1-Amino-4-methylpiperazine
- CAS No.
- 6928-85-4
- Chemical Name:
- 1-Amino-4-methylpiperazine
- Synonyms
- 4-methylpiperazin-1-amine;AMPRZ;1A4MP;1-Amino-4-Methyl;TIMTEC-BB SBB004299;AMINOMETHYLPIPERAZINE;LABOTEST-BB LT00005082;1-piperazinylmethanamine;1-METHYL-4-AMINOPIERAZINE;1-AMINO-4-METHYLPIERAZINE
- CBNumber:
- CB1177970
- Molecular Formula:
- C5H13N3
- Molecular Weight:
- 115.18
- MDL Number:
- MFCD00006154
- MOL File:
- 6928-85-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Amino-4-methylpiperazine 97% | 255688 | 25g | $70.9 |
| 1-Amino-4-methylpiperazine >98.0%(GC)(T) | A1192 | 25mL | $69 |
| 1-Amino-4-methylpiperazine >98.0%(GC)(T) | A1192 | 500mL | $1028 |
| 1-Amino-4-methylpiperazine (>90%) | TRC-A613435-25G | 25g | $68 |
| 1-Amino-4-methylpiperazine (>90%) | TRC-A613435-100G | 100g | $151 |
| More product size | |||
| Boiling point | 172-175 °C (lit.) |
|---|---|
| Density | 0.957 g/mL at 25 °C (lit.) |
| vapor pressure | 1.29hPa at 25℃ |
| refractive index | 1.4835-1.4855 |
| Flash point | 62 °C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | water: soluble |
| form | Viscous Solution |
| pka | 7+-.0.42(Predicted) |
| color | Clear |
| Water Solubility | miscible |
| Sensitive | Air & Light Sensitive |
| BRN | 103334 |
| InChI | 1S/C5H13N3/c1-7-2-4-8(6)5-3-7/h2-6H2,1H3 |
| InChIKey | RJWLLQWLBMJCFD-UHFFFAOYSA-N |
| SMILES | CN1CCN(N)CC1 |
| LogP | -1.61 at 25℃ |
| CAS DataBase Reference | 6928-85-4(CAS DataBase Reference) |
| FDA UNII | J5GBT1LFT2 |
| NIST Chemistry Reference | 1-Amino-4-methylpiperazine(6928-85-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| RIDADR | 2733 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335995 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
1-Amino-4-methylpiperazine price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 255688 | 1-Amino-4-methylpiperazine 97% | 6928-85-4 | 25g | $70.9 | 2026-04-30 | Buy |
| TCI Chemical | A1192 | 1-Amino-4-methylpiperazine >98.0%(GC)(T) | 6928-85-4 | 25mL | $69 | 2026-04-30 | Buy |
| TCI Chemical | A1192 | 1-Amino-4-methylpiperazine >98.0%(GC)(T) | 6928-85-4 | 500mL | $1028 | 2026-04-30 | Buy |
| TRC | TRC-A613435-25G | 1-Amino-4-methylpiperazine (>90%) | 6928-85-4 | 25g | $68 | 2026-06-03 | Buy |
| TRC | TRC-A613435-100G | 1-Amino-4-methylpiperazine (>90%) | 6928-85-4 | 100g | $151 | 2026-06-03 | Buy |
1-Amino-4-methylpiperazine Chemical Properties,Uses,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
1-Amino-4-methylpiperazine has been used:
in synthesis of pyrazolo-pyrazine, -pyridine derivatives and 2-[(4-methylpiperazin-1-yl)iminomethyl]phenol
as a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm)
synthesis of N-(4-Fluorobenzylidene)-4-methylpiperazin1-amine
synthesis of 4-Methyl-N-(3,4,5-trimethoxybenzylidene) piperazin-1-amine
synthesis of N-(3,4-Dichlorobenzylidene)-4- methylpiperazin-1-amine
synthesis of N-(4-(Diethylamino)benzylidene)-4- methylpiperazin-1-amine
synthesis of N-(2,5-Dimethoxybenzylidene)-4- methylpiperazin-1-amine
synthesis of 4-Methyl-N-((5-nitrofuran-2- yl)methylene)piperazin-1-amine
Preparation
1-Amino-4-methylpiperazine is obtained from piperazine hexahydrate through the steps of methylation, hydrolysis, nitrosation and reduction.
1-Amino-4-methylpiperazine is synthesized by chlorination of methyl(diethanol)amine (I) and subsequent cyclization of the di(chloroethyl)amine (II) obtained in aqueous hydrazine.
Application
1-Amino-4-methylpiperazine, a derivative of piperazine, is used widely as an intermediate in the synthesis of pharmaceutical agents. It is an important intermediate for Rifampicin. Rifampicin , known as rifampin, is an antibiotic used to treat a several kinds of bacterial infections such as tuberculosis, leprosy and Legionnare's disease.
Flammability and Explosibility
Not classified
1-Amino-4-methylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
View Lastest Price from 1-Amino-4-methylpiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 4-Methyl-1-piperazinamine
6928-85-4
|
$3.00-10.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 1-Amino-4-methylpiperazine
6928-85-4
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-15 | 1-Amino-4-methylpiperazine
6928-85-4
|
$1.50 | 1g | 99.0% Min | 100 Tons | Shaanxi Didu New Materials Co. Ltd |
-
- 4-Methyl-1-piperazinamine
6928-85-4
- $3.00-10.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1-Amino-4-methylpiperazine
6928-85-4
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-Amino-4-methylpiperazine
6928-85-4
- $1.50
- 99.0% Min
- Shaanxi Didu New Materials Co. Ltd
