LBW242
- CAS No.
- 867324-12-7
- Chemical Name:
- LBW242
- Synonyms
- LBW242;LBW242,LBW-242;Propanamide, N-[(1S)-1-cyclohexyl-2-[(3aR,7aS)-octahydro-6-(2-phenylethyl)-1H-pyrrolo[2,3-c]pyridin-1-yl]-2-oxoethyl]-2-(methylamino)-, (2S)-;(2S)-N-[(1S)-2-[(3aR,7aS)-6-(2-phenylethyl)-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-1-yl]-1-cyclohexyl-2-oxoethyl]-2-(methylamino)propanamide
- CBNumber:
- CB12655410
- Molecular Formula:
- C27H42N4O2
- Molecular Weight:
- 454.65
- MDL Number:
- MFCD23160050
- MOL File:
- 867324-12-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 645.2±55.0 °C(Predicted) |
|---|---|
| Density | 1.098±0.06 g/cm3(Predicted) |
| pka | 14.22±0.46(Predicted) |
| FDA UNII | NG5DD6UA5D |
LBW242 Chemical Properties,Uses,Production
Uses
LBW242, a 3-mer and Smac mimetic, is a potent and orally active proapoptotic IAP inhibitor. LBW242 shows effects on mutant FLT3-expressing cells. LBW242 has activity against multiple myeloma, and potentiates TRAIL- and anticancer agent-mediated cell death of ovarian cancer cells[1][2].
in vivo
LBW242 (50 mg/kg; p.o.; daily for 10 days) reduces tumor burden[1].
| Animal Model: | NCR nude mice were inoculated with FLT3-ITD-Ba/F3 cells[1] |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage; daily for 10 days |
| Result: | Effective in reducing tumor burden. |
References
[1] Weisberg E, et al. Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells. Mol Cancer Ther. 2007 Jul;6(7):1951-61. DOI:10.1158/1535-7163.MCT-06-0810
[2] Petrucci E, et al. A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells. PLoS One. 2012;7(4):e35073. DOI:10.1371/journal.pone.0035073
LBW242 Preparation Products And Raw materials
Raw materials
Preparation Products
LBW242 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 588 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29867 | 58 |
