2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE
- CAS No.
- 64874-38-0
- Chemical Name:
- 2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE
- Synonyms
- 6-BROMO-1,8-NAPHTHYRIDIN-2-AMINE;2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE;1,8-Naphthyridin-2-amine, 6-bromo-;6-Bromo-1,8-naphthyridin-2-amine, 2-Amino-6-bromo-1,8-diazanaphthalene
- CBNumber:
- CB12452774
- Molecular Formula:
- C8H6BrN3
- Molecular Weight:
- 224.06
- MDL Number:
- MFCD09909648
- MOL File:
- 64874-38-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Amino-6-bromo-1,8-naphthyridine 98% | OR41142 | 100mg | $25 |
| 2-Amino-6-bromo-1,8-naphthyridine 98% | OR41142 | 250mg | $59 |
| 2-Amino-6-bromo-1,8-naphthyridine 98% | OR41142 | 1g | $75 |
| 2-Amino-6-bromo-1,8-naphthyridine 98% | OR41142 | 5g | $258 |
| 2-Amino-6-bromo-1,8-naphthyridine | 072292 | 250.00mg | $52 |
| More product size | |||
| Melting point | 210-212 °C (sublm) |
|---|---|
| Boiling point | 357.2±37.0 °C(Predicted) |
| Density | 1.744±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | solid |
| pka | 4.15±0.30(Predicted) |
| Appearance | Light yellow to orange Solid |
| InChI | 1S/C8H6BrN3/c9-6-3-5-1-2-7(10)12-8(5)11-4-6/h1-4H,(H2,10,11,12) |
| InChIKey | PEDHUXRIIJIMDP-UHFFFAOYSA-N |
| SMILES | Nc1ccc2cc(Br)cnc2n1 |
| UNSPSC Code | 12352116 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 41 |
| Safety Statements | 26-39 |
| WGK Germany | WGK 3 |
| HS Code | 2902900000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 |
2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR41142 | 2-Amino-6-bromo-1,8-naphthyridine 98% | 64874-38-0 | 100mg | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR41142 | 2-Amino-6-bromo-1,8-naphthyridine 98% | 64874-38-0 | 250mg | $59 | 2026-06-04 | Buy |
| Apolloscientific | OR41142 | 2-Amino-6-bromo-1,8-naphthyridine 98% | 64874-38-0 | 1g | $75 | 2026-06-04 | Buy |
| Apolloscientific | OR41142 | 2-Amino-6-bromo-1,8-naphthyridine 98% | 64874-38-0 | 5g | $258 | 2026-06-04 | Buy |
| Matrix Scientific | 072292 | 2-Amino-6-bromo-1,8-naphthyridine | 64874-38-0 | 250.00mg | $52 | 2026-05-18 | Buy |
2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE Chemical Properties,Uses,Production
Uses
6-Bromo-1,8-naphthyridin-2-amine is used as a reactant in the preparation of substituted naphthyridines as H-PGDS inhibitors.
Synthesis
141-86-6
2065-75-0
64874-38-0
General procedure for the synthesis of 2-amino-6-bromo-1,8-naphthyridine from 2,6-diaminopyridine and 2-bromomalonaldehyde: 2,6-diaminopyridine (6.0 g, 55 mmol) and 2-bromo-1,3-malonaldehyde (8.0 g, 53 mmol) were dissolved in 85% orthophosphoric acid (160 mL) and heated and refluxed for 6 hours. Upon completion of the reaction, the reaction endpoint was confirmed by thin layer chromatography (TLC) monitoring. After cooling the reaction mixture to room temperature, it was neutralized with ammonia (NH4OH) solution to give a dark brown solid. After filtration and drying of this solid, it was dissolved in methanol (MeOH) with the aid of sonication. Purification by column chromatography afforded the light yellow solid product 2-amino-6-bromo-1,8-naphthyridine (3.85 g, 30.3% yield), which had an Rf value of 0.39 (unfolding reagent ratio CH2Cl2:MeOH = 10:1) and a melting point of 160-162°C (literature value 4: 210-212°C). The 1H NMR (500 MHz, DMSO-d6) data of the product were as follows: δ 7.82 (d, J = 2.6 Hz, 1H), 7.46 (d, J = 2.6 Hz, 1H), 7.04 (d, J = 8.8 Hz, 1H), 6.14 (s, 2H), 5.99 (d, J = 8.8 Hz, 1H).
References
[1] Heterocycles, 2015, vol. 91, # 5, p. 1001 - 1006
2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49962 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Hangzhou Milon Pharmatech Co.,Ltd. | +8618083715844 | sales02@milonpharm.com | China | 331 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
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