ChemicalBook >> CAS DataBase List >>1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester structure

CAS No.: 1403474-70-3

Chemical Name:: 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester

Synonyms: Azilsartan Ethyl Ester Impurity;Azilsartan-22;Ethyl Azilsartan;Azilsartan impurity V;Azilsartan ethyl ester;ethyl ester of azilsartan;Azilsartan Acid Ethyl Ester;Azilsartan Kamedoxomil Impurity;methyl 2-(bis(tert-butoxycarbonyl)amino)-3-nitrobenzoate;1H-Benzimidazole-7-carboxylicacid,1-[[2'-(2,5-dihydro-5-oxo-...

CBNumber:: CB12645154

Molecular Formula:: C27H24N4O5

Molecular Weight:: 484.5

MDL Number:: MFCD28404679

MOL File:: 1403474-70-3.mol

MSDS File:: SDS

Last updated:2026-05-27 23:18:11

Product description	Number	Pack Size	Price
Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	448910	100mg	$382
Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	448910	250mg	$566
Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	DGC47470	25mg	$900
Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	DGC47470	250mg	$900
Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	DGC47470	100mg	$900
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1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester Properties

Melting point	171-175°C
Density	1.34±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	6.99±0.20(Predicted)
form	Solid
color	White to Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	448910	Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	1403474-70-3	100mg	$382	2026-06-03	Buy
Usbiological	448910	Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	1403474-70-3	250mg	$566	2026-06-03	Buy
Biosynth	DGC47470	Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	1403474-70-3	25mg	$900	2026-06-04	Buy
Biosynth	DGC47470	Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	1403474-70-3	250mg	$900	2026-06-04	Buy
Biosynth	DGC47470	Ethyl 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate	1403474-70-3	100mg	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
448910	100mg	$382	Buy
448910	250mg	$566	Buy
DGC47470	25mg	$900	Buy
DGC47470	250mg	$900	Buy
DGC47470	100mg	$900	Buy

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester Chemical Properties,Uses,Production

Uses

Ethyl 2-Ethoxy-1-((2''-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1''-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate is an impurity of Azilsartan (A926900), which is an analgesic and anti-inflammatory drug containing angiotensin II antagonists.

Synthesis

(Z)-Ethyl-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl) biphenyl-4-yl) Methyl)-3H-benzo[d] iMidazole-4-carboxylate

1397836-41-7

105-58-8

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester

1403474-70-3

The synthesis of 1-[[2'-(2'-(N'-hydroxyformamidinyl)-[1,1'-biphenyl]-4-yl]methyl]-1H-benzo[d]imidazole-7-carboxylic acid ethyl ester and diethyl carbonate was carried out using ethyl 2-ethoxime (II) and diethyl carbonate as the raw materials for the synthesis of 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxime (II) The general procedure for ethyl -7-carboxylate was as follows: ethoxime (II) (390 g, 851 mmol) was suspended in 3600 mL of diethyl carbonate. The suspension was heated to 65°C. An ethanolic solution of sodium ethoxide (21%, 400 mL, 1072 mmol) was added dropwise to the reaction mixture over 30 minutes at 65°C. After the dropwise addition, the reaction mixture was continued to be stirred at 65 °C for 30 min. Subsequently, the reaction mixture was cooled to 60 °C and water (1350 mL) was added. The resulting emulsion was stirred for at least 15 minutes. After separation of the layers, the organic phase was extracted with water (1350 mL). The aqueous phase extracts were combined, diluted with ethanol (1350 mL) and the temperature was adjusted to 40 °C. Acetic acid (111 mL, 1940 mmol) was added dropwise to the solution over 40 minutes at 40°C. The regenerated suspension was stirred at 40 °C for 30 min and then cooled to 20 °C. The solid product was separated by suction filtration and washed with water (2 x 450 mL). Finally, the product was dried in a vacuum desiccator at 45 °C to give 397 g of azilsartan ethyl ester (III) in 86% yield of the theoretical amount and 95.8% HPLC purity.

