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ChemicalBook >> CAS DataBase List >>2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

CAS No.
132813-14-0
Chemical Name:
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
Synonyms
BlonserinImpurity14;Blonanserin Impurity 14;Blonanserin Intermediate;Blonanserin Impurity INT2;2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10...;2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[...;2-CHLORO-4-(4-FLUOROPHENYL)-5H,6H,7H,8H,9H,10H-CYCLOOCTA[B]PYRIDINE;2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctapyridine;2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine;Cycloocta[b]pyridine, 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-
CBNumber:
CB12510010
Molecular Formula:
C17H17ClFN
Molecular Weight:
289.77
MDL Number:
MFCD09955376
MOL File:
132813-14-0.mol
MSDS File:
SDS
Last updated:2026-05-27 23:19:18
Product description Number Pack Size Price
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 416683 500mg $382
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 416683 1g $566
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine TRC-C374775-5G 5g $1324
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 089900 100.00mg $41
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 089900 250.00mg $60
More product size

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine Properties

Melting point 137-140°C
Boiling point 414.7±45.0 °C(Predicted)
Density 1.175
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly, Heated)
pka 1.49±0.20(Predicted)
form Solid
color Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 416683 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 132813-14-0 500mg $382 2026-06-03 Buy
Usbiological 416683 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 132813-14-0 1g $566 2026-06-03 Buy
TRC TRC-C374775-5G 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 132813-14-0 5g $1324 2026-06-03 Buy
Matrix Scientific 089900 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 132813-14-0 100.00mg $41 2026-05-18 Buy
Matrix Scientific 089900 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 132813-14-0 250.00mg $60 2026-05-18 Buy
Product number Packaging Price Buy
416683 500mg $382 Buy
416683 1g $566 Buy
TRC-C374775-5G 5g $1324 Buy
089900 100.00mg $41 Buy
089900 250.00mg $60 Buy

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine Chemical Properties,Uses,Production

Uses

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine is an intermediate in the synthesis of Blonanserin (B595850), a 5-HT2 serotonin receptor and D2 dopamine receptor antagonist, used as an antipsychotic.

Synthesis

4-(4-Fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2(1H)-one

132812-72-7

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

132813-14-0

General procedure for the synthesis of 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine from 4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine as 4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine: 80.0 g of 4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b] Pyridin-2(1H)-one was dissolved in 520 mL of dimethylformamide and cooled to 5 °C. Under stirring, 36.84 g of phosphorus pentachloride was added in 10 portions. After addition, the temperature of the reaction system was raised to 15 °C and the reaction was continued for 3 hours. Upon completion of the reaction, 520 mL of purified water was added to the reaction mixture and stirred at 10 °C for 1 hour. The reaction solution was filtered using a Brinell funnel (Coors), the precipitated crystals were collected and the filter cake was washed with 300 mL of purified water. The resulting crystals were dried at 70 °C to afford 80.0 g of off-white 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine in 93.6% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 4, p. 1055 - 1059
[2] Patent: KR2015/117123, 2015, A. Location in patent: Paragraph 0046; 0047; 0048
[3] Patent: , 2016, . Location in patent: Paragraph 0026; 0027; 0028; 0029
[4] Asian Journal of Chemistry, 2014, vol. 26, # 18, p. 5928 - 5930
[5] Patent: JP2018/43989, 2018, A. Location in patent: Paragraph 0136-0138

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine Preparation Products And Raw materials

Global( 108)Suppliers
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Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
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GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49962 58

View Lastest Price from 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine pictures 2025-12-24 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine pictures 2020-02-26 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0
 1KG 99.0%+ 100 tons Shaanxi Dideu Medichem Co. Ltd
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine pictures 2020-02-26 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0
 100g 99%+ 10 tons Shaanxi Dideu Medichem Co. Ltd
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine Cycloocta[b]pyridine, 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro- 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10... Blonanserin Intermediate 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctapyridine Blonanserin Impurity 14 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[... BlonserinImpurity14 2-CHLORO-4-(4-FLUOROPHENYL)-5H,6H,7H,8H,9H,10H-CYCLOOCTA[B]PYRIDINE Blonanserin Impurity INT2 132813-14-0 C17H17ClFN
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