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(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone structure

CAS No.: 461432-22-4

Chemical Name:: (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone

Synonyms: Dapagliflozin iMpurity A;Dapagliflozin-15;Dapagliflozin Impurity 18;Dapagliflozin Bromomethanone;Dapagliflozin Intermediate I;5-broMo-2-chloro-4'-ethoxybenzophenone;(5-broMo-2-chlorophenyl)(4-ethoxyphenyl)-;5-bromo-2-chloro-4’-ethoxydiphenylmethanone;5-Bromo-2-ChIorophenyI 4-Ethoxypheny Methanone;(5-Bromo-2-chlorophenyl)(4-oxophenyl)methanone

CBNumber:: CB11509853

Molecular Formula:: C15H12BrClO2

Molecular Weight:: 339.61

MDL Number:: MFCD11044417

MOL File:: 461432-22-4.mol

MSDS File:: SDS

Last updated:2026-05-27 23:11:13

Product description	Number	Pack Size	Price
(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	435339	250mg	$305
(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	435339	1g	$389
(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	TRC-B680542-5G	5g	$177
(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	TRC-B680542-250MG	250mg	$70
(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	TRC-B680542-1G	1g	$83
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(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Properties

Boiling point	439.2±40.0 °C(Predicted)
Density	1.437
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Low-Melting Solid
color	Off-White to Pale Yellow
InChI	InChI=1S/C15H12BrClO2/c1-2-19-12-6-3-10(4-7-12)15(18)13-9-11(16)5-8-14(13)17/h3-9H,2H2,1H3
InChIKey	OEURLNJEQCLGPS-UHFFFAOYSA-N
SMILES	C(C1=CC(Br)=CC=C1Cl)(C1=CC=C(OCC)C=C1)=O
CAS DataBase Reference	461432-22-4

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P261-P305+P351+P338
REACH Registrations	Active

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	435339	(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	461432-22-4	250mg	$305	2026-06-03	Buy
Usbiological	435339	(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	461432-22-4	1g	$389	2026-06-03	Buy
TRC	TRC-B680542-5G	(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	461432-22-4	5g	$177	2026-06-03	Buy
TRC	TRC-B680542-250MG	(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	461432-22-4	250mg	$70	2026-06-03	Buy
TRC	TRC-B680542-1G	(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	461432-22-4	1g	$83	2026-06-03	Buy

Product number	Packaging	Price	Buy
435339	250mg	$305	Buy
435339	1g	$389	Buy
TRC-B680542-5G	5g	$177	Buy
TRC-B680542-250MG	250mg	$70	Buy
TRC-B680542-1G	1g	$83	Buy

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Chemical Properties,Uses,Production

Uses

(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone is an intermediate used in the improved synthesis of Dapagliflozin, a novel selective sodium-glucose co-transporter type II (SGLT2) inhibitor.

Synthesis

21900-52-7

103-73-1

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone

461432-22-4

Under the protection of nitrogen, 2.1 g of tert-butyldimethylchlorosilane prepared in step 1) was mixed with 5-bromo-2-chlorobenzoyl chloride in anhydrous dichloromethane and stirred for 30 min at 0 to 10 °C. Subsequently, 1.2 mol of phenethyl ether and 1.1 mol of ferric chloride were sequentially added to the reaction system, and the reaction temperature was maintained at 14.7 °C, and the reaction continued to be stirred for 5 hours. After completion of the reaction, the reaction mixture was quenched by pouring it into ice water, extracted with dichloromethane, the organic phase was washed with water, and 31 g of 5-bromo-2-chloro-4'-ethoxy benzophenone (intermediate of dagliflozin) was obtained after concentration in 91.4% yield and 99.49% purity.

