2-BROMO-5-IODOBENZOIC ACID
- CAS No.
- 25252-00-0
- Chemical Name:
- 2-BROMO-5-IODOBENZOIC ACID
- Synonyms
- 2-BROMO-5-IODOBENZOIC ACID;Benzoic acid, 2-bromo-5-iodo-;2-Bromo-5-iodobenzoic acid 97%;2-Bromine-5-Iodine Benzoic Acids
- CBNumber:
- CB1114461
- Molecular Formula:
- C7H4BrIO2
- Molecular Weight:
- 326.91
- MDL Number:
- MFCD00079716
- MOL File:
- 25252-00-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Bromo-5-iodobenzoic acid 97% | 665339 | 10g | $250 |
| 2-Bromo-5-iodobenzoic acid 99+% (HPLC) ≥99%(HPLC) | 230009 | 1g | $170 |
| 2-Bromo-5-iodobenzoic acid 99+% (HPLC) ≥99%(HPLC) | 230009 | 5g | $233 |
| 2-Bromo-5-iodobenzoic acid 99+% (HPLC) ≥99%(HPLC) | 230009 | 25g | $545 |
| 2-Bromo-5-iodobenzoic acid 99+% (HPLC) ≥99%(HPLC) | 230009 | 100g | $1373 |
| More product size | |||
| Melting point | 171-175 °C |
|---|---|
| Boiling point | 371.2±32.0 °C(Predicted) |
| Density | 2.331±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 2.50±0.10(Predicted) |
| form | Solid |
| color | Pale Brown to Brown |
| Sensitive | Light Sensitive |
| InChI | InChI=1S/C7H4BrIO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11) |
| InChIKey | QPKKBDSNZFSSOD-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(I)=CC=C1Br |
| CAS DataBase Reference | 25252-00-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-BROMO-5-IODOBENZOIC ACID price More Price(84)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 665339 | 2-Bromo-5-iodobenzoic acid 97% | 25252-00-0 | 10g | $250 | 2026-04-30 | Buy |
| Usbiological | 230009 | 2-Bromo-5-iodobenzoic acid 99+% (HPLC) ≥99%(HPLC) | 25252-00-0 | 1g | $170 | 2026-06-03 | Buy |
| Usbiological | 230009 | 2-Bromo-5-iodobenzoic acid 99+% (HPLC) ≥99%(HPLC) | 25252-00-0 | 5g | $233 | 2026-06-03 | Buy |
| Usbiological | 230009 | 2-Bromo-5-iodobenzoic acid 99+% (HPLC) ≥99%(HPLC) | 25252-00-0 | 25g | $545 | 2026-06-03 | Buy |
| Usbiological | 230009 | 2-Bromo-5-iodobenzoic acid 99+% (HPLC) ≥99%(HPLC) | 25252-00-0 | 100g | $1373 | 2026-06-03 | Buy |
2-BROMO-5-IODOBENZOIC ACID Chemical Properties,Uses,Production
Chemical Properties
White powder
Synthesis
88-65-3
25252-00-0
The general procedure for the synthesis of 2-bromo-5-iodobenzoic acid from o-bromobenzoic acid was as follows: Concentrated sulfuric acid (294.4 g) was added to the reaction flask and the temperature of the reaction system was lowered to 5-10 °C. Subsequently, o-bromobenzoic acid (126.9 g, 0.456 mol) and dichloromethane (687 g) were added. The reaction system was warmed to 15-20 °C and 1,3-diiodo-5,5-dimethyl-acetylurea (total 126.9 g, 0.25 mol, prepared according to Example 1) was added in 4 batches. After 2 hours of reaction at 15-20°C, the reaction solution was slowly poured into ice water (686.9 g) and the reactor temperature was controlled at 15-25°C. Next, 45.8 g ester kettle was added followed by methyl tertiary butyl ether (MTBE, 800 g) and the mixture was stirred for extraction for 20 min. After standing and stratifying, the upper organic phase was separated and collected. The aqueous phase was extracted one more time with MTBE (458 g) and after stirring for 20 min, the layers were separated and the upper organic phase was collected. All the organic phases were combined, kept at 15-25 °C, and treated by adding 5% aqueous sodium sulfite (126.04 g) for 30 min, and after layering, the organic phase was evaporated to dryness at 60 °C under atmospheric pressure. Subsequently, the MTBE in the residue was completely evaporated. Under reduced pressure, toluene (458 g) was added and the temperature of the system was raised to 95 °C to dissolve all substances. It was cooled to 18-22 °C and filtered and the filter cake was washed with toluene. Finally, it was dried at 50-55 °C under vacuum (-0.095 MPa) to give 109.4 g of off-white solid product with ≥98% purity and 73.5% yield.
References
[1] Patent: CN107954861, 2018, A. Location in patent: Paragraph 0094; 0095
[2] Tetrahedron, 2015, vol. 71, # 2, p. 283 - 292
2-BROMO-5-IODOBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 | mina@chuanghaibio.com | China | 18126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
View Lastest Price from 2-BROMO-5-IODOBENZOIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-27 | 2-BROMO-5-IODOBENZOIC ACID
25252-00-0
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2021-08-12 | 2-BROMO-5-IODOBENZOIC ACID
25252-00-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-09 | 2-BROMO-5-IODOBENZOIC ACID
25252-00-0
|
$3.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- 2-BROMO-5-IODOBENZOIC ACID
25252-00-0
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-BROMO-5-IODOBENZOIC ACID
25252-00-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-BROMO-5-IODOBENZOIC ACID
25252-00-0
- $3.00
- 98%
- Career Henan Chemical Co
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