References

[1] Patent: WO2016/58563, 2016, A1. Location in patent: Page/Page column 7
[2] Patent: WO2012/139536, 2012, A1. Location in patent: Page/Page column 21

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester Preparation Products And Raw materials

Raw materials

2-Ethoxy-1-[[2'-[[[(ethoxycarbonyl)oxy]amino]iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid ethyl ester PHOSGENE (Z)-Ethyl-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl) biphenyl-4-yl) Methyl)-3H-benzo[d] iMidazole-4-carboxylate 1,1'-Carbonyldiimidazole Diethyl carbonate

Water Sodium ethoxide Ethanol

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Preparation Products

Azilsartan

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester Suppliers

Global( 100)Suppliers

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ShenZhen H&D Pharmaceutical Technology Co., LTD	+86-18627948422	sale@hdimpurity.com	China	3681	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-15225627621 +86-13213167925	jiuyitime@fdachem.com	China	16511	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29792	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29093	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15079	58
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Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3148	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +86-18949823763	sales@tnjchem.com	China	25356	58
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Supplier	Advantage
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Standardpharm Co. Ltd.	58
career henan chemical co	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
BOC Sciences	58
Hangzhou Huarong Pharm Co., Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58

View Lastest Price from 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-02	1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester 1403474-70-3	$2.00-5.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-03-12	Azilsartan impurity V		10mg	98%	500mg	ShenZhen H&D Pharmaceutical Technology Co., LTD
2026-03-12	Azilsartan impurity Y 1403474-70-3		10mg	98%	500mg	ShenZhen H&D Pharmaceutical Technology Co., LTD

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester
1403474-70-3
$2.00-5.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Azilsartan impurity V
98%
ShenZhen H&D Pharmaceutical Technology Co., LTD

Azilsartan impurity Y
1403474-70-3
98%
ShenZhen H&D Pharmaceutical Technology Co., LTD

1403474-70-3(1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester)Related Search:

Azilsartan ethyl2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester Azilsartan Impurity 1-[(2'-carbaMoylbiphenyl-4-yl) Methyl]-2-ethoxybenziMidazole-7-carboxylic acid

(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate 1-((2'-cyanobiphenyl-4-yl)Methyl)-2-ethoxy-1H-benziMidazole-7-carboxylic acid Azilsartan Impurity Olodaterol Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate

O-Desethyl Azilsartan Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate Azilsartan Impurity (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid Azilsartan Impurity

(Z)-Methyl 3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate 1-[[2'-(AMinoiMinoMethyl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-1H-benziMidazole-7-carboxylic Acid Azilsartan iMpurity I

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1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid ethyl ester ethyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate Ethyl 2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate ethyl ester of azilsartan Azilsartan impurity V Azilsartan impurity 23/Azilsartan Ethyl Impurity/Ethyl 2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate Azilsartan-22 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl esterChemicalBook Azilsartan Kamedoxomil Impurity 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4- Azilsartan Acid Ethyl Ester ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid 1H-Benzimidazole-7-carboxylicacid,1-[[2'-(2,5-dihydro-5-oxo-... Ethyl 2-Ethoxy-1-((2-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1-biphenyl]-4-yl)methyl)-1H-benzo methyl 2-(bis(tert-butoxycarbonyl)amino)-3-nitrobenzoate Ethyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate Azilsartan ethyl ester Ethyl Azilsartan Azilsartan Ethyl Impurity ethyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl) -[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7- carboxylate 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid ethyl ester 1- [(2 '- [(ethoxycarbonyl) oxy] amidino) [1,1-biphenyl] -4-yl) methyl] -2-ethoxy-1H-benzimidazole-7-carboxylic acid ethyl ester Azilsartan Ethyl Ester Impurity 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl]Methyl]-2-Ethoxy-1H-benzo-Imidazole-7-carboxylic acid Ethyl ester (Azilsartan intermediate) 1403474-70-3

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