suzuki coupling reactions using aryl chlorides, bromides and triflates.
- Ligand used in palladium-catalyzed synthesis of oxindoles from α-chloroacetanilides.
- Effective ligand used in palladium-catalyzed arylation of thiazoles.
- Used in the formation of 2-benzylindolines via sequential palladium-catalyzed N-arylation/cyclization/C-arylation.
- Selective in the palladium-catalyzed arylation of silyl enol ethers formed from copper-catalyzed reduction of enones.
Chemical Properties
white to light yellow crystal powde
Uses
suzuki reaction
Uses
2-(Di-tert-butylphosphino)biphenyl (also known as JohnPhos) is a Buchwald ligand that is highly efficient in palladium-catalyzed reactions.
General Description
JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy.
reaction suitability
reaction type: Cross Couplings
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation
reagent type: ligand
reaction type: Heck Reaction
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
Synthesis
13716-10-4
2052-07-5
224311-51-7
Grignard reagent was prepared by adding 40 g of 2-bromobiphenyl, 5 g of magnesium shavings and 400 ml of anhydrous THF to a 1 L three-necked flask under nitrogen protection and refluxed for 2 hours. After the reaction mixture was cooled to room temperature, 2 g of tetrakis (triphenylphosphine) palladium was added and stirred for 30 minutes. Subsequently, 33 g of di-tert-butylphosphonium chloride was slowly added dropwise at room temperature and the reaction mixture was refluxed for 2 hours after completion of the dropwise addition. Upon completion of the reaction, the mixture was quenched by slow dropwise addition to 200 mL of saturated aqueous ammonium chloride solution under cooling in an ice water bath. The organic phase was separated, dissolved and crystallized by adding methanol, and filtered to give 49 g of white solid 2-(di-tert-butylphosphino)biphenyl in 95.7% yield.
References
[1] Patent: CN105859774, 2016, A. Location in patent: Paragraph 0062; 0063; 0064; 0065; 0066; 0067; 0068; 0069
[2] Journal of the American Chemical Society, 1999, vol. 121, # 41, p. 9550 - 9561
[3] Journal of the American Chemical Society, 1999, vol. 121, # 18, p. 4369 - 4378
2-(Di-tert-butylphosphino)biphenyl Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XINXIANG RUNYU MATERIAL CO., LTD. | +86-13592593621; +8613592593621 | sales@runvmat.com | China | 460 | 58 |
| Henan Research New Materials Co., Ltd. | +86-18903931628 +86-18903931531 | sales036@researchvip.com | China | 302 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8740 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14014 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| AB PharmaTech,LLC | 323-480-4688 | sales@acrospharmatech.com | United States | 989 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
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Related Qustion
Ask a questionView Lastest Price from 2-(Di-tert-butylphosphino)biphenyl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-15 | 2-(Di-tert-butylphosphino)biphenyl
224311-51-7
|
$16.50-254.00 | 5g | 0.98 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-06-04 | 2-(Di-tert-butylphosphino)biphenyl
224311-51-7
|
1g | 99%；sales036@researchvip.com;18903931628; | 100KG | Henan Research New Materials Co., Ltd. | ||
 |
2026-03-20 | 2-(Di-tert-butylphosphino)biphenyl
224311-51-7
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2-(Di-tert-butylphosphino)biphenyl
224311-51-7
- $16.50-254.00
- 0.98
- Shanghai UCHEM Inc.
-
- 2-(Di-tert-butylphosphino)biphenyl
224311-51-7
- $0.00
- 99%；sales036@researchvip.com;18903931628;
- Henan Research New Materials Co., Ltd.
-
- 2-(Di-tert-butylphosphino)biphenyl
224311-51-7
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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