References

[1] Patent: CN107200683, 2017, A. Location in patent: Paragraph 0029; 0035; 0039; 0043; 0047
[2] Patent: CN107417515, 2017, A. Location in patent: Paragraph 0030; 0032; 0034; 0036; 0038; 0040
[3] Patent: CN103739581, 2016, B. Location in patent: Paragraph 0228; 0229
[4] Patent: WO2012/25857, 2012, A1. Location in patent: Page/Page column 20
[5] Patent: CN106316803, 2017, A. Location in patent: Paragraph 0014

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone synthesis

Synthesis of (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone from 5-Bromo-2-chlorobenzoic acid and Phenetole

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Preparation Products And Raw materials

Raw materials

5-Bromo-2-chlorobenzoic acid Fluorobenzene 5-BROMO-2-CHLORO-BENZOYL CHLORIDE (5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone Ethanol

Phenetole Sodium ethoxide Ferric chloride Dichloromethane tert-Butyldimethylsilyl chloride

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Preparation Products

4-(5-broMo-2-chlorobenzyl)phenol 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Suppliers

Global( 399)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	294	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
Hebei Xinsheng New Material Technology Co., LTD.	+86-16632316109	xinshengkeji@xsmaterial.com	China	1085	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20120	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	+8618627948422	sale@hdimpurity.com	China	3681	58
Suzhou Nordica Biopharma CO.,LTD	+86-18136148818 +86-18567353071	3537297702@qq.com	China	299	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60

Supplier	Advantage
Anhui Dexinjia Biopharm Co., Ltd	58
Hangzhou ICH Biofarm Co., Ltd	58
Hebei Xinsheng New Material Technology Co., LTD.	58
Henan Fengda Chemical Co., Ltd	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
Suzhou Nordica Biopharma CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60

View Lastest Price from (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-22	(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 461432-22-4	$150.00-200.00	1kg	99%	5000kg per month	Anhui Dexinjia Biopharm Co., Ltd
2026-07-09	(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 461432-22-4	$5.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 461432-22-4		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
461432-22-4
$150.00-200.00
99%
Anhui Dexinjia Biopharm Co., Ltd

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
461432-22-4
$5.00
99%
Henan Fengda Chemical Co., Ltd

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
461432-22-4
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Spectrum

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone(461432-22-4)¹HNMR

461432-22-4((5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone)Related Search:

(5-broMo-2-chloro-phenyl)-(4-ethoxy-phenyl)-Methanone Dapagliflozin Dapagliflozin iMpurity BMS-639432 (2S,3R,4R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-5-((S)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol

(2R,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol Dapagliflozin Open Ring (1-Bromoethyl)benzene 2-Bromotoluene 4,4'-DDT

Rivaroxaban 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 5-bromo-2-chloro-4’-ethoxydiphenylmethane 4-BROMO-1-CHLORO-2-ETHYLBENZENE 3-BROMO-4''-METHOXYBENZOPHENONE

3-BROMO-4'-ETHOXYBENZOPHENONE (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 2-CHLORO-4'-ETHOXYBENZOPHENONE

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(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Methanone, (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)- (5-broMo-2-chlorophenyl)(4-ethoxyphenyl)- 5-broMo-2-chloro-4'-ethoxybenzophenone (5-BroMo-2-chlorophenyl)(4-ethoxypheny)Methanone Dapagliflozin Intermediate I Dapagliflozin Impurity 6Q: What is Dapagliflozin Impurity 6 Q: What is the CAS Number of Dapagliflozin Impurity 6 Q: What is the storage condition of Dapagliflozin Impurity 6 Q: What are the applications of Dapagliflozin Impurity 6 Dapagliflozin Impurity 18 Dapagliflozin-15 Dapagliflozin Bromomethanone (2-chloro 5-bromo phenyl)(4-ethoxy phenyl) methanone (5-bromo-2-chlorophyl)(4-ethoxyphenyl)methanone 5-Bromo-2-ChIorophenyI 4-Ethoxypheny Methanone (4-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 5-bromo-2-chloro-4’-ethoxydiphenylmethanone (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanoate (5-bromo-2-chlorophenyl) (4-ethoxyphen)methanone (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methano (5-Bromo-2-chlorophenyl)(4-oxophenyl)methanone (5-Bromo-2-chIoropheiylN4-ethoaxyphenylJmethanone Dapagliflozin iMpurity A 461432-22-4 140447-10-6 API intermediates API

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