3-bromo-5-methoxyaniline
- CAS No.
- 16618-68-1
- Chemical Name:
- 3-bromo-5-methoxyaniline
- Synonyms
- 3-bromo-5-methoxyaniline;3-Bromo-5-methoxyaniline 98%;3-bromo-5-methoxybenzenamine;3-BroMo-5-Methoxy-phenylaMine;3-broMo-5-MethoxyaMinobenzene;3-Bromo-5-methyloxybenzenamine;BenzenaMine, 3-broMo-5-Methoxy-;3-Amino-5-bromoanisole, 5-Bromo-m-anisidine
- CBNumber:
- CB12518470
- Molecular Formula:
- C7H8BrNO
- Molecular Weight:
- 202.05
- MDL Number:
- MFCD11878497
- MOL File:
- 16618-68-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Bromo-5-methoxyaniline 98% | AS41797 | 1g | $20 |
| 3-Bromo-5-methoxyaniline 98% | AS41797 | 5g | $33 |
| 3-Bromo-5-methoxyaniline 97% | OR40401 | 1g | $21 |
| 3-Bromo-5-methoxyaniline 98% | AS41797 | 25g | $117 |
| 3-Bromo-5-methoxyaniline 97% | OR40401 | 5g | $32 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331 |
| Precautionary statements | P280-P309+P311 |
| HS Code | 2922290090 |
3-bromo-5-methoxyaniline price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS41797 | 3-Bromo-5-methoxyaniline 98% | 16618-68-1 | 1g | $20 | 2026-06-04 | Buy |
| Activate Scientific | AS41797 | 3-Bromo-5-methoxyaniline 98% | 16618-68-1 | 5g | $33 | 2026-06-04 | Buy |
| Apolloscientific | OR40401 | 3-Bromo-5-methoxyaniline 97% | 16618-68-1 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS41797 | 3-Bromo-5-methoxyaniline 98% | 16618-68-1 | 25g | $117 | 2026-06-04 | Buy |
| Apolloscientific | OR40401 | 3-Bromo-5-methoxyaniline 97% | 16618-68-1 | 5g | $32 | 2026-06-04 | Buy |
3-bromo-5-methoxyaniline Chemical Properties,Uses,Production
Synthesis
16618-67-0
16618-68-1
General procedure for the synthesis of 3-bromo-5-methoxyaniline from 3-bromo-5-nitroanisole: 1. 30.0 g of 3,5-dinitrobenzene (0.18 mol) was dissolved in 180 mL of concentrated sulfuric acid and heated to 80 °C, maintaining the temperature between 80-90 °C. 44.5 g of N-bromosuccinimide (NBS, 0.25 mol) was added to the above solution in 9 batches and the reaction lasted for 30 min. After cooling, the reaction mixture was poured into 600 mL of ice water and a white precipitate was separated, which was filtered, washed and dried to give 41.3 g of white solid 3,5-dinitrobromobenzene in 93.7% yield. 2. Preparation of sodium solution in methanol: 1 g of sodium (43.4 mmol) was dissolved in methanol. Add 8.7 g of 3,5-dinitrobromobenzene (35.2 mmol) to the above sodium methanol solution, and reflux the reaction at 45°C for 2 hours. After cooling to room temperature, it was treated with 50 mL of 1N hydrochloric acid solution and then extracted with dichloromethane. The organic phases were combined, washed 3 times with saturated brine, dried over anhydrous magnesium sulfate, filtered and the solvent evaporated. The crude product was separated by column chromatography (petroleum ether:dichloromethane=5:1) to give 4.6g of 3-methoxy-5-nitrobromobenzene as a white powdery solid in 56.3% yield. 3. 2.32 g of 3-methoxy-5-nitrobromobenzene (10 mmol) was dissolved in 25 mL of methanol, 400 mg of Pd/C catalyst and 10 mL of acetone solution were added, and the reaction was carried out by passing hydrogen for 3 hours at room temperature. After completion of the reaction, the Pd/C was removed by filtration and the solvent was evaporated. The crude product was separated by column chromatography (petroleum ether:ethyl acetate=4:1) to give 1.95 g of 3-bromo-5-methoxyaniline as a light yellow solid in 96.5% yield.
References
[1] Patent: CN103497211, 2016, B. Location in patent: Paragraph 0074; 0075
[2] Patent: US2007/123527, 2007, A1. Location in patent: Page/Page column 79
[3] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0788
[4] Organic Letters, 2016, vol. 18, # 11, p. 2774 - 2776
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4889 - 4905
3-bromo-5-methoxyaniline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
| Changzhou Mascot Import & Export Co., Ltd | +86-0519-85010339 +86-13584504415 | info@mascot-ie.com | China | 435 | 58 |
View Lastest Price from 3-bromo-5-methoxyaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 3-bromo-5-methoxyaniline
16618-68-1
|
1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-09-03 | 3-bromo-5-methoxyaniline
16618-68-1
|
$7.00 | 1KG | 98% | Career Henan Chemical Co |
-
- 3-bromo-5-methoxyaniline
16618-68-1
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-bromo-5-methoxyaniline
16618-68-1
- $7.00
- 98%
- Career Henan Chemical Co
